Enhanced Inflammasome Activity in Systemic Lupus Erythematosus Is Mediated via Type I Interferon-Induced Up-Regulation of Interferon Regulatory Factor 1

Lupus Skin Is Primed for IL-6 Inflammatory Responses through a Keratinocyte-Mediated Autocrine Type I Interferon Loop

(2017) Jasmine N. Stannard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus

(2017) Richard Furie et al.   Arthritis & Rheumatology

Cause and consequences of the activated type I interferon system in SLE

(2016) Maija-Leena Eloranta et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

(2016) Hui Zhang et al.   Journal of Translational Medicine

Dysfunction of endothelial progenitor cells is associated with the type I IFN pathway in patients with polymyositis and dermatomyositis

(2016) Louise Ekholm et al.   RHEUMATOLOGY

MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells

(2016) Xiao Han et al.   Arthritis & Rheumatology

Epidermal injury promotes nephritis flare in lupus-prone mice

(2015) Kaitlyn L. Clark et al.   JOURNAL OF AUTOIMMUNITY

Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells

(2015) Ravichandran Panchanathan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation

(2015) Shuk-Man Ka et al.   ARTHRITIS RESEARCH & THERAPY

Interferon Regulatory Factor 1 Marks Activated Genes and Can Induce Target Gene Expression in Systemic Lupus Erythematosus

(2015) Zhe Zhang et al.   Arthritis & Rheumatology

The inflammasome and lupus

(2014) J. Michelle Kahlenberg et al.   CURRENT OPINION IN RHEUMATOLOGY

Type I Interferon in the Pathogenesis of Lupus

(2014) M. K. Crow   JOURNAL OF IMMUNOLOGY

Cell-Specific Type I IFN Signatures in Autoimmunity and Viral Infection: What Makes the Difference?

(2014) Chieko Kyogoku et al.   PLoS One

Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages

(2014) Lisa T. C. Vogelpoel et al.   Nature Communications

P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

(2013) Jijun Zhao et al.   ARTHRITIS AND RHEUMATISM

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-κB activation

(2013) Jijun Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Deregulated NLRP3 and NLRP1 Inflammasomes and Their Correlations with Disease Activity in Systemic Lupus Erythematosus

(2013) Q. Yang et al.   JOURNAL OF RHEUMATOLOGY

An Essential Role of Caspase 1 in the Induction of Murine Lupus and Its Associated Vascular Damage

(2013) J. Michelle Kahlenberg et al.   Arthritis & Rheumatology

Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis

(2012) Seth G. Thacker et al.   ARTHRITIS AND RHEUMATISM

Polimorphisms in Inflammasome Genes Are Involved in the Predisposition to Systemic Lupus Erythematosus

(2012) Alessandra Pontillo et al.   AUTOIMMUNITY

U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes

(2012) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Gene Profiling of Narrowband UVB–Induced Skin Injury Defines Cellular and Molecular Innate Immune Responses

(2012) Milène Kennedy Crispin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Murine BAFF expression is up-regulated by estrogen and interferons: Implications for sex bias in the development of autoimmunity

(2012) Ravichandran Panchanathan et al.   MOLECULAR IMMUNOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Inflammasome Activation of IL-18 Results in Endothelial Progenitor Cell Dysfunction in Systemic Lupus Erythematosus

(2011) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Interferon-α accelerates murine systemic lupus erythematosus in a T cell-dependent manner

(2010) Zheng Liu et al.   ARTHRITIS AND RHEUMATISM

Lupus Serum IgG Induces Skin Inflammation through the TNFR1 Signaling Pathway

(2010) G.-M. Deng et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

P2X7 Receptor-Stimulated Secretion of MHC Class II-Containing Exosomes Requires the ASC/NLRP3 Inflammasome but Is Independent of Caspase-1

(2009) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Deficiency of Type I IFN Receptor in Lupus-Prone New Zealand Mixed 2328 Mice Decreases Dendritic Cell Numbers and Activation and Protects from Disease

(2009) H. Agrawal et al.   JOURNAL OF IMMUNOLOGY