Understanding and overcoming antibiotic resistance

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

(2017) Morgan A. Wambaugh et al.   PLOS BIOLOGY

Multidrug-resistant bacteria compensate for the epistasis between resistances

(2017) Jorge Moura de Sousa et al.   PLOS BIOLOGY

Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies

(2017) Pia Abel zur Wiesch et al.   PLoS Computational Biology

Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci

(2017) Joana Rolo et al.   PLoS Genetics

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

(2017) James E Gomez et al.   eLife

Emerging patterns of plasmid-host coevolution that stabilize antibiotic resistance

(2017) Thibault Stalder et al.   Scientific Reports

Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy

(2016) Dilay Hazal Ayhan et al.   PLOS BIOLOGY

Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation

(2016) Robin A. Sorg et al.   PLOS BIOLOGY

Integrating Antimicrobial Therapy with Host Immunity to Fight Drug-Resistant Infections: Classical vs. Adaptive Treatment

(2016) Erida Gjini et al.   PLoS Computational Biology

CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa

(2016) Zhe-Xian Tian et al.   PLoS Pathogens

Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance

(2015) Guillaume Chevereau et al.   PLOS BIOLOGY

Using a Sequential Regimen to Eliminate Bacteria at Sublethal Antibiotic Dosages

(2015) Ayari Fuentes-Hernandez et al.   PLOS BIOLOGY