Article
Biochemistry & Molecular Biology
Sergio Davinelli, Alessandro Medoro, Mariano Intrieri, Luciano Saso, Giovanni Scapagnini, Jing X. Kang
Summary: The transcription factor NRF2 and its endogenous inhibitor KEAP1 are important for maintaining cellular redox homeostasis. Activation of NRF2 can provide cellular protection against age-related diseases. Recent studies have identified compounds, including omega-3 polyunsaturated fatty acids (PUFAs) and their electrophilic derivatives, that may restore NRF2 function in aging cells. These findings suggest that n-3 PUFAs could be potential agents for preventing chronic diseases and restoring age-related NRF2 impairment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dagmar Heydeck, Christoph Ufer, Kumar R. Kakularam, Michael Rothe, Thomas Liehr, Philippe Poulain, Hartmut Kuhn
Summary: The researchers created transgenic mice expressing human ALOX15 under the control of the aP2 promoter, which showed high expression in adipocytes, bone marrow cells, and peritoneal macrophages. The catalytic activity of the transgenic enzyme was confirmed through activity assays and plasma metabolite analysis. The aP2-ALOX15 mice exhibited gender-specific differences in body-weight kinetics compared to the wildtype controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sahdeo Prasad, Dan DuBourdieu, Ajay Srivastava, Prafulla Kumar, Rajiv Lall
Summary: Curcumin, an active compound in turmeric, has various pharmacological properties, but its effectiveness is limited by its nature. Metal-curcumin complexes have been developed to enhance solubility and absorption, showing positive effects against chronic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Hajar Heidari, Mehrnaz Shojaei, Gholamreza Askari, Muhammed Majeed, Mohammad Bagherniya, George E. Barreto, Amirhossein Sahebkar
Summary: Migraine is a neurovascular condition that affects about 15% of the global population. The exact pathophysiology and etiology of migraine are still unclear, but oxidative stress, inflammation, and neuroendocrine imbalances are identified as critical risk factors. Curcumin, extracted from turmeric, shows promise in preventing and controlling migraine due to its anti-inflammatory, antioxidative, antiprotein aggregate, and analgesic effects. More studies are needed to fully understand the efficacy of curcumin on clinical symptoms of migraine and its potential mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Nutrition & Dietetics
Ivana Djuricic, Philip C. Calder
Summary: Oxidative stress and inflammation are important contributors to chronic non-communicable diseases. Different types of fatty acids have varying effects on chronic diseases, with moderate intake of Ω-6 fatty acids lowering the risk of cardiovascular diseases and Ω-3 fatty acids helping to reduce inflammation levels.
Review
Food Science & Technology
Marilyn S. Campbell, Nicholas A. Carlini, Bradley S. Fleenor
Summary: Intense exercise can cause muscle damage and decreased physical performance, while curcumin may help alleviate these symptoms. Research suggests that curcumin can improve self-perceived pain and muscle damage, increase antioxidant capacity, and reduce oxidative stress.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Pinyi Liu, Yanbing Wang, Ge Yang, Qihe Zhang, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Short-chain fatty acids (SCFAs), produced during bacterial fermentation of dietary fiber, play crucial roles in regulating inflammation, carcinogenesis, intestinal barrier function, and oxidative stress. Their signaling mechanisms involve histone acetylation promotion and activation of G-protein-coupled receptors. SCFAs have a wide range of positive effects and show high therapeutic potential in human-related diseases.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Zhang Wei, Kang Pinfang, Zhou Jing, Yao Zhuoya, Qian Shaohuan, Shi Chao
Summary: This study investigates the effects of curcumin on diabetic cardiomyopathy by regulating the AKT pathway and promoting the transfer of Nrf2 into the nucleus. Curcumin was found to inhibit cell pyroptosis by reducing reactive oxygen species accumulation and mitochondrial damage in diabetic myocardium. The protective effects of curcumin were diminished when the Nrf2 pathway was blocked. These findings suggest that curcumin has potential therapeutic effects in treating diabetic cardiomyopathy.
MEDIATORS OF INFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Minglei Bi, Danyi Li, Jin Zhang
Summary: Ischemia-reperfusion injury (IRI) is a common pathological process after organ transplantations, and the damage caused by IRI is often ignored. Curcumin, a polyphenol compound, has been shown to have protective effects against IRI through its anti-oxidative stress, anti-inflammation and anti-apoptosis properties. However, there are still controversies about the underlying mechanisms of curcumin's effects on IRI. This review aims to summarize the protective role of curcumin against IRI and clarify its underlying mechanisms, providing a novel idea for the therapy of IRI.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Javier Avila-Roman, Patricia Gomez-Villegas, Carla C. C. R. de Carvalho, Javier Vigara, Virginia Motilva, Rosa Leon, Elena Talero
Summary: The production of reactive oxygen species (ROS) is important in the progression of inflammatory diseases. Antioxidants that can scavenge free radicals and reduce oxidative damage are crucial for prevention and treatment of these diseases. Haloarchaea, extremely halophilic microorganisms that live in high-salt environments, have unique compounds with bioactive properties that have not been fully explored. This study aims to assess the potential of haloarchaea as a new source of natural antioxidant and anti-inflammatory agents.
Article
Food Science & Technology
Eliana Jardim Fernandes, Elize Aparecida Santos Musachio, Luana Barreto Meichtry, Dieniffer Espinosa Janner, Franciele Romero Machado Balok, Magna Sotelo Barrientos, Nathalie Savedra Gomes, Ketnne Hanna Poleto Pinto, Mustafa Munir Mustafa Dahleh, Andrieli Rodrigues, Sandra Elisa Haas, Silvana Peterini Boeira, Marina Prigol, Gustavo Petri Guerra
Summary: We investigated the potential toxic effects of chronic exposure to free curcumin and curcumin-loaded nanocapsules in Drosophila melanogaster, demonstrating the safe applications of nanoencapsulated curcumin.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Meng Sun, Rong Wang, Rui Xia, Zhengyuan Xia, Zhilin Wu, Tingting Wang
Summary: Mechanisms contributing to myocardial ischemia-reperfusion (I/R) injury are complex, but Dexmedetomidine (DEX) shows potential in ameliorating this injury in diabetic states. DEX activates the PI3K/Akt and associated GSK-3 beta pathway, alleviates endoplasmic reticulum stress, and inhibits apoptosis. Additionally, DEX up-regulates autophagy, reduces ROS production, and inhibits inflammation via HMGB1 pathways, leading to the protection against diabetic myocardial I/R injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sejin Kim, Hyunjae Lee, Hanbyeol Moon, Ran Kim, Minsuk Kim, Seongtae Jeong, Hojin Kim, Sang Hyeon Kim, Soo Seok Hwang, Min Young Lee, Jongmin Kim, Byeong-Wook Song, Woochul Chang
Summary: Cardiac tissue damage following ischemia leads to cardiomyocyte apoptosis and myocardial fibrosis. The active polyphenol flavonoid or catechin epigallocatechin-3-gallate (EGCG) protects ischemic myocardium and is involved in the regulation of endothelial-to-mesenchymal transition (EndMT). In this study, EGCG treatment was shown to regenerate ischemic tissue and induce cardioprotection by regulating proteins associated with the EndMT process, as well as positively regulating cardiomyocyte apoptosis and fibrosis.
Review
Immunology
Ping Hu, Kaiqi Li, Xiao-Xu Peng, Yufei Kan, Tong-Jia Yao, Zi-Yu Wang, Zhaojian Li, Hao-Yu Liu, Demin Cai
Summary: Medicinal homologous foods in China have been known for their dual roles as both food and medicine for thousands of years, benefiting human and animal health. Curcumin, derived from medicinal homologous foods like curcuma longa rhizome, has significant pharmacological functions in various diseases, including anti-oxidative stress, anti-inflammation, and anti/pro-apoptosis. However, the potential mechanisms of curcumin-derived modulation still require further research and global attention. This mini-review summarizes the latest achievements in curcumin's immune-regulation signals and provides targetable strategies, which will contribute to the future human clinical applications of curcumin and other extracts from medicinal homologous foods.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laurent Dube, Schohraya Spahis, Karelle Lachaine, Andreanne Lemieux, Hanine Monhem, Sarah-Maude Poulin, Carolane Randoll, Eva Travaillaud, Nour-El-Houda Ould-Chikh, Valerie Marcil, Edgard Delvin, Emile Levy
Summary: Metabolic syndrome is a serious global public health issue with significant health risks, requiring alternative therapeutic options. Recent studies have shown increased interest in specialized pro-resolving lipid mediators in regulating metabolic derangements.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Dentistry, Oral Surgery & Medicine
Amr Alsabbagh, Terry L. Robins, Ariel Harriman, Linda Jackson-Boeters, Mark R. Darling, Zia A. Khan, Christina McCord
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yali Zhang, Hongjin Chen, Wenxin Zhang, Yan Cai, Peiren Shan, Di Wu, Bing Zhang, Hui Liu, Zia A. Khan, Guang Liang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Cardiac & Cardiovascular Systems
Shiju Ye, Wu Luo, Zia A. Khan, Gaojun Wu, Lina Xuan, Peiren Shan, Ke Lin, Taiwei Chen, Jingying Wang, Xiang Hu, Shengjie Wang, Weijian Huang, Guang Liang
CIRCULATION RESEARCH
(2020)
Article
Multidisciplinary Sciences
Yi Wang, Wu Luo, Jibo Han, Zia A. Khan, Qilu Fang, Yiyi Jin, Xuemei Chen, Yali Zhang, Meihong Wang, Jianchang Qian, Weijian Huang, Hazel Lum, Gaojun Wu, Guang Liang
NATURE COMMUNICATIONS
(2020)
Review
Gastroenterology & Hepatology
Lina Chen, Abdulaziz Almudaires, May Alzahrani, Karim Qumosani, Subrata Chakrabarti
Summary: IgG4-related disease involving the digestive tract is rare, and causing gastric outlet obstruction is even rarer. In this reported case, Whipple's procedure diagnosed IgG4-related disease, and symptoms were resolved with mycophenolate mofetil and prednisone without recurrence.
BMC GASTROENTEROLOGY
(2021)
Article
Peripheral Vascular Disease
Zheng Xu, Wu Luo, Lingfeng Chen, Zaishou Zhuang, Daona Yang, Jianchang Qian, Zia A. Khan, Xinfu Guan, Yi Wang, Xiaokun Li, Guang Liang
Summary: This study reveals that Ang II alters FGFR1 signaling to mediate renal dysfunction. Increased FGFR1 activity was found in renal epithelial cells from subjects with hypertension and Ang II challenged mice. Mechanistically, Ang II-activated FGFR1 leads to STAT3 activation, which is responsible for renal fibrosis.
Article
Immunology
Ke Lin, Wu Luo, Na Yang, Lan Su, Hao Zhou, Xiang Hu, Yi Wang, Zia A. Khan, Weijian Huang, Gaojun Wu, Guang Liang
Summary: The study reveals that Ang II induces inflammation and fibrosis in renal tubular epithelial cells through MyD88. Inhibition of MyD88 decreases these adverse effects and protects renal function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wu Luo, Ke Lin, Junyi Hua, Jibo Han, Qiuyan Zhang, Lingfeng Chen, Zia A. Khan, Gaojun Wu, Yi Wang, Guang Liang
Summary: Diabetes-induced chronic inflammation contributes to the development of diabetic cardiomyopathy (DCM). This study investigates the pharmacological effects and mechanisms of Schisandrin B (Sch B), a natural anti-inflammatory compound, against DCM. Results show that Sch B protects against high glucose-induced hypertrophy and fibrosis in cultured cardiomyocytes via MyD88-dependent inflammatory gene expression. Sch B inhibits MyD88 activation and does not affect MyD88-independent Toll-like receptor signaling. In mouse models, Sch B treatment improves heart function, reduces myocardial injuries, and decreases inflammatory cytokine secretion. Cardiomyocyte-specific MyD88 knockout also protects against cardiac inflammation and injury in diabetic mice. Overall, this study highlights the importance of MyD88 in DCM and the potential of Sch B as a therapeutic target for reducing inflammation in DCM.
Article
Pharmacology & Pharmacy
Rong Chen, Shiqing Zhang, Fang Liu, Lin Xia, Chong Wang, Siamak Sandoghchian Shotorbani, Huaxi Xu, Subrata Chakrabarti, Tianqing Peng, Zhaoliang Su
Summary: Cardiac-resident macrophages (CRMs) have important roles in cardiac homeostasis, function, and regeneration. This study investigated the changes of CRMs during cardiac ontogeny and their contribution to cardiac regeneration. The findings reveal the dynamic subsets of CRMs during development and their ability to regulate cardiomyocyte proliferation, highlighting their potential in cardiac repair and regeneration.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biology
Jina J. Y. Kum, Christopher J. Howlett, Zia A. Khan
Summary: Short-term diabetes enhances adipogenesis in the bone marrow and suppresses TGFB signaling. These findings may inform the development of novel therapeutic targets to restore regenerative stem cell function in diabetic patients.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wu Luo, Yiyi Jin, Yuchen Jiang, Libin Yang, Haowen Xu, Di Wu, Yanmei Zhang, Lina Yin, Zia Ali Khan, Guang Liang, Yi Wang
Summary: Through experiments, it was found that DCLK1 binds to and phosphorylates IKK beta, activating the NF-kappa B pathway and regulating inflammatory responses. Deficiency in DCLK1 prevents NF-kappa B activation and cytokine production, protecting against inflammatory diseases.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Multidisciplinary Sciences
Parisa Sooshtari, Biao Feng, Saumik Biswas, Michael Levy, Hanxin Lin, Zhaoliang Su, Subrata Chakrabarti
Summary: This study found that ANRIL gene alteration may play an important role in diabetic nephropathy by regulating the expression of multiple pathogenetic molecules, affecting various metabolic pathways, apoptosis, and synthesis and degradation of extracellular matrix proteins. ANRIL may be a potential drug target for DN and other chronic diabetic complications.
Article
Dentistry, Oral Surgery & Medicine
Benjamin Rogala, Zia Ali Khan, Linda Jackson-Boeters, Mark Roger Darling
Summary: This study investigated the immunoreactivity and expression profiles of granular cell tumours (GCTs), and found evidence supporting an antigen-presenting cell (APC) phenotype and identified a new neural crest cell (NCC) marker, GAP43, in GCTs. However, RT-qPCR failed to determine the NCC developmental phenotype of GCTs, likely due to technical issues.
Article
Pathology
Jacqueline Cox, Zia Khan, Linda Jackson-Boeters, Jerrold Armstrong, Mark Darling
Summary: The study found a significant increase in mRNA expression levels of KLK1, KLK4, KLK10, KLK12, and KLK15 in polymorphous adenocarcinoma tissue samples, with immunohistochemistry results indicating the presence of KLKs in tumor cells. This suggests a potential role of kallikreins in tumor development and progression.
HEAD & NECK PATHOLOGY
(2021)
Article
Pathology
Zachary Kerr, Alyssa Hayter, Zia Khan, Mark Darling
HEAD & NECK PATHOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)