Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

Involvement of translesion synthesis DNA polymerases in DNA interstrand crosslink repair

(2016) Upasana Roy et al.   DNA REPAIR

DNA polymerase θ (POLQ), double-strand break repair, and cancer

(2016) Richard D. Wood et al.   DNA REPAIR

Essential Roles for Polymerase θ-Mediated End Joining in the Repair of Chromosome Breaks

(2016) David W. Wyatt et al.   MOLECULAR CELL

Multiple mechanisms contribute to double-strand break repair at rereplication forks inDrosophilafollicle cells

(2016) Jessica L. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining

(2016) Robin van Schendel et al.   PLoS Genetics

Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

(2016) Tatiana Kent et al.   eLife

Linking DNA polymerase theta structure and function in health and disease

(2015) Kelly Beagan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistance

(2015) Brittany Haynes et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

(2015) Raphael Ceccaldi et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

(2015) Joseph A. Newman et al.   STRUCTURE

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ

(2015) Tatiana Kent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

(2015) Sean M. Howard et al.   PLoS Genetics

Mechanism and regulation of incisions during DNA interstrand cross-link repair

(2014) Jieqiong Zhang et al.   DNA REPAIR

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

(2014) S. F. Roerink et al.   GENOME RESEARCH

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

(2014) Wouter Koole et al.   Nature Communications

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population

(2013) Wen-Qing Li et al.   CARCINOGENESIS

Targeted engineering of the Drosophila genome

(2013) Juan Huang et al.   FLY

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase POLQ and cellular defense against DNA damage

(2012) Matthew J. Yousefzadeh et al.   DNA REPAIR

DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients

(2012) C Allera-Moreau et al.   Oncogenesis

Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases

(2011) The Vinh Ho et al.   NUCLEIC ACIDS RESEARCH

Novel Enzymatic Function of DNA Polymerase ν in Translesion DNA Synthesis Past Major Groove DNA−Peptide and DNA−DNA Cross-Links

(2010) Kinrin Yamanaka et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Synthesis and Molecular Modeling of a Nitrogen Mustard DNA Interstrand Crosslink

(2010) Angelo Guainazzi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

(2010) Amy Marie Yu et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase   up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

(2010) F. Lemee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila

(2010) Sze Ham Chan et al.   PLoS Genetics

DNA interstrand crosslink repair in mammalian cells: step by step

(2009) Parameswary A Muniandy et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

DNA Polymerase POLN Participates in Cross-Link Repair and Homologous Recombination

(2009) G.-L. Moldovan et al.   MOLECULAR AND CELLULAR BIOLOGY

A ‘DNA replication’ signature of progression and negative outcome in colorectal cancer

(2009) M-J Pillaire et al.   ONCOGENE

Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways

(2008) Diego M. Muzzini et al.   DNA REPAIR