Article
Biochemistry & Molecular Biology
Davide Moi, Serena Vittorio, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran, Valentina Onnis
Summary: A series of hydrazonobenzenesulfonamides were designed, synthesized and evaluated for their inhibitory activity against human carbonic anhydrase (hCA) isoforms. The synthesized compounds showed inhibitory activity at low nanomolar levels against hCA I, II, IX and XII, with selectivity against hCA II isoform, as well as hCA IX and XII isoforms. Docking studies were conducted to understand the activity and selectivity of the most potent and selective hydrazones towards different CA isoforms.
Article
Biochemistry & Molecular Biology
Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran, Raivis Zalubovskis
Summary: A series of novel compounds were synthesized and evaluated for their inhibition of eukaryotic and human carbonic anhydrases. The results showed good inhibition against some target enzymes and weaker inhibition against others. These findings are important for the search for potential antifungal drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Mehtap Tugrak, Halise Inci Gul, Yeliz Demir, Ilhami Gulcin
Summary: A series of novel compounds with potential and selective inhibitory effects on human carbonic anhydrase I and II were synthesized, demonstrating promise as candidate drugs for treating glaucoma. Some compounds showed significant inhibitory effects against the target proteins, highlighting their potential for further investigation as lead compounds in alleviating glaucoma symptoms.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Medicinal
Silvia Salerno, Giorgio Amendola, Andrea Angeli, Emma Baglini, Elisabetta Barresi, Anna Maria Marini, Rahul Ravichandran, Monica Viviano, Sabrina Castellano, Ettore Novellino, Federico Da Settimo, Claudiu T. Supuran, Sandro Cosconati, Sabrina Taliani
Summary: Carbonic Anhydrases (CAs) are important targets for treating various disease conditions, but the difficulty lies in finding potential drugs due to their ubiquitous localization and high homology. By synthesizing new bicyclic tetrahydroindazoles and conducting biological evaluations and theoretical studies, a new platform for the discovery of isotype selective CA inhibitors has been identified.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Niccolo Chiaramonte, Andrea Angeli, Silvia Sgambellone, Alessandro Bonardi, Alessio Nocentini, Gianluca Bartolucci, Laura Braconi, Silvia Dei, Laura Lucarini, Elisabetta Teodori, Paola Gratteri, Bernhard Wuensch, Claudiu T. Supuran, Maria Novella Romanelli
Summary: Targeting carbonic anhydrases is a strategy for treating various diseases. In this study, a new series of chiral piperazine compounds was synthesized to widen the structure-activity relationships of potent human carbonic anhydrase inhibitors. Some of the synthesized compounds showed high inhibitory activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Nashwa H. Zaher, Reham M. M. Elhazek, Ahmed E. Gouda, Amira Khalil, Marwa G. Elgazzar
Summary: Eleven novel sulfonamide-pyridine hybrids were designed, synthesized, and evaluated for their potential use in targeting breast cancer. Compound 7 showed the highest cytotoxic activity against three breast cancer cell lines and also induced cell cycle arrest, autophagy, and delayed wound healing. Furthermore, compound 7 exhibited a notable IC50 value against carbonic anhydrase IX. The study encourages further exploration of sulfonamide derivatives for their structure-activity relationships.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Viviana De Luca, Simone Giovannuzzi, Claudiu T. Supuran, Clemente Capasso
Summary: Blocking bacterial carbonic anhydrases can reduce pathogen survival and fitness. The recombinant M. sciuri gamma-CA showed significant hydratase activity, with a sulfonamide inhibitory profile different from that of MscCA beta, suggesting the possibility of developing novel CA class-specific inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Ali Bahadur, Shahid Iqbal, Saiqa Muneer, Hashem O. Alsaab, Nasser S. Awwad, Hala A. Ibrahium
Summary: The study synthesized sulfonamide-based thiadiazole derivatives (STDs) and investigated their potentials in carbonic anhydrase inhibition and anticancer activity. The results showed that one of the STDs, STD 4f, exhibited the best inhibition activity against carbonic anhydrase. Additionally, the STDs also demonstrated strong anticancer properties, which were mainly achieved through carbonic anhydrase inhibition.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Andrea Angeli, Niccolo Paoletti, Claudiu T. Supuran
Summary: The development of heterocyclic derivatives, particularly five-membered heterocyclic sulfonamides, as carbonic anhydrase inhibitors (CAIs) has been significant in the field of medicinal chemistry. Oxygen and nitrogen five-membered heterocyclic aromatic rings are important, but the installation of sulfonamide moiety on such heterocycles has not been widely studied. On the other hand, 1,3,4-thiadiazole/thiadiazoline ring-bearing sulfonamides have been extensively used in a variety of pharmaceutically important CAIs. This review focuses on the diverse biological activities and pharmacological/clinical applications of these CAIs.
Article
Chemistry, Physical
Serdar Burmaoglu, Elif Akin Kazancioglu, Mustafa Z. Kazancioglu, Ruya Saglamtas, Gozde Yalcin, Ilhami Gulcin, Oztekin Algul
Summary: This study synthesized new biphenyl-substituted chalcone derivatives and evaluated their inhibitory activity against various enzymes. The results showed that these derivatives exhibited effective inhibition against the enzymes and have potential for the development of new drugs for the treatment of diverse diseases.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Medicinal
Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. T. Supuran, Raivis Zalubovskis
Summary: Two novel sulfaguanidine series were synthesized by desulfidative amination of dimethyl arylsulfonylcarbonimidodithioates. These compounds were tested for their inhibition of human carbonic anhydrase isozymes. The N-(N-alkyl/benzyl-carbamimidoyl) benzenesulfonamide derivatives showed higher inhibitory activity than the N-(N,N'-dialkyl/dibenzyl-carbamimidoyl) benzenesulfonamide derivatives.
Article
Chemistry, Medicinal
Busra O. Aydin, Derya Anil, Yeliz Demir
Summary: In this study, new derivatives of pyrazolo[3,4-d]pyrimidine were synthesized by alkylating the N1 nitrogen atom. These compounds showed a broad spectrum of biological activity. The synthesis involved a series of steps to generate N-alkylated pyrazolo[3,4-d]pyrimidine derivatives, which were then tested for their ability to inhibit AChE and hCA isoforms. Among them, compound 10 exhibited the highest selectivity and potency as a CA I inhibitor.
ARCHIV DER PHARMAZIE
(2021)
Review
Chemistry, Medicinal
Shubham Kumar, Sandeep Rulhania, Shalini Jaswal, Vikramdeep Monga
Summary: Carbonic anhydrase is an important enzyme involved in various physiological and pathological processes, with 16 different isoforms in humans. Inhibitors targeting different isoforms of carbonic anhydrase have clinical applications in treating various diseases, but current drugs lack selectivity leading to undesired side effects. Efforts are being made to develop novel isoform-selective inhibitors of carbonic anhydrase for therapeutic implications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Dounia Elfadil, Sara Palmieri, Flavio Della Pelle, Manuel Sergi, Aziz Amine, Dario Compagnone
Summary: This study presents a novel method combining molecularly imprinted polymers (MIPs) and enzymatic inhibition assay for the selective and sensitive determination of acetazolamide (ACZ) in biological samples. The MIPs were synthesized using ACZ as the template molecule and were used as the sorbent phase in dispersive solid-phase extraction (MIPs-dSPE). The developed method showed good recovery and correlation with LC-MS/MS analysis, providing a selective and quantitative approach for the determination of ACZ.
Article
Biochemistry & Molecular Biology
Morteza Abdoli, Alessandro Bonardi, Niccolo Paoletti, Ashok Aspatwar, Seppo Parkkila, Paola Gratteri, Claudiu T. Supuran, Raivis Zalubovskis
Summary: A library of structurally diverse N-((4-sulfamoylphenyl)carbamothioyl) amides was synthesized by selectively acylating 4-thioureidobenzenesulfonamide with various acyl chlorides. The inhibitory effects of these sulfonamides on human carbonic anhydrase (hCA) and bacterial beta-carbonic anhydrase from Mycobacterium tuberculosis (MtCA) were investigated in vitro and in silico. The compounds showed better inhibition against hCA I, hCA II, hCA VII, as well as MtCA1 and MtCA2, but poor inhibition against MtCA3.
Article
Biochemistry & Molecular Biology
Armagan Gunsel, Bilge Yazar, Parham Taslimi, Yavuz Erden, Tugba Taskin-Tok, Hasan Piskin, Ahmet T. Bilgicli, M. Nilufer Yarasir, Ilhami Gulcin
Summary: In this study, a novel starting material was synthesized and its structure was verified. Several new phthalocyanine compounds were synthesized and characterized using various spectroscopic methods. These compounds showed inhibitory effects on acetylcholinesterase and alpha-glycosidase enzymes, and exhibited normal cytotoxic effects on cancer cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Zubeyda Israfilova, Parham Taslimi, Ilhami Gulcin, Yusif Abdullayev, Vagif Farzaliyev, Muhammet Karaman, Afsun Sujayev, Saleh H. Alwasel
Summary: This study focuses on the synthesis of thiocyanate-containing heterocyclic compounds and determines their inhibitory abilities against various enzymes. Theoretical calculations reveal the mechanism of substituting chloride with thiocyanate in aziridine derivatives. The synthesized compounds show potent inhibitory abilities and specifically inhibit hCA I and hCA II enzymes.
Article
Biology
Muzaffer Mutlu, Zeynebe Bingol, Eda Mehtap Uc, Ekrem Koksal, Ahmet C. Goren, Saleh H. Alwasel, Ilhami Gulcin
Summary: This study evaluated the antioxidant and antidiabetic properties of cinnamon leaf essential oil and determined its inhibitory effects on enzymes associated with metabolic diseases. Phenolic contents and essential oil profiles were analyzed. Cinnamon oil showed strong radical scavenging abilities and effectively inhibited carbonic anhydrase II, acetylcholinesterase, and alpha-amylase. This multidisciplinary study is valuable for further research on antioxidant properties and enzyme inhibition profiles of important plants and their oils.
Article
Chemistry, Inorganic & Nuclear
Ramazan Zengin, Yetkin Gok, Yeliz Demir, Betul Sen, Tugba Taskin-Tok, Aydin Aktas, Ozlem Demirci, Ilhami Gulcin, Muhittin Aygun
Summary: In this study, a series of symmetric and unsymmetric N-heterocyclic carbene (NHC) precursors based on benzimidazol-2-ylidene were synthesized and their structures were characterized. The enzyme inhibition activities of these compounds against acetylcholinesterase (AChE) and carbonic anhydrases (hCAs) were investigated, showing potent inhibitory effects. These results have potential implications for the development of new drug candidates for the treatment of Alzheimer's disease and glaucoma.
JOURNAL OF FLUORINE CHEMISTRY
(2023)
Article
Chemistry, Physical
Zafer Bulut, Nurgul Abul, Ayse Halic Poslu, Ilhami Gulcin, Abdulilah Ece, Erol Ercag, Omer Koz, Gamze Koz
Summary: A series of novel uracil-appended benzylic amines were synthesized through reductive amination with moderate to good yields (30-84% yields). The compounds were characterized using FT-IR, H-1 NMR, C-13 NMR spectroscopy and elemental analysis. The inhibition abilities of the compounds were evaluated against acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and II) isoenzymes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Nawrooz Ali Zahedi, Maryam Mohammadi-Khanaposhtani, Parisa Rezaei, Mohammad Askarzadeh, Majid Alikhani, Mehdi Adib, Mohammad Mahdavi, Bagher Larijani, Somayeh Niakan, Maliheh Barazandeh Tehrani, Parham Taslimi, Ilhami Gulcin
Summary: Alzheimer's disease (AD) is a complex and progressive cognitive disorder. Cholinesterase (ChE) inhibitors have been proven to be effective in treating AD, and recent studies have shown that inhibiting human carbonic anhydrases (hCAs) can also aid in AD treatment. New coumarindihydropyridine derivatives (6a-m) were designed to combine potent ChE and hCA inhibitory effects. These compounds were evaluated and showed promising results against AChE, BChE, and hCAs. In silico screening using Autodock software and preADMET online software further confirmed their potential therapeutic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Mehmet Koca, Ilhami Gulcin, Eda Mehtap Uc, Sinan Bilginer, Amine Sena Aydin
Summary: In this study, a hybrid molecule consisting of salicylic acid and salicyl amide structures was synthesized and five new amide derivatives were synthesized for the first time. Their antioxidant potentials were evaluated through various assays, and their potential as drug candidates for Alzheimer's disease was investigated through AChE inhibition studies.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Medicinal
Halil Senol, Gurbet Celik Turgut, Alaattin Sen, Rueya Saglamtas, Salih Tuncay, Ilhami Gulcin, Guelacti Topcu
Summary: In this study, a series of compounds were synthesized from oleanolic acid (OA), including five new compounds (10, 11, 12, 15 and 17) as oxime, imine and hydrazone derivatives. NMR and HRMS analyses were conducted to determine their structures. The inhibitory effects of these compounds on acetylcholinesterase (AChE), human carbonic anhydrase I (hCA I) and II (hCA II) were evaluated. Compounds 13 and 15 exhibited significant inhibitory activity against both hCA I and hCA II, with compound 15 also showing the strongest AChE inhibitory activity.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hasan Karagecili, Mustafa Abdullah Yilmaz, Adem Erturk, Hatice Kiziltas, Leyla Guven, Saleh H. Alwasel, Ilhami Gulcin
Summary: This study investigated the chemical composition and antioxidant activities of propolis, finding that it is rich in phenolic and flavonoid compounds with antioxidant, antimicrobial, and anticancer properties. Propolis extract also exhibited inhibitory activities against enzymes associated with diabetes, Alzheimer's disease, and glaucoma. Additionally, twenty-eight phenolic compounds were determined to be major organic compounds in propolis, making it a potential natural product for the treatment of various diseases.
Article
Chemistry, Medicinal
Leyla Guven, Adem Erturk, Fatma Demirkaya Miloglu, Saleh Alwasel, Ilhami Gulcin
Summary: In this study, we evaluated the in vitro antiglaucoma, antidiabetic, anti-Alzheimer's disease, and antioxidant activities of the methanolic and water extracts of Astragalus alopecurus. The extracts showed inhibition ability on various enzymes and exhibited antioxidant properties. These findings provide a foundation for further exploring the therapeutic potential of Astragalus species.
Article
Biology
Hasan Karagecili, Ebubekir Izol, Ekrem Kirecci, Ilhami Gulcin
Summary: Zivzik pomegranate (Punica granatum) has gained interest recently for its nutritional and antioxidant properties. The antioxidant capacities of different extracts from peel and seed were evaluated using several methods, and compared with commonly used synthetic antioxidants. The extracts showed lower IC50 values for scavenging activities and exhibited inhibitory effects on various enzymes. LC-MS/MS analysis identified multiple phenolic compounds. Additionally, the bacteria E. coli and S. aureus showed resistance to standard antibiotics.
Article
Biochemistry & Molecular Biology
Songul Cakmakci, Ilhami Gulcin, Engin Gundogdu, Hatice Ertem Oztekin, Parham Taslimi
Summary: Oxidation is a significant factor impacting the shelf life and quality of food. Plant-derived antioxidants, such as green tea powder, have been studied for their health benefits and use in food. This study compares the antioxidant effects of green tea powder with commercial antioxidants in butter and evaluates their impact on various properties.
Article
Biology
Eda Mehtap Ozden, Zeynebe Bingol, Muzaffer Mutlu, Hasan Karagecili, Ekrem Koksal, Ahmet C. Goren, Saleh H. Alwasel, Ilhami Gulcin
Summary: This research comprehensively examined and researched the kiwifruit oil using various bioanalytical methods, determining its antioxidant, antiglaucoma, antidiabetic, and anti-Alzheimer's capabilities. The inhibitory effects on several enzymes linked to metabolic illnesses were also established. The chemical composition and quantity of essential oils contained in kiwifruit oil were studied. The results demonstrated the potent radical scavenging properties and inhibition effects on enzymes of kiwifruit oil, suggesting its significant potential in pharmaceutical procedures.
Article
Biochemistry & Molecular Biology
Alper Yildirim, Ufuk Atmaca, Ertan Sahin, Parham Taslimi, Tugba Taskin-Tok, Murat Celik, Ilhami Gulcin
Summary: This article examines the use of oxazolidinones in various applications such as antibiotics and protein synthesis inhibition. The synthesized compounds were found to have potent inhibitory effects on enzymes such as acetylcholinesterase and carbonic anhydrase. Molecular docking and ADMET analysis were conducted to correlate the experimental data.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Erkan Oner, Yetkin Gok, Yeliz Demir, Tugba Taskin-Tok, Aydin Aktas, Ilhami Gulcin, Serap Yalin
Summary: This study presents the synthesis and characterization of a series of benzimidazolium salts, and investigates their enzyme inhibition abilities against acetylcholinesterase and carbonic anhydrase. The results show that these salts have potent inhibition effects. The pharmacokinetic properties of the compounds were also predicted.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Wafa A. Bawazir, Maymoona A. Al-Mahmood, Rawan S. Almalki, Ghadi F. Alofi, Raghad S. Alharbi, Zoya Zaheer
Summary: This study investigates the interaction between sulfathiazole and three types of surfactants using UV-visible spectroscopy and conductivity measurements. The results show that the critical micelle concentration of cationic and anionic surfactants decreases with increasing sulfathiazole concentration, while the interaction with non-ionic surfactant is weak.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Musaad K. Aleid, Khalid N. Alharbi, Mona A. Aljufareen, Areej S. Aloliwi, Alhanouf K. Almutairi, Rahaf S. Alsaif, Nada K. Alshayeb, Mohammed S. Almoiqli
Summary: This study assessed the levels of trihalomethane compounds in the water network of Riyadh city and identified the factors influencing their formation. The concentrations of trihalomethane compounds were within the permissible limits, indicating the water's safety for human consumption. The presence of bromide ions, organic carbon, free chlorine, and pH values were found to affect trihalomethane formation.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Said Arhzaf, Jamal Houssaini, Mohammed Naciri Bennani, Marwa Alaqarbeh, Mohammed Bouachrine
Summary: The study shows that Mg-Al hydrotalcite catalysts intercalated with acetate and carbonate anions exhibit superior catalytic activity in the aldol condensation reaction between furfural and acetone. The optimal reaction conditions are at 90 degrees C for 2 hours, achieving conversion rates of over 98% with high selectivity towards F2A for the acetate catalyst.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Uyen-Chi Nguyen Le, Ngoc Xuan Dat Mai, Kieu-Minh Le, Hoang Anh Vu, Huynh-Nhu Thi Tran, Tan Le Hoang Doan
Summary: This study aimed to enhance the bioavailability of rosmarinic acid, a bioactive compound with high anticancer activity, by encapsulating it in tetrasulfide-based porous organosilica nanoparticles. The synthesized nanoparticles were small in size and had a high surface area and an average pore diameter. The nanoparticles showed effective accumulation in cancer cells without toxicity to normal cells. Treatment with rosmarinic acid-containing nanoparticles resulted in significant cell death in cancer cells. Overall, these findings suggest that the synthesized nanoparticles can enhance the pharmacological effects of rosmarinic acid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jiamin Qi, Hengxi Zhu, Tianyu Yang, Xingyuan Wang, Zixuan Wang, Xiaoli Lei, Bin Li, Wenmin Qian
Summary: This study synthesized a novel iron-biochar adsorbent using the iron content in red mud to remove heavy metals from wastewater. The adsorbent showed excellent removal efficiency and sustainability. This method addresses both industrial waste recovery and heavy metal adsorption issues.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Bo Yi, Li Zhang, Haiyang Zhou
Summary: Plasma protein binding plays a crucial role in the pharmacokinetics and pharmacodynamics of therapeutic bioactive materials. In this study, the interaction of nordentatin, a member of coumarins, with human alpha-1 acid glycoprotein (AGP) was investigated, and the anticancer potency of nordentatin against human colorectal cancer cells was evaluated. The results showed that nordentatin binds to AGP through a static quenching mechanism and exhibits inhibitory effects on the growth of HCT-116 cells by increasing intracellular ROS and [Ca2+] levels and triggering apoptosis-related gene overexpression. Therefore, nordentatin could be a promising plant-based therapy for colorectal cancer.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T. H. Wu, Hsu-Shan Huang
Summary: Tetraheterocyclic compounds derived from natural sources and contemporary pharmaceuticals have shown promise as multitarget therapeutic agents. In this study, a series of synthesized compounds were evaluated for their potential in breast cancer treatment. Compounds 18 and 20 demonstrated significant antiproliferative activity against breast cancer cell lines and their mode of action was revealed through molecular docking simulations.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Mohammad Khosravani, Mohsen Dehghani Ghanatghestani, Farid Moeinpour, Hossein Parvaresh
Summary: The aim of removing Pb(II) from water is to minimize the potential harm posed by toxic metals to both human health and the environment. A covalent organic framework adsorbent called TFPOTDB-SO3H was developed with excellent properties such as high repeatability, selectivity, and easy solid-liquid separation. The adsorbent showed impressive capability of adsorbing Pb(II) and effective removal of it from a solution with various ions, suggesting its potential for effectively adsorbing and removing Pb(II) heavy metal ions from wastewater.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Ashraf H. Farha, Mohamed S. Shams, Hasna A. Alali, Zakia H. Alhashem, Shehab A. Mansour, Shrouq H. Aleithan, Ragab A. Elsad
Summary: The current study examines the dielectric and thermal properties of transformer oil incorporated with Mn0.5 Zn0.5 Fe2O4 nanoparticles. The results show that the addition of Mn-Zn ferrite NPs improves the dielectric constant, dissipation factor, AC breakdown voltage, and convective heat transfer of the nanofluid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Limin Hou, Zongpei Jiang, Minqi Ye, Xueyan Sun, Kexin Liu, Yifan Zhu, Xiaoyu Wang, Liangzhu Chen, Ruiheng Gu, Binghu Fang
Summary: The excessive accumulation of antibiotic residue in animal-derived foods poses a threat to health. Therefore, it is necessary to establish a rapid, simple, effective, safe, and highly sensitive method for detecting lincomycin residues. By using a pre-column derivatization method on high-performance liquid chromatography equipped with ultraviolet, the UV absorption of lincomycin is improved, allowing for detection and quantification.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Kun Tang, Xin-Xin Wang, Jin-Jin Zhao, Ning Ren, Jian-Jun Zhang
Summary: This study reports the synthesis, crystal structures, and thermal degradation properties of three new rare earth coordination compounds. Compounds 1-3 exhibit binuclear structures which can form chain-like structures via hydrogen bonding. Compound 2 shows potential application value in the orange-red luminescence region.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Seoyoun Yang, Eunbi Yu, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Su Bin Han, Soo Hyun Kang, Jung Hyun Lee, Heejun Ha, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: This study investigated the effects of blue light on the hypodermis and found that it has antiadipogenic properties by reducing lipid accumulation and downregulating the expression of adipogenic genes. Blue light also increased the phosphorylation of PPAR gamma and TRPV1, suggesting its anti-adipogenic effect through these signaling pathways.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Abdul Nasir, Abdul Waheed Khan, Hamid Rafiq Khattak, Abdus Samad, Sami Ullah, Haroon Khan, Muhammad Faheem, Qian Bai
Summary: This study evaluated the effects of isoxazolone derivatives on cisplatin-induced neuropathy in a rat model. The results showed that isoxazolone derivatives effectively reversed mechanical allodynia, similar to the known therapeutic agent pregabalin. Molecular docking analysis indicated that isoxazolone derivatives have strong binding affinity for relevant receptors and potential inhibitory activity against relevant signaling pathways. This study has innovative implications for the treatment of cisplatin-induced neuropathic pain.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Shahid Wahab, Haroon Muhammad Ali, Maham Khan, Tariq Khan, Chandran Krishnaraj, Soon-Il Yun
Summary: In this study, we synthesized chitosan nanoparticles, silver nanoparticles, and chitosan/silver nanocomposites using aqueous ginger extract as a green approach. These nanomaterials showed significant antibacterial properties and low toxicity. Furthermore, the nanomaterials conjugated with tobramycin demonstrated enhanced antibacterial efficacy and exhibited interactions with Pseudomonas aeruginosa.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
