Comparative effects of a candidate modified-risk tobacco product Aerosol and cigarette smoke on human organotypic small airway cultures: a systems toxicology approach

Establishment and characterization of an in vitro human small airway model (SmallAir™)

(2017) Song Huang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study

(2017) Filippo Zanetti et al.   FOOD AND CHEMICAL TOXICOLOGY

Characterization of the Vitrocell® 24/48 aerosol exposure system for its use in exposures to liquid aerosols

(2017) Sandro Steiner et al.   TOXICOLOGY IN VITRO

A systems toxicology approach for comparative assessment: Biological impact of an aerosol from a candidate modified-risk tobacco product and cigarette smoke on human organotypic bronchial epithelial cultures

(2017) Anita R. Iskandar et al.   TOXICOLOGY IN VITRO

Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures

(2016) Filippo Zanetti et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Simulation of aerosol dynamics and deposition of combustible and electronic cigarette aerosols in the human respiratory tract

(2016) Lukas Pichelstorfer et al.   JOURNAL OF AEROSOL SCIENCE

Adaptive homeostasis

(2016) Kelvin J.A. Davies   MOLECULAR ASPECTS OF MEDICINE

Evaluation of the Tobacco Heating System 2.2. Part 3: Influence of the tobacco blend on the formation of harmful and potentially harmful constituents of the Tobacco Heating System 2.2 aerosol

(2016) Jean-Pierre Schaller et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program

(2016) Maurice R. Smith et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol

(2016) Jean-Pierre Schaller et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In vitro toxicity testing of cigarette smoke based on the air-liquid interface exposure: A review

(2016) Xiang Li   TOXICOLOGY IN VITRO

Hedgehog: the key to maintaining adult lung repair and regeneration

(2016) Amruthansh Sriperumbudur et al.   Journal of Cell Communication and Signaling

A mechanistic redefinition of adverse effects – a key step in the toxicity testing paradigm shift

(2016) Kim Boekelheide   ALTEX-Alternatives to Animal Experimentation

Cilia Dysfunction in Lung Disease

(2015) Ann E. Tilley et al.   Annual Review of Physiology

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration

(2015) Tien Peng et al.   NATURE

Orchestrating high-throughput genomic analysis with Bioconductor

(2015) Wolfgang Huber et al.   NATURE METHODS

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data

(2015) Iwona Wilk-Zasadna et al.   TOXICOLOGY

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

(2015) Stéphanie Boué et al.   Database-The Journal of Biological Databases and Curation

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

(2014) Florian Martin et al.   BMC BIOINFORMATICS

Systems Toxicology: From Basic Research to Risk Assessment

(2014) Shana J. Sturla et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Characterization of the Vitrocell® 24/48 in vitroaerosol exposure system using mainstream cigarette smoke

(2014) Shoaib Majeed et al.   Chemistry Central Journal

The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure

(2014) Marja Talikka et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Systems toxicology

(2014) Thomas HArtung   ALTEX-Alternatives to Animal Experimentation

Case study: the role of mechanistic network models in systems toxicology

(2013) Julia Hoeng et al.   DRUG DISCOVERY TODAY

Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function

(2013) Petr V. Nazarov et al.   NUCLEIC ACIDS RESEARCH

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models

(2013) Ty M. Thomson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2: Friend and Foe in Preventing Cigarette Smoking-Dependent Lung Disease

(2012) Thomas Müller et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

APCluster: an R package for affinity propagation clustering

(2011) U. Bodenhofer et al.   BIOINFORMATICS

A network-based approach to quantifying the impact of biologically active substances

(2011) Julia Hoeng et al.   DRUG DISCOVERY TODAY

A framework for oligonucleotide microarray preprocessing

(2010) Benilton S. Carvalho et al.   BIOINFORMATICS

Frozen robust multiarray analysis (fRMA)

(2010) M. N. McCall et al.   BIOSTATISTICS

Toxicity Testing in the 21st Century: A Vision and a Strategy

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

The small airways and distal lung compartment in asthma and COPD: a time for reappraisal

(2009) M. Contoli et al.   ALLERGY

Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency

(2009) Noam A. Cohen et al.   LARYNGOSCOPE

arrayQualityMetrics—a bioconductor package for quality assessment of microarray data

(2008) Audrey Kauffmann et al.   BIOINFORMATICS