Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases

SZT2 dictates GATOR control of mTORC1 signalling

(2017) Min Peng et al.   NATURE

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

(2017) Rachel L. Wolfson et al.   NATURE

GATOR1 complex: the common genetic actor in focal epilepsies

(2016) Sara Baldassari et al.   JOURNAL OF MEDICAL GENETICS

Dynamic relocation of the TORC1–Gtr1/2–Ego1/2/3 complex is regulated by Gtr1 and Gtr2

(2016) Shintaro Kira et al.   MOLECULAR BIOLOGY OF THE CELL

The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast

(2016) Ning Ma et al.   PLoS One

Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose

(2015) Tomoyuki Hatano et al.   CELL CYCLE

Multiple amino acid sensing inputs to mTORC1

(2015) Mitsugu Shimobayashi et al.   CELL RESEARCH

Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

(2015) Katie Powis et al.   CELL RESEARCH

Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast

(2015) Qingbin Liu et al.   PLoS One

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy

(2014) Shintaro Kira et al.   Autophagy

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Rag GTPases are cardioprotective by regulating lysosomal function

(2014) Young Chul Kim et al.   Nature Communications

Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter

(2014) A. Nakashima et al.   Biology Open

TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

(2013) Charalampos Rallis et al.   AGING CELL

SEACing the GAP that nEGOCiates TORC1 activation

(2013) Nicolas Panchaud et al.   CELL CYCLE

TORC1 Signaling Is Governed by Two Negative Regulators in Fission Yeast

(2013) N. Ma et al.   GENETICS

Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging

(2013) Noriko Oshiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fission yeast  -arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters

(2013) Y. Nakase et al.   JOURNAL OF CELL SCIENCE

Isp7 Is a Novel Regulator of Amino Acid Uptake in the TOR Signaling Pathway

(2013) Dana Laor et al.   MOLECULAR AND CELLULAR BIOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

(2013) N. Panchaud et al.   Science Signaling

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

TORC1 of fission yeast is rapamycin-sensitive

(2012) Terunao Takahara et al.   GENES TO CELLS

The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast

(2012) N. Valbuena et al.   JOURNAL OF CELL SCIENCE

Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase

(2012) A. Nakashima et al.   JOURNAL OF CELL SCIENCE

A Conserved Coatomer-related Complex Containing Sec13 and Seh1 Dynamically Associates With the Vacuole inSaccharomyces cerevisiae

(2011) Svetlana Dokudovskaya et al.   MOLECULAR & CELLULAR PROTEOMICS

Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation

(2011) Xi Wu et al.   MOLECULAR BIOLOGY OF THE CELL

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe

(2011) N. Ikai et al.   Open Biology

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Structural Conservation of Components in the Amino Acid Sensing Branch of the TOR Pathway in Yeast and Mammals

(2010) Konstantin Kogan et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinctive Responses to Nitrogen Starvation in the Dominant Active Mutants of the Fission Yeast Rheb GTPase

(2009) T. Murai et al.   GENETICS

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex

(2009) Taavi K. Neklesa et al.   PLoS Genetics

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast

(2008) Paul-Joseph Aspuria et al.   MOLECULAR GENETICS AND GENOMICS

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE