Article
Biochemistry & Molecular Biology
Woodys Lenga Ma Bonda, Marion Lavergne, Virginie Vasseur, Lucie Brisson, Sebastien Roger, Antoine Legras, Antoine Guillon, Serge Guyetant, Pieter S. Hiemstra, Mustapha Si-Tahar, Sophie Iochmann, Pascale Reverdiau
Summary: KLK5 has been identified as a crucial protease in extracellular matrix remodeling and bronchial epithelial repair after injury. It promotes epithelial-to-mesenchymal transition (EMT) and cell migration by activating the mitogen-activated protein kinase signaling pathway, while also delaying wound healing repair.
Article
Oncology
Juliana B. Candido, Oscar Maiques, Melanie Boxberg, Verena Kast, Eleonora Peerani, Elena Tomas-Bort, Wilko Weichert, Amiram Sananes, Niv Papo, Viktor Magdolen, Victoria Sanz-Moreno, Daniela Loessner
Summary: Kallikrein-related peptidases are upregulated in pancreatic cancer and associated with poor prognosis. Inhibiting KLK may be a potential therapeutic strategy for precision medicine.
Article
Biochemistry & Molecular Biology
Hayet Bouzid, Feryel Soualmia, Katerina Oikonomopoulou, Antoninus Soosaipillai, Francine Walker, Khaoula Louati, Rea Lo Dico, Marc Pocard, Chahrazade El Amri, Natalia A. Ignatenko, Dalila Darmoul
Summary: KLK6 overexpression in colon cancer is associated with poor prognosis and aggressive behavior. KLK6 activates PAR2, leading to calcium flux and ERK1/2 phosphorylation, promoting tumor formation and invasion. Furthermore, KLK6 abnormal expression can be used to differentiate between malignant and benign ascites.
Article
Medicine, Research & Experimental
Dong Zhou, Yanping He, Hengping Li, Weidong Huang
Summary: The study investigated the impact of KLK6 on the proliferation, migration, and invasion of gastric cancer cells, finding that KLK6 inhibition could suppress cell proliferation, migration, and invasion by inhibiting EMT.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Natalia Gruba, Patrycja Rachubik, Agnieszka Piwkowska, Adam Lesner
Summary: This study quantitatively determined the activity of KLK13 in the urine of bladder cancer patients using specific fluorogenic substrates, confirming the presence of KLK13 through immunoenzymatic analyses. The results showed that proteolytically active KLK13 was present in the urine of patients with G2 and G3 grade BC, but not in those with G1 grade BC.
Review
Biochemistry & Molecular Biology
Abi S. Ghifari, Monika W. Murcha
Summary: Mitochondrial function relies on the homeostasis and quality control of their proteome, which includes the components of the oxidative phosphorylation pathway. The subunits of oxidative phosphorylation are prone to oxidative damage, misfolding, and aggregation due to their exposure to reactive oxygen species. Multiple protein degradation pathways are involved in maintaining the activity and homeostasis of oxidative phosphorylation components in plant mitochondria, including proteomic turnover and modular degradation.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Yuta Chiba, Keigo Yoshizaki, Hiroshi Sato, Tomoko Ikeuchi, Craig Rhodes, Mitsuki Chiba, Kan Saito, Takashi Nakamura, Tsutomu Iwamoto, Aya Yamada, Yoshihiko Yamada, Satoshi Fukumoto
Summary: This study found that Gpr115 plays an important role in enamel formation and its deficiency may lead to enamel hypomineralization. Additionally, Gpr111 is also involved in tooth development and its deficiency results in enamel hypomineralization. Both Gpr111 and Gpr115 suppress the mineralization of enamel through regulating extracellular pH and the expression of proteolytic enzymes.
Article
Multidisciplinary Sciences
Shwan Majid Ahmad, Basima Sadq Ahmed, Karzan Ghafur Khidhir, Heshu Sulaiman Rahman
Summary: KLK10 mRNA expression is significantly decreased in pediatric ALL patients and further reduced after receiving chemotherapy for a period of time. Additionally, KLK10 mRNA expression shows high efficiency in discriminating ALL patients from normal counterparts.
Article
Oncology
Weiwei Gong, Caixia Zhu, Yueyang Liu, Alexander Muckenhuber, Holger Bronger, Andreas Scorilas, Marion Kiechle, Julia Dorn, Viktor Magdolen, Tobias Dreyer
Summary: Among TNBC patients, miR-378 and KLK4 mRNA expression levels were found to be independent of each other, with miR-378 and KLK4+miR-378 expression serving as unfavorable prognostic markers.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Farouq Heidar Barido, Sung Ki Lee
Summary: The study found that postmortem tenderization of spent hen meat was significantly improved by AMP treatment, mainly through the synergistic upregulation of cathepsin-B and caspase-3 enzymes, leading to increased myofibril fragmentation and structural alteration.
Article
Oncology
Ryusuke Sumiya, Kazuhiko Yamada, Teruki Hagiwara, Satoshi Nagasaka, Hideki Miyazaki, Toru Igari, Yuki I. Kawamura
Summary: This study investigated the relationship between Klk13 expression and clinicopathological features of lung squamous cell carcinoma (LSCC). Immunohistochemical staining revealed that 70 out of 94 LSCC samples showed no Klk13 expression, while the remaining 24 samples exhibited ectopic expression. Klk13 expression was positively associated with E-cadherin expression, indicating a potential protective role in lymphatic vessel invasion of LSCC.
MOLECULAR AND CLINICAL ONCOLOGY
(2023)
Article
Biology
Tsuyoshi Morita, Ken'ichiro Hayashi
Summary: This study reveals that Arp5 acts as an inhibitory regulator of MyoD and MyoG in skeletal muscle differentiation. Arp5 binds to the CR region of MyoD and MyoG, interfering with their epigenetic functions and suppressing myogenic gene expression. Arp5 expression is elevated in rhabdomyosarcoma cells, contributing to dysregulation of the MRFs and potentially promoting tumorigenic properties. Depletion of Arp5 partially restores myogenic properties in RMS.
Correction
Mathematics, Applied
Halit Orhan, Nanjundan Magesh, Chinnasamy Abirami
Summary: The purpose of this note is to correct some typos in our published article in [1].
Article
Anatomy & Morphology
Pamela Ehrenfeld, Carlos D. Figueroa, Luis Molina, Tania Koning, Myriam Velasco, Felipe A. Bustamante-Barrientos, Alexander Ortloff
Summary: Apocrine glands in the dog's skin are important structures and can be affected by various tumors. This study focuses on the distribution of specific enzymes in these glands and their potential role in diagnosing histopathological conditions. The findings provide new insights into the understanding of these glands in dogs and can contribute to better diagnostic methods.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2023)
Article
Neurosciences
Pauline Burkhardt, Verena Mueller, Hartmut Meister, Anna Weglage, Ruth Lang-Roth, Martin Walger, Pascale Sandmann
Summary: This study investigates the impact of age on cognitive functions and cortical speech processing in cochlear implant (CI) users. The results show that CI users have impaired speech processing at both sensory and semantic integration stages, with age having an impact on cognitive functions and ERPs in both CI users and normal-hearing listeners.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Infectious Diseases
Takamitsu Ohnishi, Shinichi Watanabe, Tetsuya Matsumoto, Hiroshi Yotsuyanagi, Junko Sato, Intestu Kobayashi, Shin Iinuma, Takashi Nagayama, Shuichiro Shibuya, Natsuki Ogawa, Ken Iozumi, Yasuyuki Nakajima, Yukiko Kurikawa, Motoko Kobayashi, Koma Matsuo, Hideyuki Ishikawa, Tadamichi Shimizu, Kiyohiro Tsutsui, Tatsuyoshi Kawamura, Ryuhei Okuyama, Mariko Seishima, Yoichi Akita, Chikatoshi Kasugai, Katsuaki Yano, Yasuhiko Tamada, Kimihiko Mizutani, Kenji Kabashima, Nanako Yamada, Masami Ikeda
Summary: The present study compared trends in antimicrobial resistance patterns in pathogens isolated from skin and soft-tissue infections (SSTIs) in Japan with those of a nationwide survey conducted in 2013. The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) did not differ significantly between the present study and the 2013 survey. However, the prevalence of methicillin-resistant coagulase-negative staphylococci (MRCNS) was higher in the present study compared to the 2013 survey. The susceptibility profiles of MRSA and MRCNS to various antibiotics were not significantly different between the two surveys. Continuous monitoring is important for guiding the appropriate treatment of SSTIs.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Letter
Dermatology
Takayoshi Komatsu-Fujii, Corrine Sison de Jesus, Takashi Nomura, Kenji Kabashima
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Toshiaki Kogame, Satoru Yonekura, Paola Lovato, Masahiro Hirata, Riko Takimoto-ito, Tomoya Takegami, Takayoshi Komatsu-Fujii, Naotomo Kambe, Takashi Nomura, Mads A. Ropke, Kenji Kabashima
Summary: Despite the limited sample size and low frequency of skin ILCs in this study, the data suggest that ICOS+ ILCs express IL-13Ra1 and that the density of ICOS+ ILCs decreases after four weeks of tralokinumab treatment.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Yuki Honda Keith, Atsushi Otsuka, Toshiaki Kogame, Hiroyuki Ito, Shunya Usui, Masakazu Fujimoto, Keita Jinnouchi, Masahiro Hirata, Kazumitsu Sugiura, Kenji Kabashima
JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Marina Ueda, Toshiaki Kogame, Gyohei Egawa, Naotomo Kambe, Kenji Kabashima
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Hidehisa Saeki, Masashi Akiyama, Masatoshi Abe, Atsuyuki Igarashi, Shinichi Imafuku, Yukihiro Ohya, Norito Katoh, Hideto Kameda, Kenji Kabashima, Yuichiro Tsunemi, Michihiro Hide, Mamitaro Ohtsuki
Summary: This guidance provides information on the use of oral JAK inhibitors for the treatment of atopic dermatitis. It explains the role of oral JAK inhibitors in inhibiting the signal transduction of cytokines involved in the pathogenesis of atopic dermatitis. It also highlights the authorized oral JAK inhibitors for atopic dermatitis in Japan and emphasizes the importance of considering disease factors, treatment factors, and patient backgrounds in the selection of treatment options.
JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
R. Bissonnette, L. F. Eichenfield, E. Simpson, D. Thaci, K. Kabashima, J. P. Thyssen, E. Guttman-Yassky, F. P. Nunes, M. Gamalo, F. Ahmad, M. Kuligowski, K. Sun, C. Pipper, A. W. Christensen, P. D'Angelo, M. Milutinovic, A. Guettner, J. I. Silverberg
Summary: Despite the lack of guidelines for analyzing clinical trial data in atopic dermatitis (AD), using the estimand framework can help standardize the analysis and incorporate intercurrent events. Intercurrent events, such as rescue therapy and sleep deprivation, frequently occur in AD trials and their inconsistent handling limits result interpretation. Applying the estimand framework, as guided by the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH), can improve AD trial design and analysis by providing more reflective and informative results for clinicians to make treatment selection.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Emma Guttman-Yassky, Eric L. Simpson, Kristian Reich, Kenji Kabashima, Ken Igawa, Tetsuya Suzuki, Hirotaka Mano, Takeshi Matsui, Ehsanollah Esfandiari, Masutaka Furue
Summary: This study evaluated the efficacy and safety of the anti-OX40 antibody rocatinlimab in patients with moderate-to-severe atopic dermatitis. The results showed significant reductions in EASI score at week 16 in patients receiving rocatinlimab compared to placebo. The treatment led to progressive improvements in atopic dermatitis, which were maintained in most patients after treatment discontinuation, and it was well tolerated.
Article
Dermatology
Amy S. Paller, Jonathan I. Silverberg, Michael J. Cork, Emma Guttman-Yassky, Benjamin Lockshin, Alan D. Irvine, Moon Bum Kim, Kenji Kabashima, Zhen Chen, Yufang Lu, Ashish Bansal, Ana B. Rossi, Arsalan Shabbir
Summary: This study assessed the efficacy and safety of dupilumab in patients with severe erythrodermic atopic dermatitis (AD). The results showed that dupilumab significantly improved AD signs and symptoms, including affected body surface area, Eczema Area and Severity Index (EASI) score, and Pruritus Numerical Rating Scale (PP-NRS) score. The treatment also led to reductions in serum biomarker levels.
Letter
Dermatology
Satoshi Nakamizo, Teruasa Murata, Yoshihiro Ishida, Satomi Aoki, Takashi Sasaki, Akiharu Kubo, Kenji Kabashima
JOURNAL OF DERMATOLOGY
(2023)
Article
Pathology
Masakazu Fujimoto, Toshiya Miyake, Yo Kaku, Masahiro Hirata, Kenji Kabashima, Hironori Haga
Summary: This study aimed to resolve the ongoing debate on whether lymphocytic thrombophilic arteritis (LTA) is a separate disease or a type of polyarteritis nodosa (PAN). Immunohistochemistry analysis of skin biopsies from five LTA patients revealed that the majority of infiltrating cells were myelomonocytic cells rather than lymphocytes. Based on these findings, PAN was considered a more appropriate diagnosis for the five cases. Further investigation is needed to determine if histiocytoid PAN with immature myeloid cells is the same disease as conventional PAN with mature neutrophils.
Article
Dermatology
Kenji Kabashima, Takayo Matsumura, Hiroshi Komazaki, Makoto Kawashima
Summary: This study investigated the impact of nemolizumab on the quality of life in patients with atopic dermatitis. The results showed that nemolizumab treatment improved sleep quality, interpersonal relationships, and work activities.
DERMATOLOGY AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Azusa Saika, Prabha Tiwari, Takahiro Nagatake, Eri Node, Koji Hosomi, Tetsuya Honda, Kenji Kabashima, Jun Kunisawa
Summary: Mead acid can suppress retinol-induced irritant contact dermatitis and prevent keratinocyte hyperproliferation and the expression of neutrophil chemoattractants through the PPAR-alpha pathway.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Immunology
Toshiaki Kogame, Gyohei Egawa, Kenji Kabashima
Summary: Recent studies have shown that Janus kinase (JAK) plays a crucial role in signal transduction for inflammatory diseases like atopic dermatitis (AD). Clinical trials using JAK inhibitors and biologic reagents have been successful in treating AD, indicating the efficacy of molecular-based therapies. However, there are concerns about the safety of JAK inhibitors, including severe heart disease. This article provides an overview of the molecular mechanisms of AD and discusses JAK-related biology as a target for AD treatment.
IMMUNOLOGICAL MEDICINE
(2023)
Article
Dermatology
Hitomi Nakaizumi, Naotomo Kambe, Hiroyuki Irie, Yo Kaku, Masakazu Fujimoto, Hajime Yoshifuji, Yasuhiro Kazuma, Kazumoto Katagiri, Takuro Kanekura, Kenji Kabashima
Summary: Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by bone pain, recurrent fever, and other symptoms. A key feature of the syndrome is the presence of a persistent urticarial-like rash. Histopathological data suggests that neutrophilic epitheliotropism, or the tendency of neutrophils to infiltrate and affect epithelial tissue, can be a useful marker for diagnosing SchS and differentiating it from conventional urticaria. Understanding this characteristic is crucial for early diagnosis and appropriate treatment.
JOURNAL OF DERMATOLOGY
(2023)