The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase δ

(2013) Szu Hua Sharon Lin et al.   DNA REPAIR

Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans

(2013) Marek Sebesta et al.   DNA REPAIR

Degradation of p12 Subunit by CRL4Cdt2E3 Ligase Inhibits Fork Progression after DNA Damage

(2013) Kenta Terai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of PCNA–protein interactions for genome stability

(2013) Niels Mailand et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reconstitution of recombination-associated DNA synthesis with human proteins

(2013) Jessica L. Sneeden et al.   NUCLEIC ACIDS RESEARCH

DNA Damage Response: Three Levels of DNA Repair Regulation

(2013) B. M. Sirbu et al.   Cold Spring Harbor Perspectives in Biology

Okazaki Fragment Metabolism

(2013) L. Balakrishnan et al.   Cold Spring Harbor Perspectives in Biology

Structure of monoubiquitinated PCNA

(2012) Zhongtao Zhang et al.   CELL CYCLE

Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage

(2012) Jennifer Chea et al.   CELL CYCLE

p21WAF1 and tumourigenesis

(2012) Noel A. Warfel et al.   CURRENT OPINION IN ONCOLOGY

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation

(2012) Thomas R Beattie et al.   EMBO JOURNAL

DNA polymerase kappa microsatellite synthesis: Two distinct mechanisms of slippage-mediated errors

(2012) Beverly A. Baptiste et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA polymerase delta in dna replication and genome maintenance

(2012) Marc J. Prindle et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Regulation of human DNA polymerase delta in the cellular responses to DNA damage

(2012) Marietta Y.W.T. Lee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Segregation of Replicative DNA Polymerases during S Phase

(2012) Markku Vaara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase δ for Degradation in Response to DNA Damage

(2012) Sufang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Replicative DNA Polymerase Delta Pausing and a Potential Role for DNA Polymerase Kappa in Common Fragile Site Replication

(2012) Erin Walsh et al.   JOURNAL OF MOLECULAR BIOLOGY

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of Human DNA Polymerase Delta and Its Subassemblies Reconstituted by Expression in the Multibac System

(2012) Yajing Zhou et al.   PLoS One

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

Inhibition of NEDD8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover

(2011) M. A. Milhollen et al.   CANCER RESEARCH

Ubiquitination of PCNA and Its Essential Role in Eukaryotic Translesion Synthesis

(2011) Junjun Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

CRL4Cdt2

(2011) Tarek Abbas et al.   CELL CYCLE

Roles of sequential ubiquitination of PCNA in DNA-damage tolerance

(2011) Weiwei Zhang et al.   FEBS LETTERS

Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligase

(2011) C. G. Havens et al.   GENES & DEVELOPMENT

Studies on Human DNA Polymerase ϵ and GINS Complex and Their Role in DNA Replication

(2011) Vladimir P. Bermudez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation

(2011) Stine Jørgensen et al.   JOURNAL OF CELL BIOLOGY

Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

(2011) Suzanne E. Hile et al.   NUCLEIC ACIDS RESEARCH

Okazaki fragment maturation: nucleases take centre stage

(2011) L. Zheng et al.   Journal of Molecular Cell Biology

The p12 Subunit of Human Polymerase δ Modulates the Rate and Fidelity of DNA Synthesis

(2010) Xiao Meng et al.   BIOCHEMISTRY

Regulation of DNA Polymerase POLD4 Influences Genomic Instability in Lung Cancer

(2010) Q. M. Huang et al.   CANCER RESEARCH

NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by Stabilizing Cdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer Cells

(2010) J. J. Lin et al.   CANCER RESEARCH

PCNA is ubiquitinated by RNF8

(2010) Sufang Zhang et al.   CELL CYCLE

Examination of the expanding pathways for the regulation of p21 expression and activity

(2010) Yong-Sam Jung et al.   CELLULAR SIGNALLING

Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes

(2010) Young-Hoon Kang et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ubiquitin signalling in DNA replication and repair

(2010) Helle D. Ulrich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The eukaryotic replicative DNA polymerases take shape

(2010) Erik Johansson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Roles of POLD4, smallest subunit of DNA polymerase δ, in nuclear structures and genomic stability of human cells

(2009) Qin Miao Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

(2009) Jurgen A. Marteijn et al.   JOURNAL OF CELL BIOLOGY

Human DNA Polymerase   Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

(2009) L. Rey et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells

(2009) Rémy Bétous et al.   MOLECULAR CARCINOGENESIS

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

DNA polymerases at the eukaryotic fork—20 years later

(2009) Youri I. Pavlov et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex

(2008) T. Abbas et al.   GENES & DEVELOPMENT

Polymerase Dynamics at the Eukaryotic DNA Replication Fork

(2008) Peter M. J. Burgers   JOURNAL OF BIOLOGICAL CHEMISTRY

Division of Labor at the Eukaryotic Replication Fork

(2008) Stephanie A. Nick McElhinny et al.   MOLECULAR CELL

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA damage alters DNA polymerase   to a form that exhibits increased discrimination against modified template bases and mismatched primers

(2008) X. Meng et al.   NUCLEIC ACIDS RESEARCH

Dividing the workload at a eukaryotic replication fork

(2008) Thomas A. Kunkel et al.   TRENDS IN CELL BIOLOGY