Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis

(2016) Yulia Pustovalova et al.   BIOCHEMISTRY

The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling

(2016) Chenghao Peng et al.   CANCER RESEARCH

The Functions of Serine 687 Phosphorylation of Human DNA Polymerase η in UV Damage Tolerance

(2016) Xiaoxia Dai et al.   MOLECULAR & CELLULAR PROTEOMICS

miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair

(2016) J. R. Czochor et al.   MOLECULAR CANCER RESEARCH

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κ

(2016) Vikash Jha et al.   NUCLEIC ACIDS RESEARCH

DNA Polymerases Divide the Labor of Genome Replication

(2016) Scott A. Lujan et al.   TRENDS IN CELL BIOLOGY

miR-20b downregulates polymerases κ and θ in XP-V tumor cells

(2016) JIA GUO et al.   Oncology Letters

Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA

(2016) Emmanuelle Despras et al.   Nature Communications

Starvation Promotes REV1 SUMOylation and p53-Dependent Sensitization of Melanoma and Breast Cancer Cells

(2015) H. S. Shim et al.   CANCER RESEARCH

Cadmium treatment suppresses DNA polymerase δ catalytic subunit gene expression by acting on the p53 and Sp1 regulatory axis

(2015) Giulia Antoniali et al.   DNA REPAIR

Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells

(2015) Sara Bursomanno et al.   DNA REPAIR

Sp1 and the ‘hallmarks of cancer’

(2015) Kate Beishline et al.   FEBS Journal

FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

(2015) Yeran Yang et al.   NUCLEIC ACIDS RESEARCH

FF483–484 motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance

(2015) Nadège Baldeck et al.   NUCLEIC ACIDS RESEARCH

Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases

(2015) Yuji Masuda et al.   NUCLEIC ACIDS RESEARCH

A novel role for non-ubiquitinated FANCD2 in response to hydroxyurea-induced DNA damage

(2015) X Chen et al.   ONCOGENE

Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells

(2015) Amit Kumar Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase η is regulated by poly(rC)-binding protein 1 via mRNA stability

(2014) Cong Ren et al.   BIOCHEMICAL JOURNAL

Recent Insight into the Kinetic Mechanisms and Conformational Dynamics of Y-Family DNA Polymerases

(2014) Brian A. Maxwell et al.   BIOCHEMISTRY

An Overview of Y-Family DNA Polymerases and a Case Study of Human DNA Polymerase η

(2014) Wei Yang   BIOCHEMISTRY

Expression of the p12 subunit of human DNA polymerase δ (Pol δ), CDK inhibitor p21WAF1, Cdt1, cyclin A, PCNA and Ki-67 in relation to DNA replication in individual cells

(2014) Hong Zhao et al.   CELL CYCLE

TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase  

(2014) H. A. Wallace et al.   DEVELOPMENT

Uncovering global SUMOylation signaling networks in a site-specific manner

(2014) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability

(2014) J Qian et al.   ONCOGENE

Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct

(2014) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Pol   purified with accessory subunits is active in translesion DNA synthesis and complements Pol   in cisplatin bypass

(2014) Y.-S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast Cancer Proteins PALB2 and BRCA2 Stimulate Polymerase η in Recombination-Associated DNA Synthesis at Blocked Replication Forks

(2014) Rémi Buisson et al.   Cell Reports

The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression

(2013) Marietta Y.W.T. Lee et al.   CELL CYCLE

Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage

(2013) Dechen Fu et al.   CELL CYCLE

Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ

(2013) Szu Hua Sharon Lin et al.   DNA REPAIR

Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans

(2013) Marek Sebesta et al.   DNA REPAIR

Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks

(2013) Xiuli Zhang et al.   DNA REPAIR

DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation

(2013) Rémy Bétous et al.   EMBO JOURNAL

A Novel Function of CRL4Cdt2

(2013) Sufang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

The Human Specialized DNA Polymerases and Non-B DNA: Vital Relationships to Preserve Genome Integrity

(2013) Anne-Sophie Boyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Reconstitution of recombination-associated DNA synthesis with human proteins

(2013) Jessica L. Sneeden et al.   NUCLEIC ACIDS RESEARCH

UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

(2013) S. F. Mansilla et al.   NUCLEIC ACIDS RESEARCH

Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation

(2013) Lingna Lv et al.   NUCLEIC ACIDS RESEARCH

A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks

(2013) Michael Durando et al.   NUCLEIC ACIDS RESEARCH

Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells

(2013) Audesh Bhat et al.   NUCLEIC ACIDS RESEARCH

FANC Pathway Promotes UV-Induced Stalled Replication Forks Recovery by Acting Both Upstream and Downstream Polη and Rev1

(2013) Emilie Renaud et al.   PLoS One

Overexpressed DNA Polymerase Iota Regulated by JNK/c-Jun Contributes to Hypermutagenesis in Bladder Cancer

(2013) Fang Yuan et al.   PLoS One

BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade

(2013) F. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel POLH mutation causes XP-V disease and XP-V tumor proneness may involve imbalance of numerous DNA polymerases

(2013) JIA GUO et al.   Oncology Letters

MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition

(2012) Yemin Wang et al.   CANCER RESEARCH

Overexpression of DNApolymerase iota(Polι) in esophageal squamous cell carcinoma

(2012) Jundong Zhou et al.   CANCER SCIENCE

Spartan/C1orf124 is important to prevent UV-induced mutagenesis

(2012) Yuka Machida et al.   CELL CYCLE

Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage

(2012) Jennifer Chea et al.   CELL CYCLE

Regulation of human DNA polymerase delta in the cellular responses to DNA damage

(2012) Marietta Y.W.T. Lee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ

(2012) Yulia Pustovalova et al.   FEBS LETTERS

Segregation of Replicative DNA Polymerases during S Phase

(2012) Markku Vaara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Arginine Methyltransferase 7 Regulates Cellular Response to DNA Damage by Methylating Promoter Histones H2A and H4 of the Polymerase δ Catalytic Subunit Gene,POLD1

(2012) Vrajesh Karkhanis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interferon Regulatory Factor 1 Transactivates Expression of Human DNA Polymerase η in Response to CarcinogenN-Methyl-N′-nitro-N-nitrosoguanidine

(2012) Hongyan Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ

(2012) Jessica Wojtaszek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase δ for Degradation in Response to DNA Damage

(2012) Sufang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proliferating Cell Nuclear Antigen (PCNA)-binding Protein C1orf124 Is a Regulator of Translesion Synthesis

(2012) Gargi Ghosal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ

(2012) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication

(2012) Erin Walsh et al.   JOURNAL OF MOLECULAR BIOLOGY

Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response

(2012) Richard C. Centore et al.   MOLECULAR CELL

Noncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells

(2012) Javier Peña-Diaz et al.   MOLECULAR CELL

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

(2012) Emily J Davis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of Rev1 by the Fanconi anemia core complex

(2012) Hyungjin Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of error-prone translesion synthesis by Spartan/C1orf124

(2012) Myoung Shin Kim et al.   NUCLEIC ACIDS RESEARCH

Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance

(2012) Szilvia Juhasz et al.   NUCLEIC ACIDS RESEARCH

Evidence for a Rad18-Independent Frameshift Mutagenesis Pathway in Human Cell-Free Extracts

(2012) Régine Janel-Bintz et al.   PLoS One

Characterization of Human DNA Polymerase Delta and Its Subassemblies Reconstituted by Expression in the Multibac System

(2012) Yajing Zhou et al.   PLoS One

Structural basis of human DNA polymerase  -mediated chemoresistance to cisplatin

(2012) Y. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Broad Requirement for TLS Polymerases η and κ, and Interacting Sumoylation and Nuclear Pore Proteins, in Lesion Bypass during C. elegans Embryogenesis

(2012) Sophie F. Roerink et al.   PLoS Genetics

Phosphorylation of the p68 Subunit of Pol δ Acts as a Molecular Switch To Regulate Its Interaction with PCNA

(2011) Amal A. Rahmeh et al.   BIOCHEMISTRY

CRL4Cdt2

(2011) Tarek Abbas et al.   CELL CYCLE

DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation

(2011) Yong-Sam Jung et al.   DNA REPAIR

Characterization of human DNA polymerase κ promoter in response to benzo[a]pyrene diol epoxide

(2011) Huifang Zhu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Studies on Human DNA Polymerase ϵ and GINS Complex and Their Role in DNA Replication

(2011) Vladimir P. Bermudez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

(2011) Thomas Göhler et al.   JOURNAL OF CELL BIOLOGY

Molecular Chaperone Hsp90 Regulates REV1-Mediated Mutagenesis

(2011) F. Mayca Pozo et al.   MOLECULAR AND CELLULAR BIOLOGY

Pirh2 E3 Ubiquitin Ligase Monoubiquitinates DNA Polymerase Eta To Suppress Translesion DNA Synthesis

(2011) Y.-S. Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

(2011) Noam Diamant et al.   NUCLEIC ACIDS RESEARCH

Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

(2011) Suzanne E. Hile et al.   NUCLEIC ACIDS RESEARCH

The role of mRNA decay in p53-induced gene expression

(2011) B. D. Melanson et al.   RNA

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

(2011) Ayal Hendel et al.   PLoS Genetics

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

(2011) A. P. Jason de Koning et al.   PLoS Genetics

Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Polη

(2010) Agnès Tissier et al.   DNA REPAIR

Continued primer synthesis at stalled replication forks contributes to checkpoint activation

(2010) Christopher Van et al.   JOURNAL OF CELL BIOLOGY

The Molecular Chaperone Hsp90 Regulates Accumulation of DNA Polymerase η at Replication Stalling Sites in UV-Irradiated Cells

(2010) Takayuki Sekimoto et al.   MOLECULAR CELL

Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination

(2010) Marzena Bienko et al.   MOLECULAR CELL

Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

(2010) Tomoo Ogi et al.   MOLECULAR CELL

Structure and mechanism of human DNA polymerase η

(2010) Christian Biertümpfel et al.   NATURE

Interaction with DNA polymerase η is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells

(2009) Jun-ichi Akagi et al.   DNA REPAIR

Response of human DNA polymerase ι promoter to N-methyl-N′-nitro-N-nitrosoguanidine

(2009) Huifang Zhu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

(2009) Shan Yan et al.   JOURNAL OF CELL BIOLOGY

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Human DNA Polymerase   Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

(2009) L. Rey et al.   MOLECULAR AND CELLULAR BIOLOGY

Pirh2 E3 Ubiquitin Ligase Targets DNA Polymerase Eta for 20S Proteasomal Degradation

(2009) Y.-S. Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells

(2009) Rémy Bétous et al.   MOLECULAR CARCINOGENESIS

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

(2009) Sandeep N. Shah et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of the C subunit (p66) of human DNA polymerase δ

(2008) Laure Lemmens et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Phosphatase-1 Is Targeted to DNA Polymerase δ via an Interaction with the p68 Subunit†

(2008) Yan Gao et al.   BIOCHEMISTRY

Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts

(2008) J. Nicole Kosarek et al.   DNA REPAIR

The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly

(2008) Kanchan D. Mirchandani et al.   DNA REPAIR

Effect of Proliferating Cell Nuclear Antigen Ubiquitination and Chromatin Structure on the Dynamic Properties of the Y-family DNA Polymerases

(2008) Simone Sabbioneda et al.   MOLECULAR BIOLOGY OF THE CELL

Regulated Proteolysis of DNA Polymerase η during the DNA-Damage Response in C. elegans

(2008) Seung-Hwan Kim et al.   MOLECULAR CELL

Human DNA polymerase   activity and translocation is regulated by phosphorylation

(2008) Y.-w. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA