Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

Metformin alters DNA methylation genome-wide via the H19/SAHH axis

(2016) T Zhong et al.   ONCOGENE

Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

(2016) Karl Bacos et al.   Nature Communications

Genomic Characterization of Metformin Hepatic Response

(2016) Marcelo R. Luizon et al.   PLoS Genetics

Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study

(2015) Panu Rantakokko et al.   Environmental Health

Epigenetic Alterations in Human Liver From Subjects With Type 2 Diabetes in Parallel With Reduced Folate Levels

(2015) Emma Nilsson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study

(2014) Tanja Dujic et al.   DIABETES

Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes

(2014) E. Nilsson et al.   DIABETES

Lipoprotein subclass metabolism in nonalcoholic steatohepatitis

(2014) Ville T. Männistö et al.   JOURNAL OF LIPID RESEARCH

An update on the pharmacogenomics of metformin: progress, problems and potential

(2014) Jennifer N Todd et al.   PHARMACOGENOMICS

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts

(2014) James R Wagner et al.   GENOME BIOLOGY

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

(2013) Dorota Kaminska et al.   DIABETOLOGIA

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function

(2013) Maxim Ivanov et al.   GENOME BIOLOGY

Genetic and epigenetic control of metabolic health

(2013) Robert Wolfgang Schwenk et al.   Molecular Metabolism

Loss of multidrug and toxin extrusion 1 (MATE1) is associated with metformin-induced lactic acidosis

(2012) K Toyama et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3

(2012) L Chen et al.   PHARMACOGENOMICS JOURNAL

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma

(2011) Elke Schaeffeler et al.   Genome Medicine

Metformin and cancer: Doses, mechanisms and the dandelion and hormetic phenomena

(2010) Begoña Martin-Castillo et al.   CELL CYCLE

Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program

(2010) K. A. Jablonski et al.   DIABETES

Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

(2009) K. Zhou et al.   DIABETES

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

(2009) M. L. Becker et al.   DIABETES

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

(2009) Anne T. Nies et al.   HEPATOLOGY

Targeted Disruption of the Multidrug and Toxin Extrusion 1 (Mate1) Gene in Mice Reduces Renal Secretion of Metformin

(2009) M. Tsuda et al.   MOLECULAR PHARMACOLOGY