ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes

SGLT2 Inhibitors: Benefit/Risk Balance

(2016) André J. Scheen   Current Diabetes Reports

Oleanolic, Ursolic, and Betulinic Acids as Food Supplements or Pharmaceutical Agents for Type 2 Diabetes: Promise or Illusion?

(2016) Filomena S. G. Silva et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction

(2016) Chikara Komiya et al.   PLoS One

Exendin-4 attenuates adverse cardiac remodelling in streptozocin-induced diabetes via specific actions on infiltrating macrophages

(2015) Mitchel Tate et al.   BASIC RESEARCH IN CARDIOLOGY

The new esters derivatives of betulin and betulinic acid in epidermoid squamous carcinoma treatment – In vitro studies

(2015) Małgorzata Drąg-Zalesińska et al.   BIOMEDICINE & PHARMACOTHERAPY

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

(2015) Veronica De Rosa et al.   NATURE IMMUNOLOGY

The Economic Costs of Type 2 Diabetes: A Global Systematic Review

(2015) Till Seuring et al.   PHARMACOECONOMICS

Type 2 Diabetes Research Yield, 1951-2012: Bibliometrics Analysis and Density-Equalizing Mapping

(2015) Fiona Geaney et al.   PLoS One

Chemical genetics and its application to moonlighting in glycolytic enzymes

(2014) Da-Woon Jung et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone

(2014) Lars Verschuren et al.   BMC Medical Genomics

Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice

(2014) Bowen Lin et al.   Cardiovascular Diabetology

Chemical Targeting of GAPDH Moonlighting Function in Cancer Cells Reveals Its Role in Tubulin Regulation

(2014) Da-Woon Jung et al.   CHEMISTRY & BIOLOGY

Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice

(2014) Naoto Terami et al.   PLoS One

A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes

(2013) Da-Woon Jung et al.   ACS Chemical Biology

Histopathological Evaluation of Heart Toxicity of a Novel Selective PPAR-γ Agonists CKD-501 in db/db Mice

(2013) Hyun-Il Yang et al.   Biomolecules & Therapeutics

Negative transcriptional control of ERBB2 gene by MBP-1 and HDAC1: diagnostic implications in breast cancer

(2013) Flavia Contino et al.   BMC CANCER

Rosiglitazone Induces Cardiotoxicity by Accelerated Apoptosis

(2013) Pratibha Mishra et al.   Cardiovascular Toxicology

Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions

(2013) Tsutomu Wada et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SREBP: a novel therapeutic target

(2012) X. Xiao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

α-Enolase, a Multifunctional Protein: Its Role on Pathophysiological Situations

(2012) Àngels Díaz-Ramos et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model

(2011) Jian-Xiong Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Kidney: Its impact on glucose homeostasis and hormonal regulation

(2011) Asimina Mitrakou   DIABETES RESEARCH AND CLINICAL PRACTICE

Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet

(2011) Viviane Trak-Smayra et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional and Structural Changes in End-Stage Kidney Disease due to Glomerulonephritis Induced by the Recombinant α3(IV)NC1 Domain

(2010) Seiji NISHIBAYASHI et al.   EXPERIMENTAL ANIMALS

Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects

(2010) Da-Woon Jung et al.   Molecular BioSystems

Exendin-4 improves hepatocyte injury by decreasing proliferation through blocking NGF/TrkA in diabetic mice

(2010) Selda Gezginci-Oktayoglu et al.   PEPTIDES

The PPAR-γ agonist rosiglitazone facilitates Akt rephosphorylation and inhibits apoptosis in cardiomyocytes during hypoxia/reoxygenation

(2009) H. Kilter et al.   DIABETES OBESITY & METABOLISM

MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2

(2009) Kai-Wen Hsu et al.   MOLECULAR BIOLOGY OF THE CELL

Moonlighting proteins—an update

(2009) Constance J. Jeffery   Molecular BioSystems

Ang-1 Gene Therapy Inhibits Hypoxia-Inducible Factor-1  (HIF-1 )-Prolyl-4-Hydroxylase-2, Stabilizes HIF-1  Expression, and Normalizes Immature Vasculature in db/db Mice

(2008) J.-X. Chen et al.   DIABETES

The Activated Notch1 Receptor Cooperates with  -Enolase and MBP-1 in Modulating c-myc Activity

(2008) K.-W. Hsu et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptome Alteration in the Diabetic Heart by Rosiglitazone: Implications for Cardiovascular Mortality

(2008) Kitchener D. Wilson et al.   PLoS One

Rosiglitazone: Possible complications and treatment of non-alcoholic steatohepatitis (NASH)

(2007) Jens H. Henriksen et al.   JOURNAL OF HEPATOLOGY