Cause and consequences of the activated type I interferon system in SLE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes

(2015) Dag Leonard et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular traps and their role in the development of chronic inflammation and autoimmunity

(2015) Boris Pinegin et al.   AUTOIMMUNITY REVIEWS

A volcanic explosion of autoantibodies in systemic lupus erythematosus: A diversity of 180 different antibodies found in SLE patients

(2015) Gal Yaniv et al.   AUTOIMMUNITY REVIEWS

B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production

(2015) Shaun W Jackson et al.   CURRENT OPINION IN IMMUNOLOGY

B cells responses and cytokine production are regulated by their immune microenvironment

(2015) Monica I. Vazquez et al.   CYTOKINE

Anti-BDCA2 monoclonal antibody inhibits plasmacytoid dendritic cell activation through Fc-dependent and Fc-independent mechanisms

(2015) A. Pellerin et al.   EMBO Molecular Medicine

Drug-induced lupus

(2015) Robert L Rubin   Expert Opinion On Drug Safety

IFN-  production by plasmacytoid dendritic cell associations with polymorphisms in gene loci related to autoimmune and inflammatory diseases

(2015) O. Berggren et al.   HUMAN MOLECULAR GENETICS

Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo

(2015) Marc Clement et al.   JOURNAL OF AUTOIMMUNITY

UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)

(2015) Michael G. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

(2015) James Bentham et al.   NATURE GENETICS

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Lupus erythematosus revisited

(2015) Annegret Kuhn et al.   Seminars in Immunopathology

Targeting of type I interferon in systemic autoimmune diseases

(2015) Mary K. Crow et al.   Translational Research

The molecular basis for functional plasticity in type I interferon signaling

(2015) Gideon Schreiber et al.   TRENDS IN IMMUNOLOGY

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources

(2015) Jonatan Leffler et al.   ARTHRITIS RESEARCH & THERAPY

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Advances in understanding the role of type I interferons in systemic lupus erythematosus

(2014) Mary K. Crow   CURRENT OPINION IN RHEUMATOLOGY

Advances in lupus genetics and epigenetics

(2014) Yun Deng et al.   CURRENT OPINION IN RHEUMATOLOGY

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

(2014) R. E. Rigby et al.   EMBO JOURNAL

Post-Transcriptional Regulation of Interferons and Their Signaling Pathways

(2014) Ram Savan   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Ultraviolet radiation and systemic lupus erythematosus

(2014) M Barbhaiya et al.   LUPUS

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Non-histone protein methylation as a regulator of cellular signalling and function

(2014) Kyle K. Biggar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cardiovascular disease in lupus

(2013) Jason S. Knight et al.   CURRENT OPINION IN RHEUMATOLOGY

Genetic susceptibility to SLE: Recent progress from GWAS

(2013) Yong Cui et al.   JOURNAL OF AUTOIMMUNITY

Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice

(2013) X. Sun et al.   JOURNAL OF IMMUNOLOGY

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

B lymphocytes enhance interferon-α production by plasmacytoid dendritic cells

(2012) Olof Berggren et al.   ARTHRITIS AND RHEUMATISM

Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis

(2012) Seth G. Thacker et al.   ARTHRITIS AND RHEUMATISM

Disease Mechanisms in Rheumatology-Tools and Pathways: Plasmacytoid Dendritic Cells and Their Role in Autoimmune Rheumatic Diseases

(2012) Maija-Leena Eloranta et al.   ARTHRITIS AND RHEUMATISM

Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New

(2012) Alessia Alunno et al.   Clinical & Developmental Immunology

Complement, interferon and lupus

(2012) Keith B Elkon et al.   CURRENT OPINION IN IMMUNOLOGY

The genetics of type I interferon in systemic lupus erythematosus

(2012) Paola G Bronson et al.   CURRENT OPINION IN IMMUNOLOGY

The interferon signature in autoimmune diseases

(2012) Lars Rönnblom et al.   CURRENT OPINION IN RHEUMATOLOGY

Lupus: How much “complexity” is really (just) genetic heterogeneity?

(2011) Yanick J. Crow   ARTHRITIS AND RHEUMATISM

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

(2011) H. Travis Ichikawa et al.   ARTHRITIS AND RHEUMATISM

Systemic lupus erythematosus one disease or many?

(2011) N. Agmon-Levin et al.   AUTOIMMUNITY REVIEWS

IFN-  Production by Plasmacytoid Dendritic Cells Stimulated with RNA-Containing Immune Complexes Is Promoted by NK Cells via MIP-1  and LFA-1

(2011) N. Hagberg et al.   JOURNAL OF IMMUNOLOGY

Systems Biology of Interferon Responses

(2011) Paul Hertzog et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

The type I interferon system in the development of lupus

(2011) Lars Rönnblom et al.   SEMINARS IN IMMUNOLOGY

Immunodeficiency and autoimmunity: lessons from systemic lupus erythematosus

(2011) Alexandros P. Grammatikos et al.   TRENDS IN MOLECULAR MEDICINE

Systemic lupus erythematosus: Clinical presentations

(2010) Paul P. Smith et al.   AUTOIMMUNITY REVIEWS

Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance

(2010) Melissa Swiecki et al.   IMMUNOLOGICAL REVIEWS

C1q Deficiency Leads to the Defective Suppression of IFN-  in Response to Nucleoprotein Containing Immune Complexes

(2010) D. M. Santer et al.   JOURNAL OF IMMUNOLOGY

Evidence for a Pathophysiological Role of Keratinocyte-Derived Type III Interferon (IFNλ) in Cutaneous Lupus Erythematosus

(2010) Sabine Zahn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

PECAM-1: Conflicts of interest in inflammation

(2010) Jamie R. Privratsky et al.   LIFE SCIENCES

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C1q inhibits immune complex-induced interferon-α production in plasmacytoid dendritic cells: A novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

(2009) Christian Lood et al.   ARTHRITIS AND RHEUMATISM

Regulation of the interferon-α production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

(2009) Maija-Leena Eloranta et al.   ARTHRITIS AND RHEUMATISM

Association of the IRF5 risk haplotype with high serum interferon-α activity in systemic lupus erythematosus patients

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM