Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease
出版年份 2017 全文链接
标题
Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease
作者
关键词
-
出版物
Frontiers in Aging Neuroscience
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2017-06-08
DOI
10.3389/fnagi.2017.00176
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Neuroprotective Effects of Loganin on MPTP-Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies
- (2017) Yi-Da Xu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Induction of Adaptive Immunity Leads to Nigrostriatal Disease Progression in MPTP Mouse Model of Parkinson’s Disease
- (2017) Goutam Chandra et al. JOURNAL OF IMMUNOLOGY
- Pathological α-synuclein exacerbates the progression of Parkinson’s disease through microglial activation
- (2017) Qiu-Shuang Zhang et al. TOXICOLOGY LETTERS
- Neuroprotective Role of Atractylenolide-I in an In Vitro and In Vivo Model of Parkinson’s Disease
- (2017) et al. Nutrients
- Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway
- (2017) Haoran Jing et al. PLoS One
- Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology
- (2016) Nicolas Dzamko et al. ACTA NEUROPATHOLOGICA
- Vitamin D Treatment Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in an Animal Model of Parkinson’s Disease, Shifting M1 to M2 Microglia Responses
- (2016) Rosa Calvello et al. Journal of Neuroimmune Pharmacology
- Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease
- (2016) Anamitra Ghosh et al. Journal of Neuroimmune Pharmacology
- Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers
- (2016) Nicolas Dzamko et al. MOVEMENT DISORDERS
- Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra
- (2016) Yang Heng et al. TOXICOLOGY LETTERS
- Cannabinoid Type 2 (CB2) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease
- (2016) Hayate Javed et al. Frontiers in Neuroscience
- Vagotomy and subsequent risk of Parkinson's disease
- (2015) Elisabeth Svensson et al. ANNALS OF NEUROLOGY
- Roles of microglia in brain development, tissue maintenance and repair
- (2015) Mackenzie A. Michell-Robinson et al. BRAIN
- Microglial M1/M2 polarization and metabolic states
- (2015) Ruben Orihuela et al. BRITISH JOURNAL OF PHARMACOLOGY
- New FDA-Approved Disease-Modifying Therapies for Multiple Sclerosis
- (2015) Clayton English et al. CLINICAL THERAPEUTICS
- Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation
- (2015) Emiliano Peña-Altamira et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model
- (2015) WEI YANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
- (2015) João P. L. Daher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson׳s disease
- (2015) Shaoxia Wang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
- (2015) Isabella Russo et al. Journal of Neuroinflammation
- Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial
- (2015) LANCET NEUROLOGY
- Clinical correlation of peripheral CD4+-cell sub-sets, their imbalance and Parkinson's disease
- (2015) YUHUA CHEN et al. Molecular Medicine Reports
- α-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTP-induced behavioral deficits in a mouse model of Parkinson's disease
- (2015) Byung-Wook Kim et al. NEUROPHARMACOLOGY
- M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?
- (2015) M.S. Moehle et al. NEUROSCIENCE
- Identification of CB2 receptors in human nigral neurons that degenerate in Parkinson’s disease
- (2015) María Concepción García et al. NEUROSCIENCE LETTERS
- Diversity and plasticity of microglial cells in psychiatric and neurological disorders
- (2015) Yutaka Nakagawa et al. PHARMACOLOGY & THERAPEUTICS
- Alternatively activated microglia and macrophages in the central nervous system
- (2015) Rafael Franco et al. PROGRESS IN NEUROBIOLOGY
- Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
- (2014) Staffan Holmqvist et al. ACTA NEUROPATHOLOGICA
- The future of JAK inhibition in myelofibrosis and beyond
- (2014) John O. Mascarenhas et al. BLOOD REVIEWS
- Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism
- (2014) Salvador Sierra et al. Brain Structure & Function
- CD200R1 and CD200 expression are regulated by PPAR-γ in activated glial cells
- (2014) Guido Dentesano et al. GLIA
- Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases
- (2014) Hugo González et al. JOURNAL OF NEUROIMMUNOLOGY
- Induction of GDNF and BDNF by hRheb(S16H) Transduction of SNpc Neurons: Neuroprotective Mechanisms of hRheb(S16H) in a Model of Parkinson’s Disease
- (2014) Jin Han Nam et al. MOLECULAR NEUROBIOLOGY
- The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model
- (2014) Diana Fernández-Suárez et al. NEUROBIOLOGY OF AGING
- Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease
- (2014) Augusta Pisanu et al. NEUROBIOLOGY OF DISEASE
- Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease
- (2014) Maciej Świątkiewicz et al. Pharmacological Reports
- Effect of human interleukin-10 on the expression of nitric oxide synthases in the MPTP-based model of Parkinson's disease
- (2014) Joanna Schwenkgrub et al. Pharmacological Reports
- The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease
- (2014) Ilona Joniec-Maciejak et al. Pharmacological Reports
- Abrogation of -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
- (2014) J. P. L. Daher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
- (2013) Vibol Chhor et al. BRAIN BEHAVIOR AND IMMUNITY
- Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease
- (2013) Y Tang et al. CELL DEATH AND DIFFERENTIATION
- Caudo-rostral brain spreading of α-synuclein through vagal connections
- (2013) Ayse Ulusoy et al. EMBO Molecular Medicine
- Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis
- (2013) Debora Giunti et al. IMMUNOLOGY
- Therapeutic Efficacy of Suppressing the JAK/STAT Pathway in Multiple Models of Experimental Autoimmune Encephalomyelitis
- (2013) Y. Liu et al. JOURNAL OF IMMUNOLOGY
- Fingolimod phosphate promotes the neuroprotective effects of microglia
- (2013) Hiromi Noda et al. JOURNAL OF NEUROIMMUNOLOGY
- Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
- (2013) Daphne YS Vogel et al. Journal of Neuroinflammation
- Characterization of peripheral hematopoietic stem cells and monocytes in Parkinson's disease
- (2013) Natalja Funk et al. MOVEMENT DISORDERS
- Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol
- (2013) Mohammad Moshahid Khan et al. NEUROCHEMISTRY INTERNATIONAL
- Microglia: Multiple roles in surveillance, circuit shaping, and response to injury
- (2013) E. E. Benarroch NEUROLOGY
- Microglia, Amyloid and Glucose Metabolism in Parkinson’s Disease with and without Dementia
- (2013) Paul Edison et al. NEUROPSYCHOPHARMACOLOGY
- Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia
- (2013) Robert W. Freilich et al. PLoS One
- Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation
- (2013) Cintia Roodveldt et al. PLoS One
- Factors regulating microglia activation
- (2013) Katrin Kierdorf et al. Frontiers in Cellular Neuroscience
- The role of LRRK2 in inflammatory bowel disease
- (2012) Zhihua Liu et al. CELL RESEARCH
- Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein
- (2012) Melanie B. Watson et al. EXPERIMENTAL NEUROLOGY
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- Innate immunity in the central nervous system
- (2012) Richard M. Ransohoff et al. JOURNAL OF CLINICAL INVESTIGATION
- Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models
- (2012) D. C. Lacey et al. JOURNAL OF IMMUNOLOGY
- Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein
- (2012) Dawn Béraud et al. Journal of Neuroimmune Pharmacology
- CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease
- (2012) Jessica A. Hutter Saunders et al. Journal of Neuroimmune Pharmacology
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease
- (2012) S. Mandrekar-Colucci et al. JOURNAL OF NEUROSCIENCE
- Review: Activation patterns of microglia and their identification in the human brain
- (2012) D. Boche et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates
- (2012) P. Barkholt et al. NEUROSCIENCE
- A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice
- (2012) Marie-Francoise Chesselet et al. Neurotherapeutics
- In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease
- (2012) S. Iannaccone et al. PARKINSONISM & RELATED DISORDERS
- Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
- (2012) Francisco Pan-Montojo et al. Scientific Reports
- Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration
- (2011) Sang Ryong Kim et al. ANNALS OF NEUROLOGY
- Taming of macrophage and microglial cell activation by microRNA-124
- (2011) Ashley T Conrad et al. CELL RESEARCH
- Microglia Phenotype Diversity
- (2011) M. Olah et al. CNS & Neurological Disorders-Drug Targets
- NSAID use and risk of Parkinson disease: a population-based case-control study
- (2011) C. Becker et al. EUROPEAN JOURNAL OF NEUROLOGY
- A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci
- (2011) A. Singleton et al. HUMAN MOLECULAR GENETICS
- Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria
- (2011) S. Schmidt et al. HUMAN MOLECULAR GENETICS
- Expression of mutant alpha-synuclein modulates microglial phenotype in vitro
- (2011) Lalida Rojanathammanee et al. Journal of Neuroinflammation
- AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth
- (2011) Sang Ryong Kim et al. MOLECULAR THERAPY
- Use of ibuprofen and risk of Parkinson disease
- (2011) X. Gao et al. NEUROLOGY
- Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model
- (2011) A.R. Carta et al. NEUROSCIENCE
- Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice
- (2011) Ravi S. Akundi et al. PLoS One
- Evidence for More than One Parkinson's Disease-Associated Variant within the HLA Region
- (2011) Erin M. Hill-Burns et al. PLoS One
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- Nomenclature of monocytes and dendritic cells in blood
- (2010) L. Ziegler-Heitbrock et al. BLOOD
- Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice
- (2010) A. Florence Keller et al. EXPERIMENTAL NEUROLOGY
- Antioxidative and Anti-Inflammatory Protection from Carnosine in the Striatum of MPTP-Treated Mice
- (2010) Shih-Jei Tsai et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- LRRK2 Is Involved in the IFN- Response and Host Response to Pathogens
- (2010) A. Gardet et al. JOURNAL OF IMMUNOLOGY
- Parkinson’s disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans
- (2010) Elena M. Cornejo Castro et al. JOURNAL OF NEURAL TRANSMISSION
- Ulcerative colitis exacerbates lipopolysaccharide-induced damage to the nigral dopaminergic system: potential risk factor in Parkinson`s disease
- (2010) Ruth F. Villarán et al. JOURNAL OF NEUROCHEMISTRY
- Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation
- (2010) Henrik Wilms et al. Journal of Neuroinflammation
- The Toll-Like Receptor-3 Agonist Polyinosinic:Polycytidylic Acid Triggers Nigrostriatal Dopaminergic Degeneration
- (2010) M. Deleidi et al. JOURNAL OF NEUROSCIENCE
- Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis
- (2010) José L Lanciego et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease
- (2010) Ashley S Harms et al. MOLECULAR THERAPY
- The myeloid cells of the central nervous system parenchyma
- (2010) Richard M. Ransohoff et al. NATURE
- Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
- (2010) Taye H Hamza et al. NATURE GENETICS
- Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis
- (2010) J. J. Gagne et al. NEUROLOGY
- Role of microglia in neurotrauma
- (2010) David J. Loane et al. Neurotherapeutics
- Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice
- (2010) Francisco Pan-Montojo et al. PLoS One
- Changing Face of Microglia
- (2010) M. B. Graeber SCIENCE
- Microglial Interactions with Synapses Are Modulated by Visual Experience
- (2010) Marie-Ève Tremblay et al. PLOS BIOLOGY
- Parkinson's Disease
- (2009) Christopher H. Hawkes et al. Annals of the New York Academy of Sciences
- NSAID Use and the Risk of Parkinsonʼs Disease
- (2009) Ali Samii et al. DRUGS & AGING
- WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease
- (2009) David A. Price et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases
- (2009) Xiaoyu Hu et al. IMMUNITY
- Differential gene expression in LPS/IFNγ activated microglia and macrophages:in vitroversusin vivo
- (2009) Christoph D. Schmid et al. JOURNAL OF NEUROCHEMISTRY
- Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β
- (2009) Alessandro Michelucci et al. JOURNAL OF NEUROIMMUNOLOGY
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Neuroinflammation in Parkinson's disease: a target for neuroprotection?
- (2009) Etienne C Hirsch et al. LANCET NEUROLOGY
- Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity
- (2009) Xiaomin Su et al. NEUROTOXICITY RESEARCH
- Neuroprotective Effect of Ghrelin in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson’s Disease by Blocking Microglial Activation
- (2009) Minho Moon et al. NEUROTOXICITY RESEARCH
- Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1 in human monocytes and multiple sclerosis
- (2009) D. Burger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The influence of microglia on the pathogenesis of Parkinson's disease
- (2009) Caitríona M. Long-Smith et al. PROGRESS IN NEUROBIOLOGY
- Debris clearance by microglia: an essential link between degeneration and regeneration
- (2008) H. Neumann et al. BRAIN
- A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease
- (2008) CLINICAL NEUROPHARMACOLOGY
- Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra
- (2008) Hong Jiang et al. EXPERIMENTAL NEUROLOGY
- The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery
- (2008) Garima Dutta et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- Microglial cells and Parkinson’s disease
- (2008) Li Qian et al. IMMUNOLOGIC RESEARCH
- Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
- (2008) Vanessa Brochard et al. JOURNAL OF CLINICAL INVESTIGATION
- Production and functions of IL-17 in microglia
- (2008) Jun Kawanokuchi et al. JOURNAL OF NEUROIMMUNOLOGY
- Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease
- (2008) Shaji Theodore et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats
- (2008) Melissa K McCoy et al. MOLECULAR THERAPY
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
- (2008) Jeffrey C Barrett et al. NATURE GENETICS
- Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?
- (2008) R.J. Phillips et al. NEUROSCIENCE
- Synuclein activates microglia in a model of Parkinson's disease
- (2007) Xiaomin Su et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started