Protein Modifications with Ubiquitin as Response to Cerebral Ischemia-Reperfusion Injury

USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice

(2017) Jia-Wei Min et al.   JOURNAL OF NEUROCHEMISTRY

rAAV8-733-Mediated Gene Transfer of CHIP/Stub-1 Prevents Hippocampal Neuronal Death in Experimental Brain Ischemia

(2017) Felipe Cabral-Miranda et al.   MOLECULAR THERAPY

The role of SUMOylation in cerebral hypoxia and ischemia

(2017) Myriam Peters et al.   NEUROCHEMISTRY INTERNATIONAL

S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation

(2017) Roshan Kumar et al.   Scientific Reports

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABABReceptors to Lysosomal Degradation

(2016) Khaled Zemoura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trehalose Inhibits Protein Aggregation Caused by Transient Ischemic Insults Through Preservation of Proteasome Activity, Not via Induction of Autophagy

(2016) Ye Li et al.   MOLECULAR NEUROBIOLOGY

Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation

(2016) Masayuki Kaneko et al.   Scientific Reports

A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation

(2015) Joshua D Bernstock et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Systemic Proteasome Inhibition Induces Sustained Post-stroke Neurological Recovery and Neuroprotection via Mechanisms Involving Reversal of Peripheral Immunosuppression and Preservation of Blood–Brain–Barrier Integrity

(2015) Thorsten R. Doeppner et al.   MOLECULAR NEUROBIOLOGY

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity

(2015) Jung Hoon Lee et al.   Scientific Reports

Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates

(2014) H. C. Besche et al.   EMBO JOURNAL

SUMO2/3 is Associated with Ubiquitinated Protein Aggregates in the Mouse Neocortex after Middle Cerebral Artery Occlusion

(2014) Karin Hochrainer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ubiquilin-1 Protects Cells from Oxidative Stress and Ischemic Stroke Caused Tissue Injury in Mice

(2014) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Small Ubiquitin-Like Modifier 3–Modified Proteome Regulated by Brain Ischemia in Novel Small Ubiquitin-Like Modifier Transgenic Mice

(2014) Wei Yang et al.   STROKE

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

(2014) Mingming Zhang et al.   Scientific Reports

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Protein quality control and elimination of protein waste: The role of the ubiquitin–proteasome system

(2013) Ingo Amm et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reactive glia show increased immunoproteasome activity in Alzheimer’s disease

(2013) Marie Orre et al.   BRAIN

SUMO: A Multifaceted Modifier of Chromatin Structure and Function

(2013) Caelin Cubeñas-Potts et al.   DEVELOPMENTAL CELL

Ischemic Postconditioning Protects Neuronal Death Caused by Cerebral Ischemia and Reperfusion via Attenuating Protein Aggregation

(2013) Jianmin Liang et al.   International Journal of Medical Sciences

Negative Regulation of 26S Proteasome Stability via Calpain-mediated Cleavage of Rpn10 Subunit upon Mitochondrial Dysfunction in Neurons

(2013) Qian Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Ubiquitin-Modified Proteome Regulated by Transient Forebrain Ischemia

(2013) Masahiro Iwabuchi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regulation of Acetylation Restores Proteolytic Function of Diseased Myocardium in Mouse and Human

(2013) Ding Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D

(2013) Vivek Gautam et al.   NEUROPHARMACOLOGY

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Excitotoxic stimulation downregulates the ubiquitin–proteasome system through activation of NMDA receptors in cultured hippocampal neurons

(2012) Margarida V. Caldeira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis

(2012) Thorsten R. Doeppner et al.   BRAIN

Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke

(2012) Jenny Lackovic et al.   EXPERIMENTAL NEUROLOGY

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

(2012) Jason Howitt et al.   JOURNAL OF CELL BIOLOGY

Regulation of Feedback between Protein Kinase A and the Proteasome System Worsens Huntington's Disease

(2012) J.-T. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

(2012) Seung Min Shin et al.   NATURE NEUROSCIENCE

Activity-Dependent Growth of New Dendritic Spines Is Regulated by the Proteasome

(2012) Andrew M. Hamilton et al.   NEURON

Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity

(2012) Fabienne Aillet et al.   PLoS One

RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

(2012) C. M. Guzzo et al.   Science Signaling

Reperfusion Rather than Ischemia Drives the Formation of Ubiquitin Aggregates After Middle Cerebral Artery Occlusion

(2012) Karin Hochrainer et al.   STROKE

Enhanced SUMOylation and SENP-1 Protein Levels following Oxygen and Glucose Deprivation in Neurones

(2011) Helena Cimarosti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SUMO2/3 Conjugation is an Endogenous Neuroprotective Mechanism

(2011) Anna Lena Datwyler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cyclin-Dependent Kinase 5 Regulates PSD-95 Ubiquitination in Neurons

(2011) M. J. Bianchetta et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2

(2011) M. P. Lussier et al.   JOURNAL OF NEUROSCIENCE

Analysis of Oxygen/Glucose-Deprivation-Induced Changes in SUMO3 Conjugation Using SILAC-Based Quantitative Proteomics

(2011) Wei Yang et al.   JOURNAL OF PROTEOME RESEARCH

Oxidative Stress-Mediated Regulation of Proteasome Complexes

(2011) Charity T. Aiken et al.   MOLECULAR & CELLULAR PROTEOMICS

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones

(2011) Lynn Bedford et al.   NEUROSCIENCE LETTERS

Elevated Global SUMOylation in Ubc9 Transgenic Mice Protects Their Brains against Focal Cerebral Ischemic Damage

(2011) Yang-ja Lee et al.   PLoS One

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

Autophagy and protein aggregation after brain ischemia

(2010) Chunli Liu et al.   JOURNAL OF NEUROCHEMISTRY

Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPA Receptor Endocytosis and Sorting Pathway

(2010) L. A. Schwarz et al.   JOURNAL OF NEUROSCIENCE

Monoubiquitination of RPN10 Regulates Substrate Recruitment to the Proteasome

(2010) Marta Isasa et al.   MOLECULAR CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury

(2010) Hao Liu et al.   NEUROBIOLOGY OF DISEASE

PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia

(2010) X Kang et al.   ONCOGENE

Degradation of Postsynaptic Scaffold GKAP and Regulation of Dendritic Spine Morphology by the TRIM3 Ubiquitin Ligase in Rat Hippocampal Neurons

(2010) Albert Y. Hung et al.   PLoS One

Regulation of the 26S Proteasome Complex During Oxidative Stress

(2010) X. Wang et al.   Science Signaling

Combination Treatment With VELCADE and Low-Dose Tissue Plasminogen Activator Provides Potent Neuroprotection in Aged Rats After Embolic Focal Ischemia

(2010) Li Zhang et al.   STROKE

Characterization of the brain 26S proteasome and its interacting proteins

(2010) Hwan-Ching Tai   Frontiers in Molecular Neuroscience

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

Regulation of the Proteasome by Neuronal Activity and Calcium/Calmodulin-dependent Protein Kinase II

(2009) Stevan N. Djakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

A novel method for high accuracy sumoylation site prediction from protein sequences

(2008) Jialin Xu et al.   BMC BIOINFORMATICS

Transient Focal Cerebral Ischemia Induces a Dramatic Activation of Small Ubiquitin-Like Modifier Conjugation

(2008) Wei Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ubiquitin Proteasome-Mediated Synaptic Reorganization: A Novel Mechanism Underlying Rapid Ischemic Tolerance

(2008) R. Meller et al.   JOURNAL OF NEUROSCIENCE

The Ubiquitin-Proteasome System Is a Key Component of the SUMO-2/3 Cycle

(2008) Joost Schimmel et al.   MOLECULAR & CELLULAR PROTEOMICS

Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25

(2008) Erik Meulmeester et al.   MOLECULAR CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY