The Bone Marrow Microenvironment in Health and Myeloid Malignancy

Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor-treated CML stem cells

(2016) B. Zhang et al.   BLOOD

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells

(2016) Kevin A. Goncalves et al.   CELL

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

(2016) Noemi A. Zambetti et al.   Cell Stem Cell

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators

(2016) Lev Silberstein et al.   Cell Stem Cell

Phenotypic, genotypic, and functional characterization of normal and acute myeloid leukemia-derived marrow endothelial cells

(2016) Russell J. Pizzo et al.   EXPERIMENTAL HEMATOLOGY

Chemosensitizing AML cells by targeting bone marrow endothelial cells

(2016) Raphael C. Bosse et al.   EXPERIMENTAL HEMATOLOGY

Chronic myelogenous leukaemia exosomes modulate bone marrow microenvironment through activation of epidermal growth factor receptor

(2016) Chiara Corrado et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis

(2016) Srdan Verstovsek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs

(2016) S Chen et al.   LEUKEMIA

Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients

(2016) E K von der Heide et al.   LEUKEMIA

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

(2016) James Y. Chen et al.   NATURE

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

(2016) Lei Dong et al.   NATURE

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells

(2016) Andreas Reinisch et al.   NATURE MEDICINE

Enhanced Hematopoietic Stem Cell Self-Renewal-Promoting Ability of Clonal Primary Mesenchymal Stromal/Stem cells Versus Their Osteogenic Progeny

(2016) Qiling He et al.   STEM CELLS

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo

(2016) Claire S. Koechlein et al.   Nature Communications

Microvesicles from Mesenchymal Stromal Cells Are Involved in HPC-Microenvironment Crosstalk in Myelodysplastic Patients

(2016) Sandra Muntión et al.   PLoS One

The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells

(2016) Jing-Yi Chen et al.   Scientific Reports

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

(2015) J. Paggetti et al.   BLOOD

Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

(2015) M. Bowers et al.   BLOOD

Microenvironmental Remodeling as a Parameter and Prognostic Factor of Heterogeneous Leukemogenesis in Acute Myelogenous Leukemia

(2015) Jin-A Kim et al.   CANCER RESEARCH

Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models

(2015) J. Benito et al.   CLINICAL CANCER RESEARCH

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance

(2015) Milica Vukovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia

(2015) S Geyh et al.   LEUKEMIA

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

(2015) J Huan et al.   LEUKEMIA

FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice

(2015) A Kode et al.   LEUKEMIA

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

(2015) Xiaolin Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic and epigenetic alterations of bone marrow stromal cells in myelodysplastic syndrome and acute myeloid leukemia patients

(2015) Yonggoo Kim et al.   Stem Cell Research

Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells

(2015) Chen Glait-Santar et al.   STEM CELLS

Mesenchymal stromal cells derived from acute myeloid leukemia bone marrow exhibit aberrant cytogenetics and cytokine elaboration

(2015) J C Huang et al.   Blood Cancer Journal

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

(2014) M. Krevvata et al.   BLOOD

Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy

(2014) Cai-Wen Duan et al.   CANCER CELL

Notch-Dependent Repression of miR-155 in the Bone Marrow Niche Regulates Hematopoiesis in an NF-κB-Dependent Manner

(2014) Lin Wang et al.   Cell Stem Cell

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

Overexpression of CDKN2B (p15INK4B) and altered global DNA methylation status in mesenchymal stem cells of high-risk myelodysplastic syndromes

(2014) A Poloni et al.   LEUKEMIA

Functional integration of acute myeloid leukemia into the vascular niche

(2014) C R Cogle et al.   LEUKEMIA

Functional and genetic aberrations of in vitro-cultured marrow-derived mesenchymal stromal cells of patients with classical Philadelphia-negative myeloproliferative neoplasms

(2014) M A Avanzini et al.   LEUKEMIA

Direct measurement of local oxygen concentration in the bone marrow of live animals

(2014) Joel A. Spencer et al.   NATURE

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

(2014) Lorena Arranz et al.   NATURE

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells

(2013) Noboru Asada et al.   Cell Stem Cell

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

HIF-2α Protects Human Hematopoietic Stem/Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress

(2013) Kevin Rouault-Pierre et al.   Cell Stem Cell

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells

(2013) S Geyh et al.   LEUKEMIA

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

Myelopoiesis is regulated by osteocytes through Gs -dependent signaling

(2012) K. Fulzele et al.   BLOOD

Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells

(2012) L. M. Calvi et al.   BLOOD

RNA Trafficking by Acute Myelogenous Leukemia Exosomes

(2012) J. Huan et al.   CANCER RESEARCH

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Fighting science with politics

(2012)   NATURE MEDICINE

Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts

(2011) O. Blau et al.   BLOOD

Differential niche and Wnt requirements during acute myeloid leukemia progression

(2011) S. W. Lane et al.   BLOOD

The relationship between bone, hemopoietic stem cells, and vasculature

(2011) S. L. Ellis et al.   BLOOD

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

(2011) B. J. Frisch et al.   BLOOD

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Musculoskeletal Manifestations in Pediatric Acute Leukemia

(2011) Riccardo Sinigaglia et al.   JOURNAL OF PEDIATRIC ORTHOPAEDICS

Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential

(2010) J. Grassinger et al.   BLOOD

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with  9 1 and  4 1 integrins

(2009) J. Grassinger et al.   BLOOD

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

(2009) M. J. Christopher et al.   BLOOD

Blood-forming stem cells are nervous: Direct and indirect regulation of immature human CD34+ cells by the nervous system

(2009) Alexander Kalinkovich et al.   BRAIN BEHAVIOR AND IMMUNITY

Bone marrow mesenchymal stromal cells remain of recipient origin after allogeneic SCT and do not harbor the JAK2V617F mutation in patients with myelofibrosis

(2009) Ulrike Bacher et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Bone marrow mesenchymal stromal cells of patients with myeloproliferative disorders do not carry the JAK2-V617F mutation

(2009) François Mercier et al.   EXPERIMENTAL HEMATOLOGY

Both expanded and uncultured mesenchymal stem cells from MDS patients are genomically abnormal, showing a specific genetic profile for the 5q− syndrome

(2009) O Lopez-Villar et al.   LEUKEMIA

Reserves, Functional, Immunoregulatory, and Cytogenetic Properties of Bone Marrow Mesenchymal Stem Cells in Patients with Myelodysplastic Syndromes

(2009) Mirjam Klaus et al.   STEM CELLS AND DEVELOPMENT

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

(2008) Z. Zeng et al.   BLOOD

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

(2008) B. Nervi et al.   BLOOD

TGF-  as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation

(2008) S. Yamazaki et al.   BLOOD

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

(2008) Cristina Lo Celso et al.   NATURE

Detection of functional haematopoietic stem cell niche using real-time imaging

(2008) Yucai Xie et al.   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Osteoblastic regulation of B lymphopoiesis is mediated by Gs -dependent signaling pathways

(2008) J. Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE

The Myelopoietic Supportive Capacity of Mesenchymal Stromal Cells Is Uncoupled from Multipotency and Is Influenced by Lineage Determination and Interference with Glycosylation

(2008) Vered Morad et al.   STEM CELLS

Mesenchymal stem cells from JAK2V617F mutant patients with primary myelofibrosis do not harbor JAK2 mutant allele

(2007) Lisa Pieri et al.   LEUKEMIA RESEARCH