Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
出版年份 2017 全文链接
标题
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
作者
关键词
-
出版物
Scientific Reports
Volume 7, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-01-30
DOI
10.1038/srep37716
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- (2015) C. S. Milagre et al. CANCER RESEARCH
- Alternative modulation of protein–protein interactions by small molecules
- (2015) Gerhard Fischer et al. CURRENT OPINION IN BIOTECHNOLOGY
- IL-6 as a keystone cytokine in health and disease
- (2015) Christopher A Hunter et al. NATURE IMMUNOLOGY
- A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen
- (2015) A. Impagliazzo et al. SCIENCE
- Discovery and characterization of olokizumab
- (2014) Stevan Shaw et al. mAbs
- IL-6 biology: implications for clinical targeting in rheumatic disease
- (2014) Leonard H. Calabrese et al. Nature Reviews Rheumatology
- Can emerging drug classes improve R&D productivity?
- (2013) Christoph Meier et al. DRUG DISCOVERY TODAY
- STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
- (2013) Y. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
- (2012) Stefan Rose-John International Journal of Biological Sciences
- Conservation of Functional Sites on Interleukin-6 and Implications for Evolution of Signaling Complex Assembly and Therapeutic Intervention
- (2012) Vaclav Veverka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cytokine Response Is Determined by Duration of Receptor and Signal Transducers and Activators of Transcription 3 (STAT3) Activation
- (2012) David A. Braun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Label-free epitope binning assays of monoclonal antibodies enable the identification of antigen heterogeneity
- (2012) Yasmina N. Abdiche et al. JOURNAL OF IMMUNOLOGICAL METHODS
- The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation
- (2012) Daniel Lightwood et al. JOURNAL OF MOLECULAR BIOLOGY
- Antibody-enabled small-molecule drug discovery
- (2012) Alastair D. G. Lawson NATURE REVIEWS DRUG DISCOVERY
- Structural biology and drug discovery for protein–protein interactions
- (2012) Harry Jubb et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Molecular Interaction Studies Using Microscale Thermophoresis
- (2011) Moran Jerabek-Willemsen et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- IL-6/IL-6 receptor system and its role in physiological and pathological conditions
- (2011) Masahiko Mihara et al. CLINICAL SCIENCE
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Hydrogen exchange mass spectrometry for studying protein structure and dynamics
- (2010) Lars Konermann et al. CHEMICAL SOCIETY REVIEWS
- Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
- (2010) Ron Diskin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Cytokine-dependent activation of small hepatocyte-like progenitor cells in retrorsine-induced rat liver injury
- (2009) D. Hunter Best et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
- (2008) Jeffrey E. Lee et al. NATURE
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