Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells

(2017) Bogdan Beirowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

(2017) Monica Ghidinelli et al.   PLOS BIOLOGY

Schwann cells–axon interaction in myelination

(2016) Carla Taveggia   CURRENT OPINION IN NEUROBIOLOGY

Niacin‐mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination

(2016) Alessandra Bolino et al.   EMBO Molecular Medicine

Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation

(2016) Juxiang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling

(2016) E. S. Mathews et al.   JOURNAL OF NEUROSCIENCE

Akt Regulates Axon Wrapping and Myelin Sheath Thickness in the PNS

(2016) E. Domenech-Estevez et al.   JOURNAL OF NEUROSCIENCE

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

(2016) Minqing Jiang et al.   Nature Communications

CNS Myelin Wrapping Is Driven by Actin Disassembly

(2015) J. Bradley Zuchero et al.   DEVELOPMENTAL CELL

Actin Filament Turnover Drives Leading Edge Growth during Myelin Sheath Formation in the Central Nervous System

(2015) Schanila Nawaz et al.   DEVELOPMENTAL CELL

New insights on schwann cell development

(2015) Kelly R. Monk et al.   GLIA

How Schwann Cells Sort Axons

(2015) M. Laura Feltri et al.   NEUROSCIENTIST

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination

(2014) M. E. Sheean et al.   GENES & DEVELOPMENT

Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system

(2014) Bradley A. Heller et al.   JOURNAL OF CELL BIOLOGY

Oligodendrocyte Precursor Cell-Intrinsic Effect of Rheb1 Controls Differentiation and Mediates mTORC1-Dependent Myelination in Brain

(2014) Y. Zou et al.   JOURNAL OF NEUROSCIENCE

Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination

(2014) K. K. Bercury et al.   JOURNAL OF NEUROSCIENCE

Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination

(2014) S. E. Wahl et al.   JOURNAL OF NEUROSCIENCE

Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

(2014) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A

(2014) Robert Fledrich et al.   NATURE MEDICINE

Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice

(2014) Jessica Nicks et al.   NEUROBIOLOGY OF DISEASE

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

(2014) Lin Mei et al.   NEURON

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

(2014) H. Tang et al.   Science Signaling

mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells

(2014) Camilla Norrmén et al.   Cell Reports

mTOR: A Link from the Extracellular Milieu to Transcriptional Regulation of Oligodendrocyte Development

(2013) Teresa L. Wood et al.   ASN Neuro

The Regulation of Cell Size

(2013) Alison C. Lloyd   CELL

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

Sustained Activation of ERK1/2 MAPK in Oligodendrocytes and Schwann Cells Enhances Myelin Growth and Stimulates Oligodendrocyte Progenitor Expansion

(2013) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

Genetic disruption ofPtenin a novel mouse model of tomaculous neuropathy

(2012) Sandra Goebbels et al.   EMBO Molecular Medicine

Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

(2012) D. L. Sherman et al.   JOURNAL OF NEUROSCIENCE

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

(2011) Nicole A. Neuman et al.   EMBO Molecular Medicine

WIPI1 Coordinates Melanogenic Gene Transcription and Melanosome Formation via TORC1 Inhibition

(2011) Hsiang Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-WASP is required for membrane wrapping and myelination by Schwann cells

(2011) Nurit Novak et al.   JOURNAL OF CELL BIOLOGY

Specific Functions for ERK/MAPK Signaling during PNS Development

(2011) Jason M. Newbern et al.   NEURON

Molecular mechanisms regulating myelination in the peripheral nervous system

(2011) Jorge A. Pereira et al.   TRENDS IN NEUROSCIENCES

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

(2010) Roman Chrast et al.   JOURNAL OF LIPID RESEARCH

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination

(2010) L. Cotter et al.   SCIENCE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

mTOR and cancer: many loops in one pathway

(2009) Alejo Efeyan et al.   CURRENT OPINION IN CELL BIOLOGY

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

The molecular machinery of myelin gene transcription in Schwann cells

(2008) John Svaren et al.   GLIA

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

(2008) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE