Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis

HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription

(2016) Ophélie Cosnefroy et al.   Retrovirology

Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

(2016) Chuang Liu et al.   Nature Communications

A Novel Entry/Uncoating Assay Reveals the Presence of at Least Two Species of Viral Capsids During Synchronized HIV-1 Infection

(2016) Claire Da Silva Santos et al.   PLoS Pathogens

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

(2016) Ashwanth C. Francis et al.   PLoS Pathogens

KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection

(2016) Adarsh Dharan et al.   PLoS Pathogens

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer

(2015) Suyoun Chung et al.   Oncotarget

HIV-1 uncoating: connection to nuclear entry and regulation by host proteins

(2014) Zandrea Ambrose et al.   VIROLOGY

A model for cofactor use during HIV-1 reverse transcription and nuclear entry

(2014) Laura Hilditch et al.   Current Opinion in Virology

A Carboxy-Terminally Truncated Human CPSF6 Lacking Residues Encoded by Exon 6 Inhibits HIV-1 cDNA Synthesis and Promotes Capsid Disassembly

(2013) T. Hori et al.   JOURNAL OF VIROLOGY

Human Cytosolic Extracts Stabilize the HIV-1 Core

(2013) T. Fricke et al.   JOURNAL OF VIROLOGY

Expansion of Activated Memory CD4+ T Cells Affects Infectivity of CCR5-Tropic HIV-1 in Humanized NOD/SCID/JAK3null Mice

(2013) Kazutaka Terahara et al.   PLoS One

HIV-1-associated PKA acts as a cofactor for genome reverse transcription

(2013) Charline Giroud et al.   Retrovirology

The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6

(2013) Thomas Fricke et al.   Retrovirology

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

(2013) Alberto De Iaco et al.   Retrovirology

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Inhibition of Reverse Transcriptase Activity Increases Stability of the HIV-1 Core

(2012) Y. Yang et al.   JOURNAL OF VIROLOGY

Human Nucleoporins Promote HIV-1 Docking at the Nuclear Pore, Nuclear Import and Integration

(2012) Francesca Di Nunzio et al.   PLoS One

Multiple roles of the capsid protein in the early steps of HIV-1 infection

(2012) Ariberto Fassati   VIRUS RESEARCH

A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development

(2011) Y. Le Page et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases

(2011) Hirotaka Yoshida et al.   JOURNAL OF NEUROCHEMISTRY

RING Domain Mutations Uncouple TRIM5  Restriction of HIV-1 from Inhibition of Reverse Transcription and Acceleration of Uncoating

(2011) A. Roa et al.   JOURNAL OF VIROLOGY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway

(2011) I. Nakano et al.   NEURO-ONCOLOGY

Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription

(2011) A. E. Hulme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability

(2011) Jiyang Jiang et al.   VIROLOGY

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

(2011) Torsten Schaller et al.   PLoS Pathogens

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter­Hexamer Interfaces

(2011) Gongpu Zhao et al.   PLoS Pathogens

Uncoating of Human Immunodeficiency Virus Type 1 Requires Prolyl Isomerase Pin1

(2010) Shogo Misumi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A B-Box 2 Surface Patch Important for TRIM5  Self-Association, Capsid Binding Avidity, and Retrovirus Restriction

(2009) F. Diaz-Griffero et al.   JOURNAL OF VIROLOGY

Separation and detection of large phosphoproteins using Phos-tag SDS-PAGE

(2009) Eiji Kinoshita et al.   Nature Protocols

Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

(2009) Uppoor G. Bhat et al.   PLoS One

Selective Transmission of R5 HIV-1 over X4 HIV-1 at the Dendritic Cell–T Cell Infectious Synapse Is Determined by the T Cell Activation State

(2009) Takuya Yamamoto et al.   PLoS Pathogens

Overexpressed NF- B-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells

(2008) Y. Saitoh et al.   BLOOD

Transportin-SR2 Imports HIV into the Nucleus

(2008) Frauke Christ et al.   CURRENT BIOLOGY

VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability

(2008) Sonia Brun et al.   Retrovirology