Article
Pharmacology & Pharmacy
Huihao Tang, Lili Yang, Longlong Wu, Huimin Wang, Kaixian Chen, Huali Wu, Yiming Li
Summary: Kaempferol promotes melanogenesis and melanocyte growth by regulating dendritic growth and melanosome quantity, maturation, and transport in melanocytes via the P38/ERK MAPK and PI3K/AKT signaling pathways.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Oncology
Jung Min Lee, Jung Ok Lee, Yujin Kim, You Na Jang, A. Yeon Park, Su-Young Kim, Hye Sung Han, Beom Joon Kim, Kwang Ho Yoo
Summary: Exosomes derived from BJ-5ta effectively prevent melanogenesis by regulating multiple signaling pathways, inhibiting melanosome transport and have potential clinical applications in treating hyperpigmentation disorders.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Vitor Teixeira, Telma S. Martins, William A. Prinz, Vitor Costa
Summary: The study reveals that TORC1 regulates LD formation at a transcriptional level by targeting DGA1 expression, while cytosolic pH (pHc) acts as a second messenger regulating the localization and activity of the major transcription factor repressor Opi1, controlling the metabolic switch between phospholipid metabolism and lipid storage. This work highlights unknown molecular mechanisms connecting nutrient availability and pHc to LD formation through a transcriptional circuit regulated by major signaling transduction pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qiutan Yang, Shi-Lei Xue, Chii Jou Chan, Markus Rempfler, Dario Vischi, Francisca Mauer-Gutierrez, Takashi Hiiragi, Edouard Hannezo, Prisca Liberali
Summary: This study reveals the simultaneous occurrence of crypt formation and reduction in lumen volume in intestinal organoids derived from single cells. By developing a 3D biophysical model and utilizing multiple mechanical perturbations, it demonstrates the synergistic effects of actomyosin-driven crypt apical contraction and villus basal tension with lumen volume reduction in driving crypt morphogenesis. Additionally, a sodium/glucose cotransporter specific to differentiated enterocytes was identified, which modulates lumen volume reduction through cell swelling in the villus region.
NATURE CELL BIOLOGY
(2021)
Article
Dermatology
Xuanjin Wei, Min Huang, Yi Yang, Yali Liu, Sumin Chi, Chengxin Li
Summary: Recent investigations have revealed that the Rab family of GTPases plays a role in all aspects of melanogenesis. However, the specific role of Rab23, a GTPase that regulates the endocytic pathway in eukaryotic cells, in melanogenesis has not been explored. In this study, we found that downregulating Rab23 expression inhibited UVB-induced melanogenesis by reducing melanin levels, tyrosinase activity, and expression of melanogenesis-related proteins. Rab23 was found to colocalize with mature melanosomes and its downregulation led to abnormal melanosome accumulation around the nucleus. These findings suggest that Rab23 is involved in melanin synthesis and melanosome transport by modulating the PKA/CREB/MITF pathway, which is critical for UVB-induced melanogenesis.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Jung Liu, Jia-Ling Lyu, Yueh-Hsiung Kuo, Chen-Yuan Chiu, Kuo-Chiang Wen, Hsiu-Mei Chiang
Summary: DBL, derived from fungi, shows strong antioxidative activity and inhibits melanin production by regulating multiple signaling pathways. It acts as a depigmenting agent in whitening cosmetics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mark R. Cronan, Erika J. Hughes, W. Jared Brewer, Gopinath Viswanathan, Emily G. Hunt, Bindu Singh, Smriti Mehra, Stefan H. Oehlers, Simon G. Gregory, Deepak Kaushal, David M. Tobin
Summary: This study reveals that in tuberculosis infection, type 2 immune signals mediated by stat6 are crucial for macrophage epithelialization and granuloma formation, working in conjunction with type 1 immune responses to impact the structure of granulomas.
Article
Plant Sciences
Takuhiro Uto, Nguyen Huu Tung, Yukihiro Shoyama
Summary: In this study, the diarylheptanoids Hirsutanone (Hir) and oregonin (Ore) were found to inhibit melanin synthesis in both B16-F1 murine melanoma cells and normal human epidermal melanocytes (HEMn-DP). Hir was more effective in suppressing melanin synthesis and it achieved this by reducing tyrosinase activity and inhibiting the CREB/MITF pathway.
Article
Cell Biology
Jia-Nan Wang, Fang Wang, Jing Ke, Zeng Li, Chuan-Hui Xu, Qin Yang, Xin Chen, Xiao-Yan He, Yuan He, Xiao-Guo Suo, Chao Li, Ju-Tao Yu, Ling Jiang, Wei-Jian Ni, Juan Jin, Ming-Ming Liu, Wei Shao, Chen Yang, Qian Gong, Hai-Yong Chen, Jun Li, Yong-Gui Wu, Xiao-Ming Meng
Summary: The role of N-6-methyladenosine (m6A) modifications in renal diseases, particularly acute kidney injury (AKI), is still largely unknown. In this study, the researchers investigated the role of N-6-adenosine-methyltransferase-like 3 (METTL3) in AKI and found that its expression is elevated in renal tubules. They discovered that silencing METTL3 alleviated renal inflammation and programmed cell death in tubular epithelial cells (TECs) in response to stimulation, while overexpression of METTL3 had the opposite effects. Conditional knockout of METTL3 in mice also attenuated renal dysfunction, injury, and inflammation induced by AKI. Furthermore, the researchers identified TAB3 as a target of METTL3 and explored its proinflammatory effects. They also investigated the therapeutic potential of inhibiting METTL3 using an inhibitor called Cpd-564. Overall, they concluded that the METTL3/TAB3 axis may be a potential target for the treatment of AKI.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Xianlin Zhao, Rajwali Khan, Guo Hongfang, Sayed Haidar Abbas Raza, Amel Ayari-Akkari, Gehan Othman, Ahmed Mohajja Alshammari, Bandar Hamad Aloufi, Khulood Fahad Alabbosh, Wasimah B. Alshammari, Zan Linsen
Summary: In this study, sequencing of the TORC1 prompter region identified three SNPs at specific loci, which were found to be associated with body measurement and carcass quality traits in Qinchuan beef cattle.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Afreen Jailani, Bilal Ahmed, Jin-Hyung Lee, Jintae Lee
Summary: This study demonstrates the ability of tannic acid to inhibit the growth and biofilm formation of Agrobacterium tumefaciens. It also shows that tannic acid does not significantly affect plant seed germination.
Article
Biology
Qingqing Guan, Zhaosu Chen, Fang Yu, Lingling Liu, Yuanyong Huang, Gang Wei, Cheng-Ming Chiang, Jiemin Wong, Jiwen Li
Summary: By using a series of MYC mutants, we found that MYC can promote global transcription and enhance serine 2 phosphorylation of RNA polymerase II C-terminal domain, even when deficient in DNA binding or known transcriptional activation activities. The ability of MYC mutants to promote global transcription and serine 2 phosphorylation correlates with their ability to suppress CDK9 SUMOylation and enhance positive transcription elongation factor b (P-TEFb) complex formation. Furthermore, MYC's activity in enhancing global transcription contributes to its activity in promoting cell proliferation and transformation.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Li Li, Xulin Xu, Keyu Lv, Guijuan Zheng, Hao Wang, Shuai Chen, Lang Huang, Yi Liu, Yadong Zhang, Zhaoming Tang, Lili Zhang, Jinyu Wang, Jianlin Qiao, Hongliang Li, Xuanbin Wang, Guangmin Yao, Chao Fang
Summary: Asebogenin exhibits potent antithrombotic effects by inhibiting platelet activation and neutrophil extracellular trap formation, and its mechanism of action is mediated by targeting Syk.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Vipada Kantayos, Jin-Suk Kim, So-Hyeon Baek
Summary: Resveratrol and its derivatives, including piceid, show potential health-related biological activities. Resveratrol production is uncommon in plants, leading to the development of resveratrol-enriched rice (DJ526) for its nutritional and therapeutic value. Elicitation using various elicitors can enhance resveratrol production, with jasmonic acid and MeJA showing strong elicitation effects. These elicitors can also elicit biological activities, such as anti-melanogenic activities, in DJ526 cell suspension.
Article
Biochemistry & Molecular Biology
Daniela Di Marcantonio, Esteban Martinez, Joice S. Kanefsky, Jacklyn M. Huhn, Rashid Gabbasov, Anushk Gupta, John J. Krais, Suraj Peri, YinFei Tan, Tomasz Skorski, Adrienne Dorrance, Ramiro Garzon, Aaron R. Goldman, Hsin-Yao Tang, Neil Johnson, Stephen M. Sykes
Summary: The study reveals that AML relies on ATF3-regulated serine and nucleotide metabolism, with ATF3 inhibition leading to reduced serine synthesis, impediments in carbon incorporation into new purines, and disruption of pyrimidine metabolism.