期刊
TOXICON
卷 60, 期 3, 页码 254-264出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2012.04.336
关键词
Pain; Venom; TRPV1; ASIC; Multivalent toxin; Multimeric toxin
资金
- Ruth Kirschstein predoctoral fellowship [F31NS065597]
- NIH/NINDS [R01NS065071]
Venoms often target vital processes to cause paralysis or death, but many types of venom also elicit notoriously intense pain. While these pain-producing effects can result as a byproduct of generalized tissue trauma, there are now multiple examples of venom-derived toxins that target somatosensory nerve terminals in order to activate nociceptive (pain-sensing) neural pathways. Intriguingly, investigation of the venom components that are responsible for evoking pain has revealed novel roles and/or configurations of well-studied toxin motifs. This review serves to highlight pain-producing toxins that target the capsaicin receptor, TRPV1, or members of the acid-sensing ion channel family, and to discuss the utility of venom-derived multivalent and multimeric complexes. (C) 2012 Elsevier Ltd. All rights reserved.
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