Molecular mechanism of polymer-assisting supersaturation of poorly water-soluble loratadine based on experimental observations and molecular dynamic simulations
出版年份 2017 全文链接
标题
Molecular mechanism of polymer-assisting supersaturation of poorly water-soluble loratadine based on experimental observations and molecular dynamic simulations
作者
关键词
Supersaturation, Solvent shift method, pH transfer test, Molecular docking, Molecular dynamics simulation
出版物
Drug Delivery and Translational Research
Volume 7, Issue 5, Pages 738-749
出版商
Springer Nature
发表日期
2017-07-05
DOI
10.1007/s13346-017-0401-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Crystallizing Micronized Particles of a Poorly Water-Soluble Active Pharmaceutical Ingredient: Nucleation Enhancement by Polymeric Additives
- (2016) Sendhil K. Poornachary et al. CRYSTAL GROWTH & DESIGN
- Supersaturation Potential of Salt, Co-Crystal, and Amorphous Forms of a Model Weak Base
- (2016) Luis Almeida e Sousa et al. CRYSTAL GROWTH & DESIGN
- Solvent-shift strategy to identify suitable polymers to inhibit humidity-induced solid-state crystallization of lacidipine amorphous solid dispersions
- (2016) Mengchi Sun et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Probing the role of chemical enhancers in facilitating drug release from patches: Mechanistic insights based on FT-IR spectroscopy, molecular modeling and thermal analysis
- (2016) Wenting Song et al. JOURNAL OF CONTROLLED RELEASE
- A silica-supported solid dispersion of bifendate using supercritical carbon dioxide method with enhanced dissolution rate and oral bioavailability
- (2015) Cuifang Cai et al. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
- Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers
- (2015) Dajun D. Sun et al. JOURNAL OF CONTROLLED RELEASE
- Drug–Polymer–Water Interaction and Its Implication for the Dissolution Performance of Amorphous Solid Dispersions
- (2015) Yuejie Chen et al. MOLECULAR PHARMACEUTICS
- Computer-Assisted Drug Formulation Design: Novel Approach in Drug Delivery
- (2015) Abdelkader A. Metwally et al. MOLECULAR PHARMACEUTICS
- Prediction of oral absorption of cinnarizine – A highly supersaturating poorly soluble weak base with borderline permeability
- (2014) Mark Berlin et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Dissolution evaluationin vitroand bioavailabilityin vivoof self-microemulsifying drug delivery systems for pH-sensitive drug loratadine
- (2014) Haiyan Li et al. JOURNAL OF MICROENCAPSULATION
- Excipient-Assisted Vinpocetine Nanoparticles: Experiments and Molecular Dynamic Simulations
- (2014) Cai-Xia Li et al. MOLECULAR PHARMACEUTICS
- Impact of Polymers on the Crystallization and Phase Transition Kinetics of Amorphous Nifedipine during Dissolution in Aqueous Media
- (2014) Shweta A. Raina et al. MOLECULAR PHARMACEUTICS
- Assessing the Efficiency of Polymeric Excipients by Atomistic Molecular Dynamics Simulations
- (2014) Prateek K. Jha et al. MOLECULAR PHARMACEUTICS
- Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald
- (2013) Romelia Salomon-Ferrer et al. Journal of Chemical Theory and Computation
- Studies of Bicalutamide–Excipients Interaction by Combination of Molecular Docking and Molecular Dynamics Simulation
- (2013) Caixia Li et al. MOLECULAR PHARMACEUTICS
- Investigating the molecular structures of solid dispersions by the simulated annealing method
- (2012) Defang Ouyang CHEMICAL PHYSICS LETTERS
- Effect of Additives on Crystal Growth and Nucleation of Amorphous Flutamide
- (2012) Niraj S. Trasi et al. CRYSTAL GROWTH & DESIGN
- Preparation and characterization of fusion processed solid dispersions containing a viscous thermally labile polymeric carrier
- (2012) Justin R. Hughey et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Solvent shift method for anti-precipitant screening of poorly soluble drugs using biorelevant medium and dimethyl sulfoxide
- (2011) Taro Yamashita et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Influence of relative humidity on the interaction between different aryl propionic acid derivatives and poly(vinylpyrrolydone) K30: Evaluation of the effect on drug bioavailability
- (2010) Ledjan Malaj et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- PACKMOL: A package for building initial configurations for molecular dynamics simulations
- (2009) L. Martínez et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Acid–base equilibria and solubility of loratadine and desloratadine in water and micellar media
- (2008) Gordana Popović et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started