Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

(2013) B. Boyerinas et al.   BLOOD

Stem cell factor expression in B cell malignancies is influenced by the niche

(2013) Matthew F. Fox et al.   LEUKEMIA & LYMPHOMA

Differential regulation of myeloid leukemias by the bone marrow microenvironment

(2013) Daniela S Krause et al.   NATURE MEDICINE

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

(2012) H. J. Pegram et al.   BLOOD

Myelopoiesis is regulated by osteocytes through Gs -dependent signaling

(2012) K. Fulzele et al.   BLOOD

FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin

(2012) Aruna Kode et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Differential niche and Wnt requirements during acute myeloid leukemia progression

(2011) S. W. Lane et al.   BLOOD

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

(2011) B. J. Frisch et al.   BLOOD

Efficacy of serotonin inhibition in mouse models of bone loss

(2011) Hiroyuki Inose et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism

(2011) Yoshihiro Yoshikawa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

(2011) Kana Miyamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Musculoskeletal Manifestations in Pediatric Acute Leukemia

(2011) Riccardo Sinigaglia et al.   JOURNAL OF PEDIATRIC ORTHOPAEDICS

Combined therapy with the RANKL inhibitor RANK-Fc and rhApo2L/TRAIL/dulanermin reduces bone lesions and skeletal tumor burden in a model of breast cancer skeletal metastasis

(2010) Pamela M. Holland et al.   CANCER BIOLOGY & THERAPY

The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization

(2010) J-P Lévesque et al.   LEUKEMIA

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

(2010) Eva Gonzalez-Suarez et al.   NATURE

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

(2010) Vijay K Yadav et al.   NATURE MEDICINE

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Defective Notch activation in microenvironment leads to myeloproliferative disease

(2008) Y.-W. Kim et al.   BLOOD

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3

(2008) Viktor Janzen et al.   Cell Stem Cell

Endochondral ossification is required for haematopoietic stem-cell niche formation

(2008) Charles K. F. Chan et al.   NATURE

Osteoblastic regulation of B lymphopoiesis is mediated by Gs -dependent signaling pathways

(2008) J. Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE