Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody

Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure

(2016) Chi-Kin Chow et al.   MOLECULAR PHARMACEUTICS

Antibody humanization by structure-based computational protein design

(2015) Yoonjoo Choi et al.   mAbs

A Web Resource for Standardized Benchmark Datasets, Metrics, and Rosetta Protocols for Macromolecular Modeling and Design

(2015) Shane Ó Conchúir et al.   PLoS One

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies

(2015) Sue Townsend et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AB-Bind: Antibody binding mutational database for computational affinity predictions

(2015) Sarah Sirin et al.   PROTEIN SCIENCE

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

(2014) Jasmin F. Sydow et al.   PLoS One

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoclonal antibody humanness score and its applications

(2013) Sean H Gao et al.   BMC BIOTECHNOLOGY

T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation

(2013) Vibha Jawa et al.   CLINICAL IMMUNOLOGY

Humanization of Antibodies Using Heavy Chain Complementarity-determining Region 3 Grafting Coupled within VitroSomatic Hypermutation

(2013) Peter M. Bowers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational Prediction of Protein Hot Spot Residues

(2012) John Kenneth Morrow et al.   CURRENT PHARMACEUTICAL DESIGN

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

(2012) Sharon A. Townson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myostatin as a therapeutic target in Amyotrophic Lateral Sclerosis

(2012) Frank S. Walsh et al.   NEUROCHEMISTRY INTERNATIONAL

Structure of Myostatin·Follistatin-like 3

(2011) Jennifer N. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies

(2011) Amy C. King et al.   PROTEIN SCIENCE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

BMP-7 as antagonist of organ fibrosis

(2010) Ralf Weiskirchen   Frontiers in Bioscience-Landmark

Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB

(2010) Dianne Sako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predictive tools for stabilization of therapeutic proteins

(2010) Vladimir Voynov et al.   mAbs

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

Reducing risk, improving outcomes: Bioengineering less immunogenic protein therapeutics

(2009) Anne S. De Groot et al.   CLINICAL IMMUNOLOGY

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

(2009) Jennifer N Cash et al.   EMBO JOURNAL

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5–type I receptor specificity

(2009) Alexander Kotzsch et al.   EMBO JOURNAL

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

(2009) Paul D. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework

(2009) Markus Kügler et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains

(2009) Annemarie Honegger et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

(2008) Kathryn R. Wagner et al.   ANNALS OF NEUROLOGY

Role of transforming growth factor-β superfamily signaling pathways in human disease

(2008) Kelly J. Gordon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Myostatin as a therapeutic target for musculoskeletal disease

(2008) L. Bradley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fully human antibodies from transgenic mouse and phage display platforms

(2008) Nils Lonberg   CURRENT OPINION IN IMMUNOLOGY

An Engineered Human Antibody Fab Fragment Specific for Pseudomonas aeruginosa PcrV Antigen Has Potent Antibacterial Activity

(2008) M. Baer et al.   INFECTION AND IMMUNITY