Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

Context Specificity of Stress-activated Mitogen-activated Protein (MAP) Kinase Signaling: The Story as Told byCaenorhabditis elegans

(2016) Matthew G. Andrusiak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione S-transferase mediates an ageing response to mitochondrial dysfunction

(2016) Beverley M. Dancy et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans

(2016) Erin Munkácsy et al.   PLoS Genetics

The glyoxylate shunt is essential for desiccation tolerance in C. elegans and budding yeast

(2016) Cihan Erkut et al.   eLife

Tissue-specific autophagy responses to aging and stress in C. elegans

(2015) Hannah C. Chapin et al.   Aging-US

Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury

(2015) Daniel M. Kaufman et al.   CURRENT BIOLOGY

The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans

(2015) Yaguang Ren et al.   EXPERIMENTAL GERONTOLOGY

Global Proteomics Analysis of the Response to Starvation inC. elegans

(2015) Mark Larance et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Tether mutations that restore function and suppress pleiotropic phenotypes of theC. elegans isp-1(qm150)Rieske iron–sulfur protein

(2015) Gholamali Jafari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

(2015) S. F. Leiser et al.   SCIENCE

Mitochondrial dysfunction and longevity in animals: Untangling the knot

(2015) Y. Wang et al.   SCIENCE

Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans

(2015) Daniel J. Pagano et al.   PLoS Genetics

The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans

(2014) Callista Yee et al.   CELL

Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

(2014) Orane Visvikis et al.   IMMUNITY

Lipid Droplet Protein LID-1 Mediates ATGL-1-Dependent Lipolysis during Fasting in Caenorhabditis elegans

(2014) J. H. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity inCaenorhabditis elegans

(2014) Ara B. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation

(2014) Shanshan Pang et al.   Nature Communications

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

(2013) Eyleen J. O’Rourke et al.   NATURE CELL BIOLOGY

The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway

(2013) M. Rauthan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

(2013) Masaharu Uno et al.   Cell Reports

Forgetting in C. elegans Is Accelerated by Neuronal Communication via the TIR-1/JNK-1 Pathway

(2013) Akitoshi Inoue et al.   Cell Reports

TARGETED, LCMS-BASED METABOLOMICS FOR QUANTITATIVE MEASUREMENT OF NAD + METABOLITES

(2013) Samuel AJ Trammell et al.   Computational and Structural Biotechnology Journal

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

(2012) Michael J. Steinbaugh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans

(2012) Alfonso Schiavi et al.   EXPERIMENTAL GERONTOLOGY

Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

(2012) Reagan M. Jarvis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Improved Mos1-mediated transgenesis in C. elegans

(2012) Christian Frøkjær-Jensen et al.   NATURE METHODS

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

(2011) Scott F. Leiser et al.   AGING CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans

(2011) Patricia Back et al.   FREE RADICAL BIOLOGY AND MEDICINE

Making heads or tails of phospholipids in mitochondria

(2011) Christof Osman et al.   JOURNAL OF CELL BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The Homeobox Protein CEH-23 Mediates Prolonged Longevity in Response to Impaired Mitochondrial Electron Transport Chain in C. elegans

(2011) Ludivine Walter et al.   PLOS BIOLOGY

Ce-Duox1/BLI-3 Generated Reactive Oxygen Species Trigger Protective SKN-1 Activity via p38 MAPK Signaling during Infection in C. elegans

(2011) Ransome van der Hoeven et al.   PLoS Pathogens

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial dysfunction in Caenorhabditis elegans causes metabolic restructuring, but this is not linked to longevity

(2010) Steven Zuryn et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress

(2009) Natascia Ventura et al.   AGING CELL

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine

(2009) Robert Hanczko et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

(2009) David Cristina et al.   PLoS Genetics

Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing

(2008) Yueming Qian et al.   BIOCHEMICAL JOURNAL

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

(2008) Erica D Smith et al.   BMC DEVELOPMENTAL BIOLOGY

A 13C Isotope Labeling Strategy Reveals the Influence of Insulin Signaling on Lipogenesis in C. elegans

(2008) Carissa L. Perez et al.   Cell Metabolism

A novel function of peroxiredoxin 1 (Prx-1) in apoptosis signal-regulating kinase 1 (ASK1)-mediated signaling pathway

(2008) So Yong Kim et al.   FEBS LETTERS

Complex I Function Is Defective in Complex IV-deficientCaenorhabditis elegans

(2008) Wichit Suthammarak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS