Review
Immunology
Andrea Farini, Chiara Villa, Luana Tripodi, Mariella Legato, Yvan Torrente
Summary: Muscular dystrophies and inflammatory myopathies are muscular disorders characterized by progressive muscle weakness and mass loss, with shared features of inflammation and immune response. Immune mechanisms involved include complement cascade activation and auto-antibodies directed against muscular proteins.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pei-Chi Chan, Po-Shiuan Hsieh
Summary: Obesity is characterized by excessive accumulation of adipose tissue with alterations in immune and metabolic responses. The role of chemokines and chemokine receptors in obesity-related inflammation and metabolism dysregulation is complex and not fully understood. Understanding these mechanisms could lead to potential therapeutic targets for controlling immune and metabolic disorders associated with obesity in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Luiz Henrique Agra Cavalcante-Silva, Deyse Cristina Madruga Carvalho, Essia de Almeida Lima, Jose G. F. M. Galvao, Juliane S. de Franca da Silva, Jose Marreiro de Sales-Neto, Sandra Rodrigues-Mascarenhas
Summary: COVID-19, triggered by SARS-Cov2 infection, is a multisystem inflammatory disorder characterized by acute respiratory distress syndrome, cytokine-driven hyper inflammation, and leukocytes count changes. Neutrophils have been identified as essential effector cells in the development of COVID-19, utilizing mechanisms such as neutrophil enzymes, cytokines, and neutrophil extracellular traps. This review summarizes significant findings regarding neutrophils and their effector mechanisms in COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
David M. M. Cauvi, Dennis Hawisher, Julia Derunes, Antonio De Maio
Summary: Phospholipids play important roles in cellular membranes, vesicles, and lipid nanoparticles. The presence of phospholipids can alter the transcriptome and proteome of cells, as well as modulate signaling pathways, leading to changes in cellular functions.
Review
Immunology
Priscilla Vilela dos Santos, Debora Nonato Miranda de Toledo, Debora Maria Soares de Souza, Tatiana Prata Menezes, Luiza Oliveira Perucci, Zolder Marinho Silva, Daniela Caldas Teixeira, Ed Wilson Rodrigues Vieira, Valter Ferreira de Andrade-Neto, Nathalia Sernizon Guimaraes, Andre Talvani
Summary: This study evaluated the available information on inflammatory and regulatory plasma mediators in pregnant women diagnosed with toxoplasmosis. Eight studies were included in the analysis, and the results showed that infected pregnant women had higher levels of IL-5, IL-6, IL-8, IL-17, CCL5, and IL-10 in their plasma. These findings suggest that the immune status of pregnant women determines the course of T. gondii infection, and the balance between inflammatory and regulatory cytokines mitigates the adverse effects on the placenta and fetus.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Ophthalmology
Md Huzzatul Mursalin, Phillip S. Coburn, Frederick C. Miller, Erin T. Livingston, Roger Astley, Michelle C. Callegan
Summary: The absence of CXCL2 or CXCL10 in Bacillus endophthalmitis resulted in retained retinal function and reduced inflammation. The absence of CXCL2 had a better clinical outcome than the absence of CXCL10. Using anti-CXCL2 and anti-CXCL10 limited inflammation during B. cereus endophthalmitis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sarah Thompson, Chong Yun Pang, Krishna Mohan Sepuru, Seppe Cambier, Thomas P. Hellyer, Jonathan Scott, A. John Simpson, Paul Proost, John A. Kirby, Krishna Rajarathnam, Neil S. Sheerin, Simi Ali
Summary: Chemokine CXCL8 plays a crucial role in human immune response by mediating neutrophil migration and activation at sites of infection and injury. This study demonstrates that peroxynitrite can nitrate CXCL8, leading to impaired neutrophil migration and activation. The nitrated chemokine showed reduced ability to induce neutrophil migration in vitro and failed to promote leukocyte recruitment in vivo due to impaired receptor signaling and binding to glycosaminoglycans. The presence of nitrated CXCL8 was detected in bronchoalveolar lavage samples from patients with pneumonia, providing the first direct evidence of chemokine nitration in human pathophysiology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Georgios K. Vasileiadis, Anna-Carin Lundell, Yuan Zhang, Kerstin Andersson, Inger Gjertsson, Anna Rudin, Cristina Maglio
Summary: The study found a positive association between total adiponectin and pro-inflammatory chemokines, as well as markers of inflammation in patients with untreated newly diagnosed RA. However, high-molecular weight adiponectin was only associated with specific chemokines. Leptin and resistin showed no association with plasma chemokines, markers of inflammation, or disease activity scores.
Article
Engineering, Chemical
Marta Smycz-Kubanska, Zdzislawa Kondera-Anasz, Justyna Sikora, Dominika Wendlocha, Patrycja Krolewska-Daszczynska, Aleksandra Englisz, Aleksandra Janusz, Joanna Janusz, Aleksandra Mielczarek-Palacz
Summary: Endometriosis is characterized by the presence of endometrial tissue outside the uterus, and associated with immune dysregulation. The study aimed to investigate the role of chemokines in endometriosis development, finding that certain chemokines in peritoneal fluid may play a key role in disease pathogenesis, with concentrations correlating with disease severity.
Article
Biochemistry & Molecular Biology
Daiane Boff, Remo Castro Russo, Helena Crijns, Vivian Louise Soares de Oliveira, Matheus Silverio Mattos, Pedro Elias Marques, Gustavo Batista Menezes, Angelica Thomaz Vieira, Mauro Martins Teixeira, Paul Proost, Flavio Almeida Amaral
Summary: This study tested the anti-inflammatory effect of CXCL9(74-103) in Klebsiella pneumoniae-induced pneumonia. The treatment with CXCL9(74-103) reduced neutrophil migration, decreased the production of IL-1 beta, and improved lung function in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Vilim Molnar, Vid Matisic, Ivan Kodvanj, Roko Bjelica, Zeljko Jelec, Damir Hudetz, Eduard Rod, Fabijan Cukelj, Trpimir Vrdoljak, Dinko Vidovic, Mario Staresinic, Srecko Sabalic, Borut Dobricic, Tadija Petrovic, Darko Anticevic, Igor Boric, Rok Kosir, Ursula Prosenc Zmrzljak, Dragan Primorac
Summary: Osteoarthritis is a common cause of disability worldwide, affecting all joint tissues equally. The pathogenesis involves low-grade inflammation leading to an imbalance between anabolic and catabolic processes. The complex network of cytokines regulating these processes plays a central role in the development and progression of osteoarthritis, with concentrations of proinflammatory and anti-inflammatory cytokines varying based on disease stage and activity levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Sara Poletti, Mario Gennaio Mazza, Federico Calesella, Benedetta Vai, Cristina Lorenzi, Elena Manfredi, Cristina Colombo, Raffaella Zanardi, Francesco Benedetti
Summary: The study found that elevated levels of chemokines are associated with poor cognitive performance in patients with bipolar disorder, suggesting that an inflammatory state may contribute to neurocognitive deficits.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Immunology
Tong Yue, Yu Shi, Sihui Luo, Jianping Weng, Yali Wu, Xueying Zheng
Summary: Diabetic retinopathy is a common complication of diabetes mellitus that is largely driven by inflammation. Understanding and elucidating the inflammation-related mechanisms is crucial for prevention and management of diabetic retinopathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Psychiatry
Janna McLellan, Danielle H. J. Kim, Matthew Bruce, Alexandra Ramirez-Celis, Judy van de Water
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with multiple etiologies. Maternal immune system dysregulation is a prominent risk factor, and there is emerging evidence for its role as a potential biomarker and pathologically relevant mechanism for ASD development.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Cell Biology
Francisco Diez-Fuertes, Maria Rosa Lopez-Huertas, Javier Garcia-Perez, Esther Calonge, Mercedes Bermejo, Elena Mateos, Pilar Marti, Nuria Muelas, Juan Jesus Vilchez, Mayte Coiras, Jose Alcami, Sara Rodriguez-Mora
Summary: LGMDD2 is a rare form of muscular dystrophy characterized by the addition of a 15-amino acid tail in the C-terminus of the TNPO3 gene. The study found that LGMDD2 patients exhibit a pro-inflammatory state, with alterations in IL-17 signaling pathway and increased activity of metallopeptidases and TNF response. Additionally, LGMDD2 patients have elevated levels of interferons and inflammatory mediators, suggesting an antiviral environment and resistance to HIV-1 infection, but potentially impairing muscular function and worsening disease progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tim Schumertl, Juliane Lokau, Stefan Rose-John, Christoph Garbers
Summary: Interleukin-6 (IL-6) is a pleiotropic cytokine involved in various physiological and pathophysiological functions. It can signal through different pathways, with trans-signaling playing a crucial role in its pro-inflammatory properties. The soluble form of the IL-6 receptor (sIL-6R) is generated by different mechanisms, including proteolysis. Attempts to selectively block IL-6 trans-signaling are being made in pre-clinical animal models and clinical studies for inflammatory bowel disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Dominik M. Schulte, Georg H. Waetzig, Harald Schuett, Marlies Marx, Berenice Schulte, Christoph Garbers, Juliane Lokau, Ann-Kathrin Vlacil, Juliane Schulz, Anna K. Seoudy, Bernhard Schieffer, Philip Rosenstiel, Marcus Seeger, Matthias Laudes, Stefan Rose-John, Ulf Luetzen, Karsten Grote, Stefan Schreiber
Summary: Inflammation plays an important role in atherosclerotic cardiovascular disease, and there is a need for therapies targeting excessive inflammation. A fusion protein called olamkicept has been shown to reduce atherosclerosis independently of LDL cholesterol metabolism in mice, and its use in a patient with high-risk ASCVD also demonstrated a reduction in arterial wall inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Nofar Rosenberg, Matthias Van Haele, Tali Lanton, Neta Brashi, Zohar Bromberg, Hanan Adler, Hilla Giladi, Amnon Peled, Daniel S. Goldenberg, Jonathan H. Axelrod, Alina Simerzin, Chofit Chai, Mor Paldor, Auerlia Markezana, Dayana Yaish, Zohar Shemulian, Dvora Gross, Shanny Barnoy, Maytal Gefen, Osher Amran, Sofie Claerhout, Mirian Fernandez-Vaquero, Maria Garcia-Beccaria, Danijela Heide, Michal Shoshkes-Carmel, Dirk Schmidt Arras, Sharona Elgavish, Yuval Nevo, Hadar Benyamini, Janina E. E. Tirnitz-Parker, Aranzazu Sanchez, Blanca Herrera, Rifaat Safadi, Klaus H. Kaestner, Stefan Rose-John, Tania Roskams, Mathias Heikenwalder, Eithan Galun
Summary: This study reveals that combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA) originates from hepatic progenitor cells (HPCs), not hepatocellular carcinoma (HCC). IL-6 plays a significant role in the aging process of HPCs, suggesting potential therapeutic targets for cHCC-CCA tumors.
JOURNAL OF HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Mohamed I. Saad, Teresa Weng, Joanne Lundy, Linden J. Gearing, Alison C. West, Christopher M. Harpur, Mohammad Alanazi, Christopher Hodges, Daniel Croagh, Beena Kumar, Irit Sagi, Stefan Rose-John, Brendan J. Jenkins
Summary: ADAM17 protease plays a crucial role in the pathogenesis of pancreatitis, with its up-regulation associated with activation of the IL-6 trans-signaling/STAT3 axis. Genetic and therapeutic interventions targeting ADAM17 can ameliorate pancreatitis, reducing inflammatory cell infiltration, necrosis, and fibrosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Saleela M. Ruwanpura, Louise McLeod, Lovisa F. Dousha, Huei J. Seow, Alison C. West, Alice J. West, Teresa Weng, Mohammad Alanazi, Martin MacDonald, Paul T. King, Philip G. Bardin, Cem Gabay, Dennis M. Klinman, Steven Bozinovski, Ross Vlahos, Gary P. Anderson, Stefan Rose-John, Mohamed I. Saad, Brendan J. Jenkins
Summary: Pulmonary emphysema is associated with dysregulated innate immune responses. In this study, the authors investigated the role of innate immune inflammasome complexes in promoting emphysema. They found that ASC, Caspase-1, and AIM2 were up-regulated in emphysematous patients and mouse models of emphysema. AIM2 was associated with elevated levels of IL-1 beta. Blockade of AIM2 and IL-1 receptor ameliorated emphysema in mice. IL-6 trans-signaling was also found to augment AIM2 expression in emphysema.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Miryam Mueller, Claire Saunders, Anke Senftleben, Johannes P. W. Heidbuechel, Birgit Halwachs, Julia Bolik, Nina Hedemann, Christian Roeder, Dirk Bauerschlag, Stefan Rose-John, Dirk Schmidt-Arras
Summary: Tspan8 subfamily members regulate the substrate selectivity of ADAM17 through different strategies, especially by recruiting ADAM17 into Tspan-enriched micro-domains to promote ADAM17-mediated TNF alpha release. This finding reveals the mechanism of Tspan8's involvement in tumorigenesis.
Article
Immunology
Aikaterini Gatsiou, Simon Tual-Chalot, Matteo Napoli, Almudena Ortega-Gomez, Tommy Regen, Rachit Badolia, Valeriana Cesarini, Claudia Garcia-Gonzalez, Raphael Chevre, Giorgia Ciliberti, Carlos Silvestre-Roig, Maurizio Martini, Jedrzej Hoffmann, Rana Hamouche, Joseph R. Visker, Nikolaos Diakos, Astrid Wietelmann, Domenico Alessandro Silvestris, Georgio Georgiopoulos, Ali Moshfegh, Andre Schneider, Wei Chan, Stefan Guenther, Johanne Backs, Shin Kwak, Craig H. Selzman, Kimon Stamatelopoulos, Stefan Rose-John, Christian Trautwein, Ioakim Spyridopoulos, Thomas Braun, Ari Waisman, Angela Gallo, Stavros G. Drakos, Stefanie Dimmeler, Markus Sperandio, Oliver Soehnlein, Konstantinos Stellos
Summary: RNA editor ADAR2 regulates endothelial responses to IL-6, controlling leukocyte trafficking in inflamed and ischemic tissues. ADAR2 is required for IL-6 trans-signaling and immune cell infiltration through suppressing primary microRNA processing.
Article
Neurosciences
Stephan A. Muller, Merav D. Shmueli, Xiao Feng, Johanna Tushaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Summary: In this study, the researchers identified SEZ6 and gp130/IL6ST as physiological substrates of BACE1 in non-human-primate cerebrospinal fluid. They also found a reduction of gp130 in human CSF from a clinical trial with a BACE inhibitor and in plasma of BACE1-deficient mice. These findings provide insights into the relationship between BACE1 and gp130 in neuronal signaling and survival.
MOLECULAR NEURODEGENERATION
(2023)
Article
Immunology
Agatha Schwarz, Rebecca Philippsen, Serena G. Piticchio, Jan N. Hartmann, Robert Haesler, Stefan Rose-John, Thomas Schwarz
Summary: The organ-specific microbiome, particularly the skin microbiome, plays a crucial role in tissue homeostasis by regulating the inflammatory response. Short chain fatty acids (SCFA) induce regulatory T cells (Treg) in the skin and their signal is mediated by the receptor HCA2. Knock-out of HCA2 results in stronger inflammation and a switch of Treg from a suppressive to a proinflammatory type, indicating that the skin microbiome dictates the outcome of the inflammatory reaction.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Stefan Rose-John, Brendan J. Jenkins, Christoph Garbers, Jens M. Moll, Juergen Scheller
Summary: This review discusses the discovery of the IL-6 trans-signalling pathway and the development of biologics that specifically inhibit this pathway. Targeting IL-6 trans-signalling can decrease disease-promoting activities of IL-6 without blocking its protective actions.
NATURE REVIEWS IMMUNOLOGY
(2023)
Meeting Abstract
Ophthalmology
Kristin Hoesel, Buesra Chasan, Christoph Ehlken, Jan Tode, Stefan Rose-John, Johann Roider
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Nofar Rosenberg, Matthias Van Haele, Maria Garcia Beccaria, Mirian Fernandez-Vaquero, Danijela Heide, Neta Barashi, Amnon Peled, Yuval Nevo, Shrona Elgavish, Dirk Schmist-Arras, Hanan Edler, Alina Simerzin, Michal Shoshkes-Carmel, Klaus Kaestner, Hilla Giladi, Stefan Rose-John, Tania Roskams, Mathias Heikenwalder, Eithan Galun
JOURNAL OF HEPATOLOGY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Maytal Gefen, Shanny Layani, Emma Klahr, Mor Hindi, Nofar Rosenberg, Rinat Abramovitch, Nathalie Nachmansson, Adi Yehezkel, Amnon Peled, Jacob Rachmilewitz, Michal Abraham, Michael Berger, Daniel Goldenberg, Nicola Gagliani, Samuel Huber, Irm Hermans-Borgmeyer, Rebecca Haffner-Krausz, Shifra Ben-Dor, Yuval Nevo, Shrona Elgavish, Hadar Benyamini, Mathias Heikenwaelder, Stefan Rose-John, Dirk Schmist-Arras, Achim Krueger, Michael Stuerzl, Elisabeth Naschberger, Frank Tacke, Hilla Giladi, Eithan Galun
JOURNAL OF HEPATOLOGY
(2022)
Article
Respiratory System
Dharmesh Hirani, Cristina M. Alvira, Soula Danopoulos, Carlos Milla, Michele Donato, Lu Tian, Jasmine Mohr, Katharina Dinger, Christina Vohlen, Jaco Selle, Silke Koningsbruggen-Rietschel, Verena Barbarino, Christian Pallasch, Stefan Rose-John, Margarete Odenthal, Gloria S. Pryhuber, Siavash Mansouri, Rajkumar Savai, Werner Seeger, Purvesh Khatri, Denise Al Alam, Joerg Doetsch, Miguel A. Alejandre Alcazar
Summary: This study identified a mechanism in which IL-6 activates macrophages, impairs ATII homeostasis, and disrupts elastic fiber formation, leading to inhibition of lung growth under hyperoxia conditions. Inhibiting IL-6 trans-signaling could promote lung growth.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yo Seph Park, Yukyeong Lee, Na Young Choi, Han Sung Hwang, Stefan Rose-John, Martin Zenke, Kinarm Ko
Summary: Umbilical cord blood is an alternative source of hematopoietic stem cells for transplantation, but the low number of HSCs in cord blood is a limitation. This study found that the combination of HIL-6, SR1, and UM171 had a synergistic effect on expanding UCB-HSCs. Therefore, this combination is the best choice for obtaining HSCs for clinical transplantation.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
