p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate

p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis

(2015) Maria Rosaria Mollo et al.   EXPERIMENTAL DERMATOLOGY

Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate

(2015) Huan Liu et al.   HUMAN MOLECULAR GENETICS

TGFβ3 Regulates Periderm Removal Through ΔNp63 in the Developing Palate

(2015) Lihua Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

p63 transcriptionally regulates the expression of matrix metallopeptidase 13

(2015) Ivana Celardo et al.   Oncotarget

Deciphering TGF-β3 function in medial edge epithelium specification and fusion during mouse secondary palate development

(2014) Jiu-Zhen Jin et al.   DEVELOPMENTAL DYNAMICS

Periderm prevents pathological epithelial adhesions during embryogenesis

(2014) Rebecca J. Richardson et al.   JOURNAL OF CLINICAL INVESTIGATION

Dominant Mutations in GRHL3 Cause Van der Woude Syndrome and Disrupt Oral Periderm Development

(2013) Myriam Peyrard-Janvid et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Smad4-Irf6 genetic interaction and TGF -mediated IRF6 signaling cascade are crucial for palatal fusion in mice

(2013) J.-i. Iwata et al.   DEVELOPMENT

Genomic Profiling of a Human Organotypic Model of AEC Syndrome Reveals ZNF750 as an Essential Downstream Target of Mutant TP63

(2012) Brian J. Zarnegar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ZNF750 Is a p63 Target Gene that Induces KLF4 to Drive Terminal Epidermal Differentiation

(2012) George L. Sen et al.   DEVELOPMENTAL CELL

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

(2012) Giustina Ferone et al.   EMBO Molecular Medicine

Periderm cells covering palatal shelves have tight junctions and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis

(2012) Midori Yoshida et al.   GENES TO CELLS

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome

(2012) Giustina Ferone et al.   HUMAN MOLECULAR GENETICS

Ctip2 is a dynamic regulator of epidermal proliferation and differentiation by integrating EGFR and Notch signaling

(2012) L.-j. Zhang et al.   JOURNAL OF CELL SCIENCE

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

(2012) Simon S. McDade et al.   NUCLEIC ACIDS RESEARCH

Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development

(2011) J. O. Bush et al.   DEVELOPMENT

Cleft lip and palate: understanding genetic and environmental influences

(2011) Michael J. Dixon et al.   NATURE REVIEWS GENETICS

Mutations in PVRL4, Encoding Cell Adhesion Molecule Nectin-4, Cause Ectodermal Dysplasia-Syndactyly Syndrome

(2010) Francesco Brancati et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Filtering error from SOLiD Output

(2010) Ariella Sasson et al.   BIOINFORMATICS

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Genome-Wide Profiling of p63 DNA–Binding Sites Identifies an Element that Regulates Gene Expression during Limb Development in the 7q21 SHFM1 Locus

(2010) Evelyn N. Kouwenhoven et al.   PLoS Genetics

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence

(2009) Rebecca J. Richardson et al.   HUMAN MOLECULAR GENETICS

Cleft lip and palate

(2009) Peter A Mossey et al.   LANCET

An Active Role of the ΔN Isoform of p63 in Regulating Basal Keratin Genes K5 and K14 and Directing Epidermal Cell Fate

(2009) Rose-Anne Romano et al.   PLoS One

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

TFAP2A Mutations Result in Branchio-Oculo-Facial Syndrome

(2008) Jeff M. Milunsky et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling

(2008) Helen A. Thomason et al.   DEVELOPMENTAL BIOLOGY

Direct targets of the TRP63 transcription factor revealed by a combination of gene expression profiling and reverse engineering

(2008) G. Della Gatta et al.   GENOME RESEARCH

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY