Multidrug-resistant bacteria compensate for the epistasis between resistances

Epistasis and the Evolution of Antimicrobial Resistance

(2017) Alex Wong   Frontiers in Microbiology

Bacterial Transcription as a Target for Antibacterial Drug Development

(2016) Cong Ma et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Blast from the Past: Reassessing Forgotten Translation Inhibitors, Antibiotic Selectivity, and Resistance Mechanisms to Aid Drug Development

(2016) Stefan Arenz et al.   MOLECULAR CELL

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Transcription is regulated by NusA:NusG interaction

(2016) Martin Strauß et al.   NUCLEIC ACIDS RESEARCH

A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species

(2016) Ákos Nyerges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genomic basis of adaptation to the fitness cost of rifampicin resistance inPseudomonas aeruginosa

(2016) Qin Qi et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Competition and fixation of cohorts of adaptive mutations under Fisher geometrical model

(2016) Jorge A. Moura de Sousa et al.   PeerJ

Genomic investigations of evolutionary dynamics and epistasis in microbial evolution experiments

(2015) Elizabeth R Jerison et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Potential for adaptation overrides cost of resistance

(2015) Jorge Moura de Sousa et al.   Future Microbiology

Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance

(2015) Paulo Durão et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

(2015) Diarmaid Hughes et al.   NATURE REVIEWS GENETICS

Diversity and disease pathogenesis in Mycobacterium tuberculosis

(2015) Digby F. Warner et al.   TRENDS IN MICROBIOLOGY

Exploring RNA polymerase regulation by NMR spectroscopy

(2015) Johanna Drögemüller et al.   Scientific Reports

Determination of RNA polymerase binding surfaces of transcription factors by NMR spectroscopy

(2015) Johanna Drögemüller et al.   Scientific Reports

The rule of declining adaptability in microbial evolution experiments

(2015) Alejandro Couce et al.   Frontiers in Genetics

Antibiotic resistance: An infectious arms race

(2014) Karyn Hede   NATURE

Evolution and transmission of drug-resistant tuberculosis in a Russian population

(2014) Nicola Casali et al.   NATURE GENETICS

Global dissemination of a multidrug resistant Escherichia coli clone

(2014) N. K. Petty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global epistasis makes adaptation predictable despite sequence-level stochasticity

(2014) S. Kryazhimskiy et al.   SCIENCE

RATES OF FITNESS DECLINE AND REBOUND SUGGEST PERVASIVE EPISTASIS

(2013) L. Perfeito et al.   EVOLUTION

An ABC Method for Estimating the Rate and Distribution of Effects of Beneficial Mutations

(2013) Jorge A. Moura de Sousa et al.   Genome Biology and Evolution

Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates

(2013) G. Brandis et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations

(2013) Gregory I. Lang et al.   NATURE

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance

(2013) Hongtai Zhang et al.   NATURE GENETICS

Putative Compensatory Mutations in the rpoC Gene of Rifampin-Resistant Mycobacterium tuberculosis Are Associated with Ongoing Transmission

(2012) M. de Vos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fitness-compensatory mutations in rifampicin-resistant RNA polymerase

(2012) Gerrit Brandis et al.   MOLECULAR MICROBIOLOGY

Horizontal gene transfer boosts MRSA spreading

(2012) André Kriegeskorte et al.   NATURE MEDICINE

Antibiotic Resistance Is Prevalent in an Isolated Cave Microbiome

(2012) Kirandeep Bhullar et al.   PLoS One

The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

(2012) K. J. Forsberg et al.   SCIENCE

BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons

(2011) Nabil-Fareed Alikhan et al.   BMC GENOMICS

Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis

(2011) S. Borrell et al.   CLINICAL MICROBIOLOGY AND INFECTION

EPISTASIS BUFFERS THE FITNESS EFFECTS OF RIFAMPICIN- RESISTANCE MUTATIONS IN PSEUDOMONAS AERUGINOSA

(2011) Alex R. Hall et al.   EVOLUTION

Cost of Antibiotic Resistance and the Geometry of Adaptation

(2011) Ana Sousa et al.   MOLECULAR BIOLOGY AND EVOLUTION

The β Subunit Gate Loop Is Required for RNA Polymerase Modification by RfaH and NusG

(2011) Anastasia Sevostyanova et al.   MOLECULAR CELL

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes

(2011) Iñaki Comas et al.   NATURE GENETICS

Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

(2011) H.-H. Chou et al.   SCIENCE

Second-Order Selection for Evolvability in a Large Escherichia coli Population

(2011) R. J. Woods et al.   SCIENCE

Selection of Resistant Bacteria at Very Low Antibiotic Concentrations

(2011) Erik Gullberg et al.   PLoS Pathogens

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Escherichia coli rpoB Mutants Have Increased Evolvability in Proportion to Their Fitness Defects

(2010) J. E. Barrick et al.   MOLECULAR BIOLOGY AND EVOLUTION

A NusE:NusG Complex Links Transcription and Translation

(2010) B. M. Burmann et al.   SCIENCE

Emergence of New Forms of Totally Drug-Resistant Tuberculosis Bacilli

(2009) Ali Akbar Velayati et al.   CHEST

Positive Epistasis Drives the Acquisition of Multidrug Resistance

(2009) Sandra Trindade et al.   PLoS Genetics