The Role of Nuclear Receptor–Binding SET Domain Family Histone Lysine Methyltransferases in Cancer

A PWWP Domain of Histone-LysineN-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin

(2016) Saumya M. Sankaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleosome Binding Alters the Substrate Bonding Environment of Histone H3 Lysine 36 Methyltransferase NSD2

(2016) Myles B. Poulin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for PHDVC5HCHNSD1–C2HRNizp1interaction: implications for Sotos syndrome

(2016) Andrea Berardi et al.   NUCLEIC ACIDS RESEARCH

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

(2016) M Y Shah et al.   ONCOGENE

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

(2016) Brandon L. Crowe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36

(2016) Myles B. Poulin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic behavior of the post-SET loop region of NSD1: Implications for histone binding and drug development

(2016) Sarah E. Graham et al.   PROTEIN SCIENCE

NUT carcinoma of the thorax: Case report and review of the literature

(2015) Alexander Harms et al.   LUNG CANCER

NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler

(2015) Chen Shen et al.   MOLECULAR CELL

NSD3-NUT-expressing midline carcinoma of the lung: First characterization of primary cancer tissue

(2015) Shioto Suzuki et al.   PATHOLOGY RESEARCH AND PRACTICE

TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

(2015) Arshan Perera et al.   Cell Reports

A Sensitive Luminescent Assay for the Histone Methyltransferase NSD1 and Other SAM-Dependent Enzymes

(2014) Katherine M. Drake et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Substrate Specificity Analysis and Novel Substrates of the Protein Lysine Methyltransferase NSD1

(2014) Srikanth Kudithipudi et al.   CHEMISTRY & BIOLOGY

Potent co-operation between the NUP98-NSD1 fusion and the FLT3-ITD mutation in acute myeloid leukemia induction

(2014) A. Thanasopoulou et al.   HAEMATOLOGICA

Neural crest specification and migration independently require NSD3-related lysine methyltransferase activity

(2014) Bridget T. Jacques-Fricke et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets

(2014) Ying Chen et al.   PLoS One

NSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma: Implications for a Novel Oncogenic Mechanism

(2014) C. A. French et al.   Cancer Discovery

Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

(2014) Relja Popovic et al.   PLoS Genetics

PPAPDC1B and WHSC1L1 Are Common Drivers of the 8p11-12 Amplicon, Not Only in Breast Tumors But Also in Pancreatic Adenocarcinomas and Lung Tumors

(2013) Sardar F. Mahmood et al.   AMERICAN JOURNAL OF PATHOLOGY

NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma

(2013) Z. Huang et al.   CANCER RESEARCH

Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies

(2013) J A Oyer et al.   LEUKEMIA

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

(2013) Jacob D Jaffe et al.   NATURE GENETICS

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

(2013) S. Bea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SET for life: biochemical activities and biological functions of SET domain-containing proteins

(2013) Hans-Martin Herz et al.   TRENDS IN BIOCHEMICAL SCIENCES

The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis

(2012) Daechun Kang et al.   GENES CHROMOSOMES & CANCER

The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition

(2012) Chao He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Transposon-Based Analysis of Gene Mutations Related to Skin Cancer Development

(2012) Rita M. Quintana et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Generation of the Sotos syndrome deletion in mice

(2012) Anna M. Migdalska et al.   MAMMALIAN GENOME

Characterization of the EZH2-MMSET Histone Methyltransferase Regulatory Axis in Cancer

(2012) Irfan A. Asangani et al.   MOLECULAR CELL

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mining Gene Expression Signature for the Detection of Pre-Malignant Melanocytes and Early Melanomas with Risk for Metastasis

(2012) Camila Ferreira de Souza et al.   PLoS One

Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

(2012) K. M. Mann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in EZH2 Cause Weaver Syndrome

(2011) William T. Gibson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma

(2011) H. R. Hudlebusch et al.   CANCER RESEARCH

The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors

(2011) H. R. Hudlebusch et al.   CLINICAL CANCER RESEARCH

The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation

(2011) Qi Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

(2011) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3

(2011) S. Rahman et al.   MOLECULAR AND CELLULAR BIOLOGY

NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

(2011) Alex J. Kuo et al.   MOLECULAR CELL

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

(2011) Hong Wu et al.   PLoS One

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

(2011) Ildiko Hajdu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells

(2010) Zhangle Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

(2010) E. Martinez-Garcia et al.   BLOOD

Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

(2010) T. Bianco-Miotto et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Transforming Properties of 8p11-12 Amplified Genes in Human Breast Cancer

(2010) Z.-Q. Yang et al.   CANCER RESEARCH

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

NSD1 PHD domains bind methylated H3K4 and H3K9 using interactions disrupted by point mutations in human sotos syndrome

(2010) Martina P. Pasillas et al.   HUMAN MUTATION

Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 Methylation

(2010) Rui Fang et al.   MOLECULAR CELL

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function

(2010) A. K. Lucio-Eterovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NUP98–NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes

(2009) Takeshi Taketani et al.   CANCER GENETICS AND CYTOGENETICS

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate

(2009) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone H3 Lysine 36 Dimethylation (H3K36me2) Is Sufficient to Recruit the Rpd3s Histone Deacetylase Complex and to Repress Spurious Transcription

(2009) Bing Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased Chromatin Signatures around Polyadenylation Sites and Exons

(2009) Noah Spies et al.   MOLECULAR CELL

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

(2009) Keisuke Nimura et al.   NATURE

Processing the H3K36me3 signature

(2009) Robert J Sims III et al.   NATURE GENETICS

Differential chromatin marking of introns and expressed exons by H3K36me3

(2009) Paulina Kolasinska-Zwierz et al.   NATURE GENETICS

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

(2009) M. Berdasco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

(2008) J. L.R. Brito et al.   HAEMATOLOGICA

Multiple Myeloma-Related WHSC1/MMSET Isoform RE-IIBP Is a Histone Methyltransferase with Transcriptional Repression Activity

(2008) J.-Y. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

(2008) Lindsey A. Baker et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Effect of histone deacetylase inhibitor on proliferation of biliary tract cancer cell lines

(2008) Li-Ning Xu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

(2007) J. Marango et al.   BLOOD

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity

(2007) J. Lauring et al.   BLOOD