Review
Cell Biology
Nancy C. C. Allen, Nabora S. S. Reyes, Jin Young Lee, Tien Peng
Summary: Aging is the final stage of development that leads to stereotyped changes in tissue morphology and increases the risk of chronic lung diseases. Inflammation and cellular senescence, two hallmarks of aging, are mutually related and contribute to increased susceptibility to chronic diseases in aging tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Ruchi Kumari, Parmjit Jat
Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Jing Yang, Mengmeng Liu, Dongchun Hong, Musheng Zeng, Xing Zhang
Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Yongyu He, Wenqing Xie, Hengzhen Li, Hongfu Jin, Yi Zhang, Yusheng Li
Summary: Aging promotes degenerative pathologies in mammals, including sarcopenia. New findings suggest that age-related sarcopenia can be delayed by modulating mechanisms such as cellular senescence. Studies have shown that targeting cellular senescence is an effective strategy for alleviating sarcopenia. However, more research is needed to understand the mechanisms through which senescent cells contribute to sarcopenia progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ryan Wallis, Natasa Josipovic, Hannah Mizen, Arturo Robles-Tenorio, Eleanor J. Tyler, Argyris Papantonis, Cleo L. Bishop
Summary: The secretion of small extracellular vesicles (EVs) by senescent cells is found to play an important role in aging and age-related pathologies. Separating the soluble SASP from the vesicular component helps clarify the functional significance of EVs and provides a framework for future investigations.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Review
Biochemistry & Molecular Biology
Mahmoud Al-Azab, Mohammed Safi, Elina Idiiatullina, Fadhl Al-Shaebi, Mohamed Y. Zaky
Summary: Human mesenchymal stem cells (MSCs) play important roles in tissue homeostasis, aging-related diseases, and cellular therapy. Understanding the mechanisms and signs of MSC cellular senescence is crucial for combating aging and cellular senescence. This review discusses the factors contributing to MSC senescence and strategies to reverse it.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Cell Biology
Akaitz Dorronsoro, Fernando E. Santiago, Diego Grassi, Tianpeng Zhang, Ruenn Chai Lai, Sara J. McGowan, Luise Angelini, Mitra Lavasani, Lana Corbo, Aiping Lu, Robert W. Brooks, Marta Garcia-Contreras, Donna B. Stolz, Antonio Amelio, Siddaraju V. Boregowda, Mohammad Fallahi, Adrian Reich, Camillo Ricordi, Donald G. Phinney, Johnny Huard, Sai Kiang Lim, Laura J. Niedernhofer, Paul D. Robbins
Summary: The injection of BM-MSCs from young mice can prolong lifespan and healthspan, while conditioned media (CM) from young BM-MSCs can rescue the function of aged stem cells and senescent fibroblasts. Extracellular vesicles (EVs) from young BM-MSC CM can extend lifespan in mice, and EVs from MSCs generated from human ES cells can reduce senescence and improve healthspan.
Review
Cell Biology
Mikolaj Ogrodnik
Summary: The field of cellular senescence research has expanded rapidly from in vitro studies of aging to animal and clinical research, focusing on the role of senescence markers in aging, disease, and anti-senescence interventions. The presence and role of these markers in cells prior to cell cycle arrest, particularly in replicative aging and in vivo conditions, are discussed. The article also explores disparities in quantifications of senescence markers in vivo and the applicational value of broadening the cellular senescence paradigm.
Review
Cell Biology
Runjiu Zhu, Haoyang Wan, Hong Yang, Mingrui Song, Yu Chai, Bin Yu
Summary: With the increasing proportion of older individuals in most countries, the prevalence of osteoporosis has been on the rise, leading scientists to focus on the pathogenic mechanisms of this condition. In recent years, research on cellular senescence has shed light on the role of the senescent microenvironment in osteoporosis. Senescent cells in the bone marrow secrete senescence-associated secretory phenotype (SASP) factors, which can impact both their own function and the surrounding healthy cells, exacerbating the aging process. The composition of SASP may vary depending on the cause of osteoporosis. This review summarizes the relationship between SASP factors and osteoporosis and provides new insights for the investigation of its mechanism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Giorgia Manni, Sandra Buratta, Maria Teresa Pallotta, Davide Chiasserini, Alessandro Di Michele, Carla Emiliani, Stefano Giovagnoli, Luisa Pascucci, Rita Romani, Ilaria Bellezza, Lorena Urbanelli, Francesca Fallarino
Summary: Extracellular vesicles (EVs) are membrane-enclosed particles secreted by cells and circulating in body fluids. They not only serve as a tool for waste disposal, but also transmit cell signals. Aging is characterized by genomic instability, telomere erosion, epigenetic alteration, and defective proteostasis. Studies have shown that EVs released in cell models are associated with these aging hallmarks and can spread senescence signals. Furthermore, EVs have great potential as anti-aging tools. Although this is a recent field, altered EV secretion in aging suggests it as an emerging hallmark of aging.
Review
Geriatrics & Gerontology
Wen-juan Wang, Xiang-mei Chen, Guang-yan Cai
Summary: Renal fibrosis plays a crucial role in chronic kidney disease, but the complex and unclear pathological process hinders effective treatment. Cellular senescence and the SASP are reported to cause renal fibrosis, and inhibiting them may be a potential strategy for prevention and treatment. Emerging interventions targeting the SASP, caloric restriction and mimetics, as well as novel regeneration therapies with stem cells, show promising therapeutic strategies.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Pharmacology & Pharmacy
Paul D. Robbins, Diana Jurk, Sundeep Khosla, James L. Kirkland, Nathan K. LeBrasseur, Jordan D. Miller, Joao F. Passos, Robert J. Pignolo, Tamar Tchkonia, Laura J. Niedernhofer
Summary: Senescence is a signaling mechanism activated in stressed cells to prevent proliferation of damaged cells, leading to chronic sterile inflammation and age-related diseases. Senescent cells accumulate with age and in diseased anatomical sites, making them a logical therapeutic target. Senotherapeutics, a new class of drugs, selectively kill senescent cells or suppress their disease-causing phenotypes, showing promising results in preclinical studies and clinical trials.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Peripheral Vascular Disease
Zachary S. Clayton, Matthew J. Rossman, Sophia A. Mahoney, Ravinandan Venkatasubramanian, Grace S. Maurer, David A. Hutton, Nicholas S. Vandongen, Nathan T. Greenberg, Abigail G. Longtine, Katelyn R. Ludwig, Vienna E. Brunt, Thomas J. Larocca, Judith Campisi, Simon Melov, Douglas R. Seals
Summary: Cellular senescence and the senescence associated secretory phenotype (SASP) contribute to vascular aging, and clearance of senescent cells holds promise for improving age-related vascular function.
Article
Biochemistry & Molecular Biology
Xiaojing Du, Xingxing Zhang, Zhuoran Qi, Ziyi Zeng, Ye Xu, Zhijie Yu, Xin Cao, Jinglin Xia
Summary: This study investigated the relationship between the senescence-associated secretory phenotype (SASP) and stemness in intrahepatic cholangiocarcinoma (ICC). The researchers identified senescence-related stemness genes (SRSGs) in ICC and established a classification based on these genes. They also developed a risk score model for ICC and found positive correlations between the risk score, stemness, immune infiltration, metabolism, and oncogenic signatures in ICC. Additionally, the study demonstrated the up-regulation of HELLS, a SRSG, in tumor-repopulating cells with stemness features and its role in colony size, migration, invasion, and SASP in ICC.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Oleh Lushchak, Markus Schosserer, Johannes Grillari
Summary: Cellular senescence refers to a stable cell cycle arrest state with specific characteristics. Senescent cells accumulate in the body during normal aging, limiting lifespan and promoting aging-related as well as unrelated diseases. Diseases associated with cellular senescence are referred to as senopathies, and targeting senescent cells through senolytics or senomorphics may help mitigate these diseases. Animal studies provide mechanistic evidence for the connection between senescent cell accumulation and disease progression in various senopathies, including cardiovascular, metabolic, musculoskeletal, liver, kidney, lung diseases, and neurodegeneration. The development of novel senotherapies is hindered by the heterogeneity of senescence phenotypes, resulting in a lack of universal biomarkers and difficulties in distinguishing senescent from non-senescent cells.
Article
Engineering, Civil
Xiaohong Chen, Tianhao Li, Quan Yuan
Summary: This paper examines the travel behaviors and preferences of Generation Z using the latest data. The results indicate that Generation Z tends to choose environmentally friendly mode of transportation in response to changes in the built environment, showing their potential to support sustainable transportation.
Article
Chemistry, Physical
Jidong Chu, Zhijin Ge, Jiahui Peng, Hui Hu, Shujuan Guo, Xiaohui Chen
Summary: The study proposes a novel method, refluxing and implanting titanium, for synthesizing high catalytic performance MWW zeolite. By conducting titanium implantation under mild conditions, the preparation time is reduced. This method also explains the formation mechanism of the zeolite structure through density functional theory and achieves larger pore structure and improved catalytic performance through modified treatment.
Article
Cell Biology
Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Shi
Summary: This study found that ASD-like behaviors persist into late-middle age in Dock4 KO mice, with specific alterations in spatial memory and hippocampal anatomy by age.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Oncology
Shuwen Zhang, Jingjing Chen, Rui Zhang, Liqin Xu, Yan Wang, Zaixin Yuan, Xiaohui Hou, Jian Feng
Summary: PNETs are a group of highly heterogeneous tumors with different clinical manifestations, pathological features, and prognoses. Knowing clinicopathological characteristics and immunophenotypes of PNETs is significant for diagnosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Metallurgy & Metallurgical Engineering
Changyong Chen, Lu Wang, Meng Sun, Xiaoqing Chen, Yang Li, Zhouhua Jiang
Summary: This paper reviews the technical progress in the control of inclusions and central segregation in tyre cord steel wires and saw wire steel in the last 20 years and formulates the unresolved issues that should be studied in the next 10 years.
IRONMAKING & STEELMAKING
(2023)
Article
Cell Biology
Li Wang, Zhiwen Song, Hongjun Zou, Haining Chen, Yong Hu, Xiangnan Li, Jinbo Liu
Summary: The present study investigates the role of circRNA3616 in neuronal inflammation and apoptosis in spinal cord injury (SCI). The findings suggest that silencing of circRNA3616 can attenuate inflammation and apoptosis in SCI by inhibiting TLR4/NF-kappa B activity via sponging miR-137.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tao Yang, Shuren Zhang, Hao Yuan, Ying Wang, Linxiang Cai, Hanhua Chen, Xiaoyu Wang, Dongfan Song, Xiaohui Wang, Zijian Guo, Xiaoyong Wang
Summary: Triggering receptor expressed on myeloid cells-2 (TREM2) is a marker of tumor-infiltrating macrophages with immunosuppressive activity in the tumor microenvironment. The platinum(IV) complex OPA derived from oxaliplatin and artesunate has direct cytotoxicity against human colon cancer cells and inhibits TREM2 on macrophages in vitro and vivo. Furthermore, OPA reduces immunosuppressive macrophages and promotes the expansion and infiltration of immune-stimulating cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Surgery
Yao Liu, Nan Xia, Yuhe Duan, Xiongwei Wu, Chunyang Zhao, Chen Jin, Xue Chen, Qiang Gao, Yingming Wang, Feifei Wang, Fengjiao Wang, Yongjian Chen, Qian Dong, Xiwei Hao
Summary: This study investigated the clinical application of Computer-assisted Surgery system (CAS) in pediatric mediastinal tumor resection. The results showed that the CAS-assisted group had shorter operative duration, less intraoperative blood loss, shorter postoperative drain indwelling time, and shorter duration of hospitalization compared to the control group. However, there was no significant difference in the rate of blood transfusion and the incidence of postoperative complications between the two groups.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Article
Plant Sciences
Yongliang Hu, Yuqin Chen, Xiaoxia Su, Jiawei Huang, Hongxing Yin, Jie Zhang, Zhongkai Zhang, Yong Ding, Kuanyu Zheng
Summary: The present study characterized two potyviruses, wild tomato mosaic virus Dehong isolate (WTMV-Dh) and chilli veinal mottle virus Dehong isolate (ChiVMV-Dh), and assessed their mix-infection on chilli pepper. The complete genome sequences of both viruses were obtained using transcriptome next-generation sequencing technology and RT-PCR. Phylogenetic analysis revealed the relationship between these Dehong isolates and previously reported isolates of the same viruses. Mix-inoculation of these two viruses resulted in more severe symptoms compared to single-infection.
JOURNAL OF PHYTOPATHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiaoqing Chen, Yu Zhang, Ruijuan Tian, Xianghu Wu, Zhengdong Luo, Yan Liu, Xinran Wang, Jianlin Zhao, Xuetao Gan
Summary: A quadratically nonlinear photodetector (QNPD) composed of a van der Waals (vdW) stacked GaSe/InSe heterostructure is reported in this study. The QNPD exhibits unique electronic and optical attributes and extends the photodetection wavelength range from 900 to 1750 nm due to the extra second-harmonic generation (SHG) process in GaSe/InSe. It is highly sensitive to the variation of optical intensity and can be used as an autocorrelator for measuring ultrafast pulse widths and an optoelectronic mixer for signal processing.
Article
Management
Liang Wang, Zi-Xin Zhang, Alessio Ishizaka, Ying-Ming Wang, Luis Martinez
Summary: Many MCDS methods have been developed and applied to solve real-world problems. However, existing studies have neglected the psychological behavior of decision makers during the sorting process. This research proposes a new sorting method that considers psychological behavior and verifies its importance through country risk classification.
OMEGA-INTERNATIONAL JOURNAL OF MANAGEMENT SCIENCE
(2023)
Article
Engineering, Chemical
Shengyu Zhang, Shen Yan, Kangwei Lu, Shixuan Qiu, Xiao Dong Chen, Winston Duo Wu
Summary: Based on drug repositioning strategy, niclosamide has shown potential for treating COVID-19. However, developing effective NCL delivery formulations remains challenging. In this study, NCL-embedded dry powder for inhalation was fabricated using a novel spray freeze drying technology. By adjusting the composition and temperature, the size, morphology, crystal properties, flowability, and aerosol performance of the SFD microparticles were systematically investigated.
Article
Chemistry, Physical
Xiaoyan Chen, Rachel M. Johnson, Bo Li
Summary: Amide N-methylation is crucial for the activity and permeability of bioactive compounds. This study identifies the amide N-methyltransferase DtpM, which converts holomycin to thiolutin, expanding the examples of amide N-methyltransferases and potentially enabling the synthesis of diverse dithiolopyrrolone compounds for therapeutics.
Article
Computer Science, Artificial Intelligence
Liuqing Yang, Shoudong Wang, Xiaohong Chen, Wei Chen, Omar M. Saad, Xu Zhou, Nam Pham, Zhicheng Geng, Sergey Fomel, Yangkang Chen
Summary: This article proposes a deep learning model combining convolutional and recurrent networks for predicting reservoir permeability and porosity. By training a combination of nonlinear and linear modules, the mapping between logging data and reservoir parameters is established. Optimization algorithms and a self-attention mechanism are used to improve prediction accuracy. Testing on blind wells from different regions demonstrates the accuracy and robustness of the proposed method.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Milos Marinkovic, Olivia N. Tran, Hanzhou Wang, Parveez Abdul-Azees, David D. Dean, Xiao-Dong Chen, Chih-Ko Yeh
Summary: Salivary gland dysfunction can cause severe oral and systemic diseases and compromise quality of life. Current treatments are palliative, but transplantation of allogeneic cells and the use of mesenchymal stem cells (MSCs) show promising potential for restoring saliva production. However, recent findings suggest that allogeneic MSCs may not be immune-privileged after transplantation, whereas autologous MSCs could be a viable solution. Advances in in vitro expansion of autologous MSCs on tissue-specific matrices offer a new therapeutic approach for restoring SG function.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)