Article
Plant Sciences
Stanislav Sukhikh, Svetlana Noskova, Artem Pungin, Svetlana Ivanova, Liubov Skrypnik, Evgeny Chupakhin, Olga Babich
Summary: The study shows that extracts from Cotinus coggygria contain a variety of bioactive substances which exhibit anticancer, antigenotoxic, and antimicrobial properties, along with high antioxidant activity. The extraction process involves the use of ethyl alcohol with a hydromodule of 1:5 at a temperature of 60 degrees C for 60 minutes. The extracts were found to be safe from heavy metals, pesticides, aflatoxin B1, radionuclides, pathogens, and opportunistic microorganisms.
Article
Green & Sustainable Science & Technology
Taras Hutsol, Olesia Priss, Liudmyla Kiurcheva, Maryna Serdiuk, Katarzyna Panasiewicz, Monika Jakubus, Wieslaw Barabasz, Karolina Furyk-Grabowska, Mykola Kukharets
Summary: The study found that Ukrainian mint plants are rich in phytonutrients and can maintain their stability during drying and freezing processes. Drying increases the concentration of biologically active substances in mint, making it suitable as an ingredient for functional foods. However, drying leads to significant losses of ascorbic acid, carotenoids, chlorophylls, and phenols. Peppermint and spearmint demonstrate higher stability of biologically active compounds, while field mint and spearmint samples show the best stability after freezing. Therefore, targeted selection of mint types and varieties before processing can maximize the preservation of biologically active substances, increase the phytonutrient content in finished products, and prevent hidden hunger.
Article
Food Science & Technology
Zhi Wang, Yanqing Li, Zhichao Hui, Jinle Liu, Xiaomin Guo, Zhen Chen, Zhidan Yu, Anqi Zhao, Shilei Wang, Yafan Cai, Ning He, Jingliang Xu, Wei Zhuang, Hanjie Ying
Summary: Organic selenium nanoparticles (EPS-SeNPs) were synthesized using extracellular polymeric substances (EPS) fermented from waste cane molasses, and exhibited good stability, antibacterial activity, and antioxidant activity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Zhongcan Peng, Jun He, Yungchi Cheng, Jiekun Xu, Weiku Zhang
Summary: Secoiridoids are natural products with a diverse range of biological activities, including neuroprotection, anti-inflammatory effects, antidiabetic properties, hepatoprotection, and analgesic activities. They can also target multiple molecular pathways involved in tumorigenesis, making them potential precursors for anticancer drug development. This review provides an update on the occurrence, structural diversity, bioactivities, and synthesis of naturally occurring secoiridoids from January 2011 to December 2020, aiming to fill the gap in comprehensive review and open new avenues for pharmacological investigation and drug development based on these compounds.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Chemistry, Medicinal
Mengjie Liu, Barbara F. White, Praveen Praveen, Wenyi Li, Feng Lin, Hongkang Wu, Rong Li, Carlie Delaine, Briony E. Forbes, John D. Wade, Mohammed Akhter Hossain
Summary: The study reported an efficient synthesis method for a novel disulfide dimer of human insulin, which has a similar structure to native insulin and comparable affinity to both the insulin receptor and insulin-like growth factor-1 receptor. In insulin tolerance tests, the dimeric insulin showed equipotency to Actrapid and a sustained duration of action surpassing that of Actrapid and Glargine.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biodiversity Conservation
Mo Wang, Yingxin Li, Haojun Yuan, Shiqi Zhou, Yuankai Wang, Rana Muhammad Adnan Ikram, Jianjun Li
Summary: This study uses explainable Artificial Intelligence methods to assess urban flooding risks and finds that urban morphology has a significant impact on flood susceptibility, with building volume being a critical factor during severe flooding. It suggests optimizing building configurations to reduce flood risks and provides specific ranges for building volume.
ECOLOGICAL INDICATORS
(2023)
Article
Biology
Olga Babich, Svetlana Ivanova, Elena Ulrikh, Alexander Popov, Viktoria Larina, Andrej Frolov, Alexander Prosekov
Summary: This study investigated the impact of different extraction methods on the chemical composition and biologically active properties of Glycyrrhiza glabra extract samples, revealing that extracts obtained by Soxhlet extraction with methanol had the highest yield and concentration of biologically active substances, showing inhibitory effects on bacteria and oxidative stress.
Article
Chemistry, Multidisciplinary
Diana Saribekova, Oleksandra Kunik, Ruslana Harhaun, Ludmila Saleba, Giuseppe Cavallaro
Summary: Based on theoretical studies, the authors propose the use of silicone polymers for the extraction of biologically active substances from vegetable raw materials. The biological molecules do not interact with the silicones, maintaining their properties post-extraction. The combination of different silicone polymers has been shown to improve extraction efficiency, providing useful insights for cosmetic emulsion formulation.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Anthi Petrou, Maria Fesatidou, Athina Geronikaki
Summary: Thiazole is a valuable pharmacophore nucleus with a wide range of biological activities, including antioxidant, analgesic, antimicrobial, antihypertensive, anti-inflammatory, and antipsychotic properties. Recent literature review identified and critically analyzed nearly 124 research articles on the synthesis and biological activities of thiazoles derivatives in the past 5 years.
Article
Chemistry, Multidisciplinary
Svetlana Kalinina, Katharina Steinert, Nina Berg, Dmitrii V. Kalinin, Annika Jagels, Ernst-Ulrich Wuerthwein, Hans-Ulrich Humpf
Summary: The phenylspirodrimanes from Stachybotrys chartarum are a group of structurally diverse meroterpenoids. They were synthesized into biologically active lactams, which showed inhibitory activity against certain serine proteases and modulatory effect on blood coagulation.
Article
Computer Science, Hardware & Architecture
Usha Patel, Vibha Patel
Summary: In recent years, deep neural networks have been successfully applied to classify hyperspectral images (HSIs). However, training deep neural networks requires a large amount of labeled datasets, which are costly and time-consuming to acquire in HSIs. Active learning (AL) is a technique that selects a small subset of data for annotation to improve classifier accuracy. Most AL methods are based on statistical approaches, but they have limitations and variable performance. Therefore, a reinforced pool-based deep active learning (RPDAL) approach is proposed, which utilizes reinforcement learning (RL) to train an agent for informative sample selection. The proposed approach achieves better classification performance than other AL techniques when evaluated on publicly available datasets.
JOURNAL OF SUPERCOMPUTING
(2023)
Review
Biochemistry & Molecular Biology
Prasenjit Maity, Ipsita K. Sen, Indranil Chakraborty, Soumitra Mondal, Harekrishna Bar, Sunil K. Bhanja, Soumitra Mandal, Gajendra Nath Maity
Summary: Mushroom polysaccharides have immunomodulating, antimicrobial, antioxidant, anticancer, and antitumor properties, and their mechanism of action is to stimulate immune responses. Research on the structure and biological properties of mushroom polysaccharides is of potential significance for the development of therapeutic materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Food Science & Technology
Diego Morales, Marta Miguel, Marta Garces-Rimon
Summary: Research interest in underexploited foods has increased in the last two decades, with pseudocereals like quinoa, amaranth, chia, and buckwheat being highlighted for their nutritional value and bioactive compounds. These pseudocereals have been found to possess various health benefits, such as anticancer, antioxidant, anti-inflammatory, hypocholesterolemic, and antihypertensive properties, leading to a growing importance of these crops. The purpose of this study was to provide a comprehensive review of the biological activities of peptides and protein hydrolysates derived from the most extensively studied pseudocereals.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Environmental Sciences
Ana Isabel Diaz, Adriana Laca, Mario Diaz
Summary: This study evaluated the use of P. chrysosporium to treat landfill leachate with high load of refractory compounds. The results showed that fungal treatment was effective in reducing COD and color. pH control was crucial for the treatment, and the addition of carbon and nitrogen sources improved the removal efficiency.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Review
Chemistry, Medicinal
Fatemeh Salehian, Hamid Nadri, Leili Jalili-Baleh, Leila Youseftabar-Miri, Syed Nasir Abbas Bukhari, Alireza Foroumadi, Tuba Tuylu Kucukkilinc, Mohammad Sharifzadeh, Mehdi Khoobi
Summary: The combination of heterocycles offers a new opportunity to create novel multicyclic compounds with improved biological activity, and 3,4-heterocycle-fused coumarins have shown outstanding potential in the field of biological activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Bjoern Titz, Raffaella M. Gadaleta, Giuseppe Lo Sasso, Ashraf Elamin, Kim Ekroos, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Medicine, General & Internal
Julia Hoeng, Serge Maeder, Patrick Vanscheeuwijck, Manuel C. Peitsch
INTERNAL AND EMERGENCY MEDICINE
(2019)
Review
Medicine, General & Internal
Timothy M. Thomson, Cristina Balcells, Marta Cascante
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyi Zhao, Filippo Zanetti, Lin Wang, Jie Pan, Shoaib Majeed, Hans Malmstrom, Manuel C. Peitsch, Julia Hoeng, Yanfang Ren
JOURNAL OF DENTISTRY
(2019)
Review
Oncology
Leire Pedrosa, Francis Esposito, Timothy M. Thomson, Joan Maurel
Article
Hematology
Timothy M. Thomson, Emily Toscano-Guerra, Ernesto Casis, Rosanna Paciucci
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Chemistry, Medicinal
Ainhoa Alzualde, Oihane Jaka, Diogo A. R. S. Latino, Omar Alijevic, Inaki Iturria, Jorge Hurtado de Mendoza, Pavel Pospisil, Stefan Frentzel, Manuel C. Peitsch, Julia Hoeng, Kyoko Koshibu
Summary: The study found nicotine to be the most effective anxiolytic alkaloid tested, with other natural alkaloids also potentially regulating anxiety.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Immunology
Hasmik Yepiskoposyan, Manuel C. Peitsch, Marja Talikka
Summary: Any stressor that disrupts cellular homeostasis can trigger an inflammatory response, with inflammasomes playing a crucial role in this process. Causal biological network models can be used to interpret transcriptomic data and understand inflammasome activation.
INTERNATIONAL JOURNAL OF INFLAMMATION
(2022)
Article
Biology
Sonia Ouadi, Nicolas Sierro, Simon Goepfert, Lucien Bovet, Gaetan Glauser, Armelle Vallat, Manuel C. Peitsch, Felix Kessler, Nikolai V. IVanov
Summary: This study compares the newly assembled clove genome with Eucalyptus grandis to investigate genome evolution in the Myrtaceae family and identifies potential genes involved in the biosynthesis of eugenol. The findings provide important genomic resources for clove research and the Myrtaceae family.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kunhua Li, Olena S. Tokareva, Ty M. Thomson, Sebastian C. T. Wahl, Tara L. Travaline, Jessica D. Ramirez, Santosh K. Choudary, Sorabh Agarwal, Ward G. Walkup IV, Tivoli J. Olsen, Matthew J. Brennan, Gregory L. Verdine, John H. McGee
Summary: The alpha-helix is a common protein surface recognition motif that has potential in drug discovery. This study reports a general and rapid screening method using Helicon phage display libraries and next-generation sequencing to map alpha-helix binding sites on a wide range of proteins. Multiple alpha-helix recognition sites were discovered, and the binding molecules at these sites were shown to inhibit protein-protein interactions, enzymatic activity, and induce conformational rearrangements.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Food Science & Technology
Stephanie Johne, Marco Van der Toorn, Anita R. Iskandar, Shoaib Majeed, Laura O. Torres, Julia Hoeng, Manuel C. Peitsch
Summary: Homemade e-liquids and power-adjustable vaping devices may pose higher risks than commercial formulations and fixed-power devices. This study examined the toxicity of homemade e-liquids containing various chemicals and power settings using human cell cultures. The results showed that certain chemicals in the e-liquids caused cytotoxicity and disrupted epithelial function, while higher power settings generated higher levels of toxic compounds. These findings suggest the need for toxicity assessments for both e-liquid formulations and their aerosols.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Catherine Verhaeghe, Marja Talikka, Alain Sewer, Nicolas Sierro, Mehdi Auberson, Dariusz Peric, David Bornand, Remi Dulize, Emmanuel Guedj, Patrick Nef, Sebastien P. Tabruyn, Julia Hoeng, Manuel C. Peitsch, Giuseppe Lo Sasso
Summary: This study investigated the potential anti-inflammatory activities of tobacco alkaloids nicotine and anatabine in a fully humanized UC mouse model. The results showed that nicotine significantly reduced acute colitis symptoms and improved colitis-specific endpoints. Anatabine also demonstrated similar effectiveness, although weaker or not significant. Gene expression analysis provided insights into the possible mechanism by which nicotine attenuated DSS-induced colitis in humanized mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Maria Nuria Peralta-Moreno, Vanessa Anton-Munoz, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Olga Abian, Adrian Velazquez-Campoy, Timothy M. Thomson, Jose Manuel Granadino-Roldan, Claudia Machicado, Jaime Rubio-Martinez
Summary: Since the outbreak of the COVID-19 pandemic, there have been over 750 million reported cases of COVID-19 caused by SARS-CoV-2. In order to find effective treatments, intensive research has been conducted on therapeutic agents derived from pharmaceutical repositioning or natural products. This study focuses on identifying inhibitors for the SARS-CoV-2 M-pro main protease dimer using virtual screening of natural compounds derived from Peruvian flora. The compound Hyperoside displayed inhibitory activity against M-pro in vitro, with a K-i value lower than 20 μM, possibly through allosteric modulation.
Article
Biochemistry & Molecular Biology
David Bovard, Marco van der Toorn, Walter K. Schlage, Samuel Constant, Kasper Renggli, Manuel C. Peitsch, Julia Hoeng
Summary: This study confirms the efficacy and safety of Iota-carrageenan nasal spray in preventing SARS-CoV-2 infection. The nasal spray can inhibit the virus from entering and replicating in cells, and it does not cause toxicity or harm to the respiratory epithelium.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Valerie Francoise Smolders, Erika Zodda, Paul H. A. Quax, Marina Carini, Joan Albert Barbera, Timothy M. Thomson, Olga Tura-Ceide, Marta Cascante
FRONTIERS IN MOLECULAR BIOSCIENCES
(2019)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
