Article
Neurosciences
Zhihong Wu, Changning Xie, Haixia Kuang, Jian Wu, Xiao Chen, Huibao Liu, Tao Liu
Summary: The study showed that oxytocin plays a critical role in attenuating neonatal neural death by facilitating GABAergic transmission, which may help regulate the excitatory-inhibitory balance in local neuronal networks in NHIE patients.
Article
Neurosciences
Hefei Fu, Jiapeng Wang, Jie Wang, Langni Liu, Jianxiong Jiang, Jiukuan Hao
Summary: This study demonstrated that 4R-cembranoid promotes the protective M2 activation and inhibits the damaging M1 activation in microglial cells. The neuroprotective effects of 4R were shown through regulation of microglial activation, with decreased TNF-a release and increased IL-10 release. These findings suggest that 4R could be a promising lead structure for the development of drugs for the treatment of ischemic stroke and other neurodegenerative diseases with an inflammatory component involved.
BRAIN RESEARCH BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Qian Zhang, Jinwei Dai, Zhibing Song, Yuchen Guo, Shanshan Deng, Yongsheng Yu, Tiejun Li, Yuefan Zhang
Summary: The study showed that MQ improved neurobehavior, reduced cerebral infarction areas, altered blood flow, and morphological changes in the cortex and hippocampus in a rat model of brain ischemia-reperfusion injury. Additionally, it decreased neuronal apoptosis and malondialdehyde levels, while increasing superoxide dismutase levels. In vitro studies demonstrated that MQ enhanced cell survival rates and decreased reactive oxygen species levels. Furthermore, protein and mRNA expressions involved in apoptosis were significantly decreased, suggesting a neuroprotective effect of MQ in cerebral ischemia by blocking the p-JNK/Bax pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Nicholas P. DeAdder, Hannah J. Gillam, Brian C. Wilson
Summary: The study showed that H2 and H3 relaxin treatments have a protective effect on cell death caused by oxygen and glucose deprivation, with the effect of H3 relaxin being partially attenuated by L-NIL, and antagonism of RXFP3 affecting the action of H3 relaxin.
Article
Neurosciences
Hyuk Sung Kwon, Jungsoon Ha, Ji Young Kim, Hyun-Hee Park, Eun-Hye Lee, Hojin Choi, Kyu-Yong Lee, Young Joo Lee, Seong-Ho Koh
Summary: The study showed that telmisartan attenuated the activation of the NLRP3 inflammasome by triggering the PI3K pathway, contributing to neuroprotection in neural stem cells.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Feng, Luodan Yang, Xiaohui Ma, Zhihai Huang, Xuemei Zong, Cristiane Teresinha Citadin, Hung Wen Lin, Quanguang Zhang
Summary: The study investigated the effects of photobiomodulation (PBM) on synaptic proteins and astrocyte polarization after stroke. PBM treatment increased synaptic proteins and neuroprotective astrocytic marker, while inhibiting neurotoxic astrocytic marker in stroke-induced rats. In vitro studies also showed that PBM treatment could protect neurons and preserve synaptic proteins during oxygen-glucose deprivation (OGD) exposure. Overall, PBM was effective in inhibiting neurotoxic astrocytic polarization and protecting neurons against stroke injury.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Plant Sciences
Yeqing Wang, Shanshan Zhang, Hailai Ni, Yanjie Zhang, Xiaodong Yan, Yue Gao, Beixuan He, Wenzheng Wang, Chong Liu, Meili Guo
Summary: Nicotiflorin, a flavonoid glycoside from traditional Chinese medicine, has shown promise in treating ischemic stroke. This study found that nicotiflorin can alleviate brain damage, improve neurological deficits, and promote autophagy, which plays a significant role in the protective effect of nicotiflorin against ischemic stroke.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
Ji Young Kim, Mina Hwang, Na-Young Choi, Seong-Ho Koh
Summary: Naloxone exhibits anti-inflammatory and neuroprotective effects in neural stem cells injured by oxygen-glucose deprivation (OGD) by inhibiting NLRP3 inflammasome activation/assembly mediated by the activation of the PI3K signaling pathway.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Andrea Ovcjak, Aijiao Xiao, Ji-Sun Kim, Baofeng Xu, Vivian Szeto, Ekaterina Turlova, Ahmed Abussaud, Nai-hong Chen, Steven P. Miller, Hong-Shuo Sun, Zhong-Ping Feng
Summary: In this study, the effects of RyR antagonist, dantrolene, on hypoxic-ischemic (HI) brain injury were investigated in neonatal mice. It was found that dantrolene administration reduced the infarction volume and morphological damage induced by HI and improved functional recovery. In vitro experiments showed that dantrolene protected neuronal cells from oxygen-glucose deprivation-induced cell death and reduced intracellular calcium levels. These findings suggest that dantrolene exerts neuroprotective effects against neonatal HI brain injury and RyRs may play a role in mediating the ionic imbalance induced by HI, making them a potential target for drug development.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Chemistry, Medicinal
Tae-Hoon Park, Han-Gyul Lee, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Jung-Mi Park, Chang-Nam Ko, Ki-Ho Cho, Seungwon Kwon, Sang-Kwan Moon
Summary: This study investigated the effects of Geopung-Chunghyuldan (GCD) and its component Chunghyuldan (CD) on ischemic brain damage. The results showed that GCD significantly reduced cell death in an in vitro ischemia model, while CD did not show a significant protective effect. In an in vivo ischemia mice model, GCD and CD both reduced the infarct volume, with GCD showing a more significant effect. This suggests that GCD may have a synergistic neuroprotective effect and could be a potential alternative for the prevention and treatment of ischemic stroke.
Article
Pharmacology & Pharmacy
Musadiq A. Bhat, Abolghasem Esmaeili, Elena Neumann, Karthik Balakrishnan, Dietmar Benke
Summary: GABA(B) receptors play a crucial role in controlling neuronal excitability, and their downregulation can lead to excitotoxicity. This study found that preventing the interaction between CHOP and GABA(B) receptors can restore their normal expression and reduce neuronal death.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ziyu Wang, Fenglian Xu, Xueyan Zhao, Yi Zhang, Xi Wang, Zhirui Zhang, Lele Zixin Yang, Joshua Sam Badshah, Baohui Xu, Rong Xie, Weirong Fang
Summary: In this study, exosomes derived from mouse astrocytes were sequenced to investigate the differentially expressed microRNAs following oxygen glucose deprivation/re-oxygenation injury, which mimics ischemic stroke. A total of 176 microRNAs, including known and novel microRNAs, were found to be differentially expressed in astrocyte-derived exosomes. These alterations in microRNAs are associated with a broad range of physiological functions, such as signaling transduction, neuroprotection, and stress responses. Further investigation of these differentially expressed microRNAs in human diseases, especially ischemic stroke, is warranted.
Article
Cell Biology
Olga Kopach, Dmitri A. Rusakov, Sergiy Sylantyev
Summary: The study found that beta-Alanine can protect key physiological functions of brain cells in acute stroke-like conditions, suggesting its potential importance in acute stroke treatment and recovery facilitation.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Zhen-Tao Mo, Jie Zheng, Yu-ling Liao
Summary: The study demonstrated that Icariin may reduce the expression of IL-1 beta, IL-6 and TNF-alpha by inhibiting the IRE1/XBP1s pathway, suggesting a potential therapeutic strategy for brain injury after stroke.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Immunology
Ruili Wang, Lei Li, Baogong Wang
Summary: Poncirin protects cortical neurons from oxygen-glucose deprivation/reoxygenation injury by inhibiting the NOX4/ROS/NLRP3 axis. It alleviates neuronal damage caused by mitochondrial dysfunction, oxidative stress, and inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Ulrich Dirnagl
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Patrick Dupont, Soren Christensen, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Gotz Thomalla, Robin Lemmens
Summary: This study evaluated the ability of quantitative DWI and FLAIR to predict DWI-FLAIR mismatch in ischemic stroke. The results showed that the agreement between quantitative parameters and DWI-FLAIR mismatch was insufficient and there was a moderate correlation between the two quantitative parameters. The interquartile range rDWI SI was found to be associated with excellent functional outcome.
Article
Neurosciences
Stefan Hirschberg, Anton Dvorzhak, Seyed M. A. Rasooli-Nejad, Svilen Angelov, Marieluise Kirchner, Philipp Mertins, Gilla Laettig-Tuennemann, Christoph Harms, Dietmar Schmitz, Rosemarie Grantyn
Summary: The study demonstrated that C-terminal modified EAAT2 enhanced glutamate uptake, facilitated the clearance of glutamate at synapses, and alleviated mHTT-induced movement deficits.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Mayowa O. Owolabi, Amanda G. Thrift, Ajay Mahal, Marie Ishida, Sheila Martins, Walter Johnson, Jeyaraj Pandian, Foad Abd-Allah, Joseph Yaria, Hoang T. Phan, Greg Roth, Seana L. Gall, Richard Beare, Thanh G. Phan, Robert Mikulik, Rufus O. Akinyemi, Bo Norrving, Michael Brainin, Valery L. Feigin
Summary: Stroke is a major global threat to life and disability, particularly in low- and middle-income countries that struggle to address its challenges. This article provides an overview of primary stroke prevention, estimating the cost and identifying deficiencies in guidelines and primary prevention approaches. Pragmatic solutions are offered, emphasizing the role of governments and population-wide strategies. Implementation of primary stroke prevention involves various stakeholders across the lifespan.
LANCET PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Melanie T. C. Kuffner, Stefan P. Koch, Marieluise Kirchner, Susanne Mueller, Janet Lips, Jeehye An, Philipp Mertins, Ulrich Dirnagl, Matthias Endres, Philipp Boehm-Sturm, Christoph Harms, Christian J. Hoffmann
Summary: This study investigates the effects of paracrine IL-6 on cerebral remodeling in early stages after asymptomatic carotid artery occlusion, aiming to identify new treatment targets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Regina von Rennenberg, Thomas Liman, Christian H. Nolte, Alexander H. Nave, Jan F. Scheitz, Sandra Duezel, Vera Regitz-Zagrosek, Denis Gerstorf, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Matthias Endres
Summary: There is evidence of an association between levels of high-sensitivity cardiac troponin T (hs-cTnT) and cognitive decline in older men, as measured by the Digit Symbol Substitution Test (DSST). This association remained significant even after adjusting for age, sex, education, and cardiovascular risk factors. However, there was no significant association between hs-cTnT and different cognitive domains at baseline.
Article
Clinical Neurology
Regina von Rennenberg, Juliane Herm, Thomas Krause, Simon Hellwig, Helena Stengl, Jan F. Scheitz, Thomas Elgeti, Sebastian N. Nagel, Matthias Endres, Karl Georg Haeusler, Christian H. Nolte
Summary: This study found that elevated cardiac biomarkers, such as high-sensitivity cardiac troponin T (hs-cTnT) and brain natriuretic peptide (BNP), in acute stroke patients are strongly associated with pathological findings on cardiac magnetic resonance imaging (CMR). The elevation of these biomarkers may help identify patients who require a more comprehensive cardiology work-up.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Thomas Ihl, Michael Ahmadi, Inga Laumeier, Maureen Steinicke, Caroline Ferse, Philipp Klyscz, Matthias Endres, Sidsel Hastrup, Holger Poppert, Frederick Palm, Farid Kandil, Joachim E. Weber, Paul Von Weitzel-Mudersbach, Martin L. J. Wimmer, Heinrich J. Audebert
Summary: The INSPiRE-TMS trial investigated the effects of a multicomponent support program in patients with nondisabling stroke or transient ischemic attack, showing that the intensified care group had slightly better results for physical fitness and modified Rankin Scale after 1 year, but none of the other patient-centered outcomes were significantly improved.
Article
Clinical Neurology
Ewgenia Barow, Fanny Quandt, Bastian Cheng, Mathias Gelderblom, Maerit Jensen, Alina Koenigsberg, Florent Boutitie, Norbert Nighoghossian, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Vincent Thijs, Robin Lemmens, Keith W. Muir, Salvador Pedraza, Claus Z. Simonsen, Christian Gerloff, Goetz Thomalla
Summary: Higher white blood cell count is associated with poor functional outcome in acute ischemic stroke, independent of treatment with alteplase. Elevated white blood cell count is also associated with increased risk of hemorrhagic transformation and larger stroke volume.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Luis P. Kuschel, Juergen Hench, Stephan Frank, Ivana Bratic Hench, Elodie Girard, Maud Blanluet, Julien Masliah-Planchon, Martin Misch, Julia Onken, Marcus Czabanka, Dongsheng Yuan, Soeren Lukassen, Philipp Karau, Naveed Ishaque, Elisabeth G. Hain, Frank Heppner, Ahmed Idbaih, Nikolaus Behr, Christoph Harms, David Capper, Philipp Euskirchen
Summary: DNA methylation-based classification is important for the diagnosis of brain tumors. Nanopore sequencing provides a fast and cost-effective method for this classification.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Hematology
Christopher M. Arends, Thomas G. Liman, Paulina M. Strzelecka, Anna Kufner, Pelle Loewe, Shufan Huo, Catarina M. Stein, Sophie K. Piper, Marlon Tilgner, Pia S. Sperber, Savvina Dimitriou, Peter U. Heuschmann, Raphael Hablesreiter, Christoph Harms, Lars Bullinger, Joachim E. Weber, Matthias Endres, Frederik Damm
Summary: Clonal hematopoiesis (CH) is common among older people and is associated with an increased risk of atherosclerosis, inflammation, and shorter overall survival. This study investigated CH in patients with first-ever ischemic stroke and found that CH is associated with an increased risk of recurrent vascular events and death.
Article
Endocrinology & Metabolism
Christian J. Hoffmann, Melanie T. C. Kuffner, Leif Koschuetzke, Stephanie Lorenz, Janet Lips, Philipp Boehm-Sturm, Susanne Mueller, Stefan P. Koch, Jeehye An, Lucius S. Fekonja, Polina Bugaeva, Andre Rex, Gisela Laettig Tuennemann, Matthias Endres, Christoph Harms
Summary: Paracrine cerebral Interleukin 6 (Il6) plays a role in stroke recovery, but systemic Il6 elevation may worsen outcome. Lithium modulates Il6 responses and improves stroke outcome, but has adverse effects. Zincfinger protein 580 (Zfp580) mediates the effects of lithium on Il6 signaling without adverse effects, improving cognitive and motor function. Inactivation of Zfp580 has positive effects on multiple key mechanisms, making it a potentially more specific and effective treatment target for stroke recovery than lithium. Zfp580 inhibitors must be developed to fully assess its potential.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Jeehye An, Leo Wendt, Georg Wiese, Tom Herold, Norman Rzepka, Susanne Mueller, Stefan Paul Koch, Christian J. Hoffmann, Christoph Harms, Philipp Boehm-Sturm
Summary: This paper presents a fully automated method for segmenting ischemic stroke lesions in mice using MRI. The method utilizes an end-to-end deep learning approach, requiring minimal preprocessing and working directly on raw MRI scans. The results show high agreement with manual segmentation, surpassing the consistency between human raters reported in previous studies.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Stefan Hirschberg, Fatemeh Ghazaani, Ghada Ben Amor, Markus Pydde, Alexander Nagel, Saveria Germani, Lara Monica, Anja Schloer, Hannes Bauer, Jane Hornung, Michael Voetz, Yamen Dwai, Benjamin Scheer, Frauke Ringel, Omar Kamal-Eddin, Christoph Harms, Jonas Fuener, Lorenz Adrian, Axel Pruss, Kai Schulze-Forster, Katja Hanack, Julian Kamhieh-Milz
Summary: This study developed a cost-efficient and scalable human cell line for the production of immunogenic SARS-CoV-2 virus-like particles (VLPs). The modular design of the VLP production platform allows for rapid adaptation to new variants. The generated VLPs contained all structural proteins, exhibited specific reactivity with serum from naturally infected individuals, and demonstrated stability at low temperatures. Mice immunized with these VLPs produced neutralizing antibodies against the SARS-CoV-2 spike protein. The findings highlight the efficient, scalable, and adaptable nature of this production method, which holds therapeutic potential.
