Article
Chemistry, Medicinal
Leyla Guven, Adem Erturk, Fatma Demirkaya Miloglu, Saleh Alwasel, Ilhami Gulcin
Summary: In this study, we evaluated the in vitro antiglaucoma, antidiabetic, anti-Alzheimer's disease, and antioxidant activities of the methanolic and water extracts of Astragalus alopecurus. The extracts showed inhibition ability on various enzymes and exhibited antioxidant properties. These findings provide a foundation for further exploring the therapeutic potential of Astragalus species.
Article
Chemistry, Applied
Uri Yaritz, Ron Schweitzer, Doron Holland, Li Tian, Rachel Amir
Summary: Pomegranate fruit peels are rich in phenolic metabolites, which play an important role in the nutritional value and protection of pomegranate juice. There are variations in phenolic metabolites among different pomegranate accessions, and these metabolites may have competitive and coordinated regulatory relationships with each other.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Review
Chemistry, Applied
Zainaipuguli Yisimayili, Zhi Chao
Summary: This review provides a comprehensive overview of research on different parts of pomegranate, including phytochemicals, metabolism, and pharmacokinetics studies. The review also introduces analysis strategies for identifying compounds and metabolites and speculates the structures and constitutional isomers of ellagitannins and gallotannins.
Article
Plant Sciences
Hazem S. Elshafie, Lucia Caputo, Laura De Martino, Shimaa H. Sakr, Vincenzo De Feo, Ippolito Camele
Summary: The study demonstrated that pomegranate exocarp extract shows promising antifungal and antibacterial activities, suggesting its potential as a food preservative and substitute for controlling plant pathogens. Additionally, the extract also exhibited antioxidant and acetylcholinesterase inhibitory effects.
Article
Biochemistry & Molecular Biology
Emine O. Karaca, Zeynebe Bingol, Nevin Gurbuz, Ismail Ozdemir, Ilhami Gulcin
Summary: A series of vinyl functionalized 5,6-dimethylbenzimidazolium salts were synthesized and evaluated for their inhibition ability against various enzymes. The compounds showed effective inhibition profiles and may contribute to the development of new drugs for global disorders.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Food Science & Technology
M. J. Gomez-Bellot, C. J. Garcia, A. Parra, F. Vallejo, M. F. Ortuno
Summary: Water deficit is a critical factor that affects agricultural productivity. This study used LC-MS-based untargeted metabolomics approach to investigate the impact of irrigation levels on bioactive compounds in a commercial pomegranate cultivar. The results showed that pomegranate juices from plants grown under water deficit conditions exhibited increased levels of bioactive compounds compared to the control group.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lokman Durmaz, Hatice Kiziltas, Hasan Karagecili, Saleh Alwasel, Lhami Gulcin
Summary: The study found that spiraeoside in onions has antioxidant and enzyme inhibition abilities, which may have potential as a medicine for diseases such as Alzheimer's disease, diabetes, and glaucoma.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Chemistry, Medicinal
Busra O. Aydin, Derya Anil, Yeliz Demir
Summary: In this study, new derivatives of pyrazolo[3,4-d]pyrimidine were synthesized by alkylating the N1 nitrogen atom. These compounds showed a broad spectrum of biological activity. The synthesis involved a series of steps to generate N-alkylated pyrazolo[3,4-d]pyrimidine derivatives, which were then tested for their ability to inhibit AChE and hCA isoforms. Among them, compound 10 exhibited the highest selectivity and potency as a CA I inhibitor.
ARCHIV DER PHARMAZIE
(2021)
Review
Food Science & Technology
Alami Mehdi, Benchagra Lamiae, Boulbaroud Samira, Mhamed Ramchoun, Khalil Abdelouahed, Fulop Tamas, Berrougui Hicham
Summary: Polyphenols have neuroprotective benefits and could be valuable in treating neurodegenerative diseases like Alzheimer's and Parkinson's. However, inconsistent findings and variations in individuals and study designs need to be considered.
Article
Agriculture, Multidisciplinary
Jing-Hui Ruan, Jun Li, Guliqire Adili, Guang-Ying Sun, Munire Abuduaini, Rahima Abdulla, Maitinuer Maiwulanjiang, Haji Akber Aisa
Summary: A study found that compounds extracted from pomegranate peels have potential biological activities, including antioxidant, antimicrobial, and antitumor activities. These findings provide further information on the utilization of pomegranate peels.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Applied
Yingying Li, Yingying Zhang, Chaodi Kang, Wentao Zhao, Shilei Li, Shouwei Wang
Summary: Food fraud is a global issue that has raised wide public concern in recent years. Mass spectrometry techniques have a significant advantage in analyzing food authenticity. A simple, specific, and fast LC-MS/MS method has been developed to quantitatively determine pork content in processed meat products.
Article
Chemistry, Multidisciplinary
Ufuk Atmaca, Ruya Saglamtas, Yusuf Sert, Murat Celik, Ilhami Gulcin
Summary: This article reports a highly effective one-pot synthesis of novel isoindolinones through intramolecular cyclization of various 2-benzoylbenzoic acid derivatives in mild conditions in the absence of a metal catalyst, using chlorosulfonyl isocyanate as the catalyst. The newly synthesized compounds were tested against metabolic enzymes associated with Alzheimer's disease, type-2 diabetes mellitus, epilepsy, and glaucoma. The novel isoindolinones showed potent inhibition ability against AChE, BChE, alpha-glycosidase, hCA I, and hCA II enzymes.
Article
Biochemistry & Molecular Biology
Rifat Emin Bora, Hayriye Genc Bilgicli, Eda Mehtap Uc, Mehmet Abdullah Alagoz, Mustafa Zengin, Ilhami Gulcin
Summary: Eight new aminothiols and three new sulfonic acid derivatives were synthesized and evaluated for their inhibitory effects on various enzymes. The results showed that these newly synthesized compounds exhibited significant inhibitory activity against carbonic anhydrase and cholinesterase, making them potential candidates for the treatment of glaucoma and Alzheimer's disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Hasan Karagecili, Mustafa Abdullah Yilmaz, Adem Erturk, Hatice Kiziltas, Leyla Guven, Saleh H. Alwasel, Ilhami Gulcin
Summary: This study investigated the chemical composition and antioxidant activities of propolis, finding that it is rich in phenolic and flavonoid compounds with antioxidant, antimicrobial, and anticancer properties. Propolis extract also exhibited inhibitory activities against enzymes associated with diabetes, Alzheimer's disease, and glaucoma. Additionally, twenty-eight phenolic compounds were determined to be major organic compounds in propolis, making it a potential natural product for the treatment of various diseases.
Article
Chemistry, Physical
Serdar Burmaoglu, Elif Akin Kazancioglu, Mustafa Z. Kazancioglu, Ruya Saglamtas, Gozde Yalcin, Ilhami Gulcin, Oztekin Algul
Summary: This study synthesized new biphenyl-substituted chalcone derivatives and evaluated their inhibitory activity against various enzymes. The results showed that these derivatives exhibited effective inhibition against the enzymes and have potential for the development of new drugs for the treatment of diverse diseases.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Mustafa Abdullah Yilmaz, Parham Taslimi, Omer Kilic, Ilhami Gulcin, Abhijit Dey, Ercan Bursal
Summary: This ethnobotanical study investigated the chemical constituents and pharmacological activities of Achillea pseudoaleppica. The ethanol and water extracts of A. pseudoaleppica exhibited strong antioxidant properties and inhibited several enzymes. Quinic acid was identified as the most abundant phenolic compound in the extracts. The findings suggest that A. pseudoaleppica has potential therapeutic applications due to its rich phenolic content and pharmacological properties.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Mahmut O. Karaytug, Neslihan Balci, Fikret Turkan, Mahmut Gurbuz, Mehmet E. Demirkol, Zeynep Namli, Lut Tamam, Ilhami Gulcin
Summary: Cholinesterases and glutathione S-transferases (GSTs) play crucial roles in the biochemical processes of the nervous system and detoxification in the human body. Piperazine derivatives show potential therapeutic effects in neurological disorders and cancer research.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emine O. Karaca, Zeynebe Bingol, Nevin Gurbuz, Ismail Ozdemir, Ilhami Gulcin
Summary: A series of vinyl functionalized 5,6-dimethylbenzimidazolium salts were synthesized and evaluated for their inhibition ability against various enzymes. The compounds showed effective inhibition profiles and may contribute to the development of new drugs for global disorders.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ozlem Demirci, Burcu Tezcan, Yeliz Demir, Tugba Taskin-Tok, Yetkin Gok, Aydin Aktas, Bilgehan Guzel, Ilhami Gulcin
Summary: In this study, we synthesized thirteen new 1-(4-acetylphenyl)-3-alkylimidazolium salts and investigated their inhibition activities against AChE and hCAs. The synthesized compounds showed highly potent inhibition effects, with most of them outperforming the standard inhibitors.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Medicinal
Haleh Hamedifar, Maryam Mohammadi-Khanaposhtani, Maedeh Sherafati, Milad Noori, Ali Moazam, Samanesadat Hosseini, Bagher Larijani, Mir H. Hajimiri, Mohammad Mahdavi, Mehmet K. Erdogan, Ramazan Gundogdu, Mahinur Kirici, Parham Taslimi, Ilhami Gulcin
Summary: A new series of indole-carbohydrazide-phenoxy-N-phenylacetamide derivatives 7a-l were synthesized and evaluated for their alpha-glucosidase inhibitory abilities and cytotoxic effects. Most of the synthesized derivatives showed good to moderate inhibitory abilities against alpha-glucosidase. Among them, 2-methoxy-phenoxy derivatives 7l and 7h exhibited the highest inhibition effects. Compound 7k showed moderate cytotoxicity against a lung cancer cell line.
ARCHIV DER PHARMAZIE
(2023)
Article
Biochemistry & Molecular Biology
Yetkin Gok, Parham Taslimi, Betul Sen, Selma Bal, Aydin Aktas, Muhittin Aygun, Morteza Sadeghi, Ilhami Gulcin
Summary: This work focuses on the synthesis, characterization, crystal structure, and biological activity of a new series of PEPPSI type Pd(II)NHC complexes. The complexes were characterized using NMR, FTIR, and elemental analysis, and the crystal structure of complex 1c was determined through X-ray diffraction. The complexes showed potent inhibitory effects on acetyl-cholinesterase, butyrylcholinesterase, and carbonic anhydrases. Molecular docking studies identified specific complexes that exhibited significant inhibition against the target enzymes.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Muserref Hilal Sehitoglu, Rahime Ozlem Oztopuz, Namik Kilinc, Mehmet Akif Ovali, Basak Buyuk, Ilhami Gulcin
Summary: In this study, the effects of thymol treatments on sepsis response were investigated. A sepsis model was created with cecal ligation and perforation (CLP) in rats. Thymol treatment resulted in a significant decrease in pro-inflammatory cytokines and ET-1 gene expression, while the sepsis group showed an increase. The findings suggest that thymol therapy may reduce sepsis-related morbidity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Aliverdi Karimov, Parham Taslimi, Arzu Orujova, Khuraman Mammadova, Dursun Kisa, Vagif Farzaliyev, Afsun Sujayev, Nastaran Sadeghian, Tugba Taskin-Tok, Saleh Alwasel, Ilhami Gulcin
Summary: In this study, a series of S-(Acyloxy)butyl-N,N-Diethyldithiocarbamate compounds (P1-P7) were synthesized and characterized. The compounds were tested for their effects on metabolic enzymes and compared to reference compounds. Molecular docking simulations showed their binding interactions with AChE, BChE, and alpha-glucosidase. Compound P6 exhibited strong distant bond interactions with tacrine for AChE and BChE, while compound P4 showed good interactions with alpha-glucosidase.
Article
Chemistry, Multidisciplinary
Ufuk Atmaca, Ruya Saglamtas, Yusuf Sert, Murat Celik, Ilhami Gulcin
Summary: This article reports a highly effective one-pot synthesis of novel isoindolinones through intramolecular cyclization of various 2-benzoylbenzoic acid derivatives in mild conditions in the absence of a metal catalyst, using chlorosulfonyl isocyanate as the catalyst. The newly synthesized compounds were tested against metabolic enzymes associated with Alzheimer's disease, type-2 diabetes mellitus, epilepsy, and glaucoma. The novel isoindolinones showed potent inhibition ability against AChE, BChE, alpha-glycosidase, hCA I, and hCA II enzymes.
Article
Biochemistry & Molecular Biology
Hakan Inci, Ebubekir Izol, Mustafa Abdullah Yilmaz, Mehmet Ilkaya, Zeynebe Bingol, Ilhami Gulcin
Summary: This study evaluated the antioxidant and enzyme inhibition effects of Apilarnil. The antioxidant activity of Apilarnil was lower than standard molecules, but it exhibited higher radical scavenging ability in the DPPH assay. Furthermore, its enzyme inhibition effects were tested against various enzymes. The phytochemical composition of Apilarnil was also determined, with quinic acid, fumaric acid, aconitic acid, kaempferol, and quercetin being the most abundant compounds. Overall, Apilarnil showed effective antioxidant properties compared to standard antioxidants.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Cetin Bayrak, Parham Taslimi, Namik Kilinc, Ilhami Gulcin, Abdullah Menzek
Summary: In this study, the natural bromophenol butyl 2-(3,5-dibromo-4-hydroxyphenyl)acetate (1) and indene derivatives 34 and 35 were successfully synthesized. Several known natural bromophenols and their derivatives were also synthesized. The synthesized compounds exhibited strong inhibition effects against acetylcholinesterase, butyrylcholinesterase, and α-glycosidase enzymes.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Feyzi Sinan Tokali, Parham Taslimi, Burak Tuzun, Ahmet Karakus, Nastaran Sadeghian, Ilhami Gulcin
Summary: In this study, novel quinazolinone compounds were successfully synthesized and their inhibition properties on multiple metabolic enzymes were investigated. Molecular docking study was performed to analyze the interactions of the most potent compounds with enzymes. Additionally, the ADME/T properties of the compounds were investigated.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Pharmacology & Pharmacy
Lokman Durmaz, Hatice Kiziltas, Hasan Karagecili, Saleh Alwasel, Lhami Gulcin
Summary: The study found that spiraeoside in onions has antioxidant and enzyme inhibition abilities, which may have potential as a medicine for diseases such as Alzheimer's disease, diabetes, and glaucoma.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hasan Karagecili, Ebubekir Izol, Ekrem Kirecci, Ilhami Gulcin
Summary: The antioxidant and enzyme inhibition activities of Tayfi grape extracts were studied and found to be effective, especially against Staphylococcus aureus and Escherichia coli bacteria. Clinical pharmacology studies can support the use of Tayfi grape extracts for treating certain diseases.