Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2

Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid

(2016) Daniel H. Hwang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Initial hyperinsulinemia and subsequent β-cell dysfunction is associated with elevated palmitate levels

(2016) Johan Staaf et al.   PEDIATRIC RESEARCH

Obesity Statistics

(2016) Kristy Breuhl Smith et al.   PRIMARY CARE

MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis

(2015) Yi Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-κB both in vitro and in vivo

(2015) Chunlai Zeng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway

(2015) Ying Ying et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells

(2015) Huiqun Tian et al.   Nutrients

Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

(2014) Michele Cavalera et al.   Translational Research

Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin

(2013) Hyun-Ju Jang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Free fatty acid determination in plasma by GC-MS after conversion to Weinreb amides

(2013) Sarojini J. K. A. Ubhayasekera et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cardiac Dysfunction and Oxidative Stress in the Metabolic Syndrome: an Update on Antioxidant Therapies

(2013) Olesya Ilkun et al.   CURRENT PHARMACEUTICAL DESIGN

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Short-Term Hyperinsulinemia and Hyperglycemia Increase Myocardial Lipid Content in Normal Subjects

(2012) Yvonne Winhofer et al.   DIABETES

Toll-like Receptor Signaling Pathways in Cardiovascular Diseases: Challenges and Opportunities

(2012) Faezeh Moghimpour Bijani et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat kidney and heart

(2012) Yong Pan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

An overview of the Amber biomolecular simulation package

(2012) Romelia Salomon-Ferrer et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Evaluation and Discovery of Novel Synthetic Chalcone Derivatives as Anti-Inflammatory Agents

(2011) Jianzhang Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

(2010) Mohan R. Dasu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells

(2010) David Álvarez-Guardia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Loss of PI3Kγ Enhances cAMP-Dependent MMP Remodeling of the Myocardial N-Cadherin Adhesion Complexes and Extracellular Matrix in Response to Early Biomechanical Stress

(2010) Danny Guo et al.   CIRCULATION RESEARCH

Inflammation, a Link between Obesity and Cardiovascular Disease

(2010) Zhaoxia Wang et al.   MEDIATORS OF INFLAMMATION

Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies

(2009) Marianne U Jakobsen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Activation of NF-κB by Palmitate in Endothelial Cells

(2009) Ezekiel Maloney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Evaluating the Performance of the ff99SB Force Field Based on NMR Scalar Coupling Data

(2009) Lauren Wickstrom et al.   BIOPHYSICAL JOURNAL

Plasma Fatty Acid Composition as a Predictor of Arterial Stiffness and Mortality

(2009) Simon G. Anderson et al.   HYPERTENSION

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Free fatty acids as a cardiovascular risk factor

(2008) Stefan Pilz et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts

(2008) M MARINO et al.   JOURNAL OF NEUROIMMUNOLOGY

Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications

(2008) Arion Kennedy et al.   JOURNAL OF NUTRITION

Cardiac Remodeling in Obesity

(2008) E. Dale Abel et al.   PHYSIOLOGICAL REVIEWS