Article
Cell Biology
Fereshteh Moradi, Marco Fiocchetti, Maria Marino, Christopher Moffatt, Jeffrey A. Stuart
Summary: Studies have shown that the effects of E-2 and SERMs on cell physiology are strongly influenced by culture conditions, affecting mitochondrial abundance, network characteristics, and H2O2 production.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Oncology
Tongke Chen, Junbo Chen, Tianni Zeng, Qianying Huang, Di Chen, Hong Chen, Jiayao Chen, Bin Zheng, Mengting Wang, Shinuo Chen, Jichen Dai, Hanxiao Sun, Tongzuan Chen, Yuwen Huang, Liqian Zhao, Shumei Ma, Xiaodong Liu
Summary: This study aimed to elucidate the crosstalk between redox reaction and metabolic remodeling in inhibiting gastric cancer cell metastasis. It demonstrated that WZ35, a curcumin analog, exhibited potent anti-proliferative and anti-metastasis properties. The study further identified the mechanism by which WZ35 maintained glutathione depletion in gastric cancer cells.
Article
Biochemistry & Molecular Biology
Ali Emami, Esmaeil Babaei, Alaadin Nagishbandi, Hewa Jalal Azeez, Mohammad Ali Hosseinpour Feizi, Ashraf Golizadeh
Summary: Gemini-Cur significantly increases cellular uptake in AGS cells compared to Cur, leading to reduced cell viability in a time- and dose-dependent manner. It also induces G2/M cell cycle arrest followed by apoptosis in a time-dependent manner, suggesting its potential as an anticancer agent.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Multidisciplinary Sciences
Elisa B. Randi, Karim Zuhra, Laszlo Pecze, Theodora Panagaki, Csaba Szabo
Summary: In mammalian cells, cyanide exhibits a biphasic effect on mitochondrial Complex IV activity, stimulating it at low concentrations and inhibiting it at higher concentrations. Low levels of cyanide lead to increased cell proliferation and ATP production, while higher levels result in inhibition of cellular bioenergetics. The presence of cyanide-producing enzymes in mammalian cells suggests a regulatory role for endogenous cyanide.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Renjun Gu, Yawen Xia, Pengfei Li, Defang Zou, Keqin Lu, Lang Ren, Hongru Zhang, Zhiguang Sun
Summary: Gastric cancer is a common type of cancer with surgery as the main treatment method. However, it is expensive and painful, and patients often experience recurrence. Ferroptosis, a form of cell death dependent on iron, provides a new perspective in cancer therapy. This review summarizes the latest findings on ferroptosis regulation in gastric cancer, discusses the potential of drugs and genes in inducing ferroptosis for treatment and drug resistance, explores the relationship between ferroptosis and the tumor microenvironment in gastric cancer, and suggests areas for future research to accelerate the clinical utility of ferroptosis induction as a treatment strategy for gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ming-Fang Wu, Yen-Hsiang Huang, Ling-Yen Chiu, Shur-Hueih Cherng, Gwo-Tarng Sheu, Tsung-Ying Yang
Summary: Curcumin induces apoptosis in chemoresistant lung cancer cells through generation of ROS, and p38 MAPK is identified as a crucial signaling pathway for this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hailong Shi, Yuanyuan Cheng, Qimei Shi, Wenzhi Liu, Xue Yang, Shuang Wang, Lin Wei, Xiangming Chen, Hao Fang
Summary: Myoferlin is a newly identified oncogene that is associated with tumor metastasis, intracellular ROS production, and energy metabolism. Its function in regulating gastric cancer cell migration and ROS accumulation has not been determined.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Peticha Tanprasert, Sirikan Limpakan (Yamada), Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Summary: This review discusses the homeostasis of gastric cancer cells and highlights the potential role of mitochondria in gastric cancer therapy.
Article
Pharmacology & Pharmacy
Xiaohui Liang, Ping Wang, Chun Yang, Fei Huang, Hui Wu, Hailian Shi, Xiaojun Wu
Summary: Galangin inhibits the growth of MGC 803 cells by inducing apoptosis and decreasing cell proliferation, possibly mediated by modulating the STAT3/ROS axis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Handong Xu, Can Hu, Yi Wang, Yunfu Shi, Li Yuan, Jingli Xu, Yanqiang Zhang, Jiahui Chen, Qin Wei, Jiangjiang Qin, Zhiyuan Xu, Xiangdong Cheng
Summary: Gastric cancer (GC) is a deadly malignancy that requires new therapeutic targets for effective treatment. Glutathione peroxidase-2 (GPx2) was found to be overexpressed in clinical GC samples and negatively correlated with prognosis. Knockdown of GPx2 inhibited GC progression and metastasis by suppressing the KYNU-kyn-AhR signaling pathway, which was activated by reactive oxygen species (ROS) accumulation.
Article
Environmental Sciences
Li Ma, Huachang Zhang, Chuntong Liu, Mengke Liu, Fugen Shangguan, Yan Liu, Shude Yang, Hua Li, Jing An, Shuling Song, Qizhi Cao, Guiwu Qu
Summary: CBD inhibits the growth of ovarian cancer cells by disrupting LAIR-1-mediated interference with mitochondrial bioenergy metabolism and the PI3K/AKT/mTOR pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sylwia Ciesielska, Izabella Slezak-Prochazka, Patryk Bil, Joanna Rzeszowska-Wolny
Summary: In living cells, there are specific systems to maintain redox homeostasis, involving enzymes that produce ROS and enzymes that neutralize ROS. Many of these enzymes are targeted by miRNAs, which play important roles in regulating cellular redox balance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Deepika Ramu, Teoh Wei Shan, Jayshree L. Hirpara, Shazib Pervaiz
Summary: The process of carcinogenesis involves a complex interplay between various cellular pathways, including alterations in redox metabolism and disruption of cell cycle checkpoints. Oxidative stress and cellular senescence play crucial roles in cancer development, serving as potential therapeutic targets for novel anticancer strategies.
Article
Biochemistry & Molecular Biology
Mohammed Ahmed Ismail Alhasawi, Mohammad Aatif, Ghazala Muteeb, Mir Waqas Alam, Mohamed El Oirdi, Mohd Farhan
Summary: Curcuminoids inhibit cancer cell proliferation and induce cell death by reacting with intracellular copper to generate ROS and cause DNA damage. Copper supplementation increases the sensitivity of normal cells to curcumin-mediated growth inhibition.
Article
Biochemistry & Molecular Biology
Lihua Wang, Lijie Han, Zheying Tao, Zheng Zhu, Lei Han, Zhenfei Yang, Hao Wang, Dandan Dai, Liang Wu, Zhengzhong Yuan, Tongke Chen
Article
Multidisciplinary Sciences
Lihua Wang, Feng Dong, Peter S. Reinach, Dandan He, Xiaoting Zhao, Xiaoyan Chen, Dan-Ning Hu, Dongsheng Yan
Article
Biochemistry & Molecular Biology
Lihua Wang, Zheng Zhu, Lei Han, Liqian Zhao, Jialei Weng, Hongbao Yang, Shijia Wu, Kaiyuan Chen, Liang Wu, Tongke Chen