TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A

(2017) Jinzhong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics

(2017) Lihua Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages

(2016) Nunzia Pastore et al.   Autophagy

ER–endosome contact sites in endosome positioning and protrusion outgrowth

(2016) Camilla Raiborg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

TFEB and TFE3 are novel components of the integrated stress response

(2016) J. A. Martina et al.   EMBO JOURNAL

Folliculin directs the formation of a Rab34–RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes

(2016) Georgina P Starling et al.   EMBO REPORTS

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

(2016) Shogo Wada et al.   GENES & DEVELOPMENT

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo

(2016) Samantha S. Dykes et al.   Oncotarget

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase

(2015) Alex Pinder et al.   CELLULAR SIGNALLING

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion

(2015) Valentina Marchesin et al.   JOURNAL OF CELL BIOLOGY

Failure of lysosome clustering and positioning in the juxtanuclear region in cells deficient in rapsyn

(2015) M. Aittaleb et al.   JOURNAL OF CELL SCIENCE

Transmembrane Protein 55B Is a Novel Regulator of Cellular Cholesterol Metabolism

(2014) Marisa W. Medina et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

(2014) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer

(2014) I. R. Macpherson et al.   JOURNAL OF CELL SCIENCE

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases

(2014) Lionel Trésaugues et al.   STRUCTURE

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

(2013) K. Krzewski et al.   BLOOD

JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes

(2013) Catherine M. Drerup et al.   PLoS Genetics

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Melanoregulin is stably targeted to the melanosome membrane by palmitoylation

(2012) Xufeng S. Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Rab7 and Arl8 GTPases are Necessary for Lysosome Tubulation in Macrophages

(2012) Amra Mrakovic et al.   TRAFFIC

Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma SCC-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways

(2011) Siu-Wan Ip et al.   CELL BIOCHEMISTRY AND FUNCTION

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility

(2011) Faneng Sun et al.   EMBO JOURNAL

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

(2011) Fumiko Matsuzaki et al.   MOLECULAR BIOLOGY OF THE CELL

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

ARF6 Interacts with JIP4 to Control a Motor Switch Mechanism Regulating Endosome Traffic in Cytokinesis

(2009) Guillaume Montagnac et al.   CURRENT BIOLOGY

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4

(2009) Tatiana Isabet et al.   EMBO JOURNAL

Identification of the Penta-EF-hand Protein ALG-2 as a Ca2+-dependent Interactor of Mucolipin-1

(2009) Silvia Vergarajauregui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol Synthesis Inhibitor U18666A and the Role of Sterol Metabolism and Trafficking in Numerous Pathophysiological Processes

(2009) Richard J. Cenedella   LIPIDS

Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34

(2009) Li Chen et al.   MOLECULAR MEMBRANE BIOLOGY

Proteomics of the lysosome

(2008) Torben Lübke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

(2008) Shunsuke Kimura et al.   CELL STRUCTURE AND FUNCTION

Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells

(2008) Faisal Thayyullathil et al.   FREE RADICAL BIOLOGY AND MEDICINE