Dynamic behavior of the post-SET loop region of NSD1: Implications for histone binding and drug development

Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase

(2015) David S. Rogawski et al.   BIOCHEMISTRY

Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2

(2014) Kanchan Devkota et al.   ACS Medicinal Chemistry Letters

Strategy to Target the Substrate Binding site of SET Domain Protein Methyltransferases

(2013) Kong T. Nguyen et al.   Journal of Chemical Information and Modeling

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

Rational Approaches to Improving Selectivity in Drug Design

(2012) David J. Huggins et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2

(2012) Weihong Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Structural insights into the regulation and the recognition of histone marks by the SET domain of NSD1

(2011) Masayo Morishita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methylation

(2011) Qi Qiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Human Histone Methyltransferase ASH1L Catalytic Domain and Its Implications for the Regulatory Mechanism

(2011) Sojin An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKaValues

(2011) Chresten R. Søndergaard et al.   Journal of Chemical Theory and Computation

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a

(2011) Yanqi Chang et al.   Nature Communications

Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.

(2010) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

(2010) Yanqi Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Biology of Human H3K9 Methyltransferases

(2010) Hong Wu et al.   PLoS One

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate

(2009) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Requirement of Additional Factors for MLL1 SET Domain Activity and Recognition of Epigenetic Marks

(2009) Stacey M. Southall et al.   MOLECULAR CELL

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma

(2009) M. Berdasco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA