The intrinsic genetic and epigenetic regulator factors as therapeutic targets, and the effect on fetal globin gene expression

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

(2016) L. Breda et al.   BLOOD

A New Krüppel-Like Factor 1 Mutation (c.947G > A or p.C316Y) in Humans Causes β-Thalassemia Minor

(2015) Takenori Nitta et al.   HEMOGLOBIN

Epigenetic regulation of fetal globin gene expression in adult erythroid cells

(2015) Gordon D. Ginder   Translational Research

Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1

(2015) Amanda J. Grieco et al.   PLoS One

DNA polymorphisms at BCL11A, HBS1L-MYB and Xmn1-HBG2 site loci associated with fetal hemoglobin levels in sickle cell anemia patients from Northern Brazil

(2014) Greice Lemos Cardoso et al.   BLOOD CELLS MOLECULES AND DISEASES

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers

(2014) Ralph Stadhouders et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of Xmn1 −158 γG variant with severity and HbF levels in β-thalassemia major and sickle cell anaemia

(2014) Sneha Dadheech et al.   MOLECULAR BIOLOGY REPORTS

The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription

(2014) Won Ju Yun et al.   NUCLEIC ACIDS RESEARCH

Mi2 -mediated silencing of the fetal  -globin gene in adult erythroid cells

(2013) M. Amaya et al.   BLOOD

Clinical experience with fetal hemoglobin induction therapy in patients with  -thalassemia

(2013) K. M. Musallam et al.   BLOOD

Three fingers on the switch

(2013) Michael R. Tallack et al.   CURRENT OPINION IN HEMATOLOGY

Induction of human fetal hemoglobin expression by adenosine-2’,3’-dialdehyde

(2013) Yinghong He et al.   Journal of Translational Medicine

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

(2013) J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reawakening fetal hemoglobin: prospects for new therapies for the  -globin disorders

(2012) D. E. Bauer et al.   BLOOD

LCR 5′ hypersensitive site specificity for globin gene activation within the active chromatin hub

(2012) Kenneth R. Peterson et al.   NUCLEIC ACIDS RESEARCH

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

(2011) A. Wilber et al.   BLOOD

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells

(2011) Inderdeep S. Kalra et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transcription Factors KLF1 and KLF2 Positively Regulate Embryonic and Fetal β-Globin Genes through Direct Promoter Binding

(2011) Yousef N. Alhashem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes

(2011) Yea Woon Kim et al.   NUCLEIC ACIDS RESEARCH

p66 -MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex

(2011) M. N. Gnanapragasam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

(2011) J. Xu et al.   SCIENCE

Genetic Therapy for Beta-Thalassemia: From the Bench to the Bedside

(2011) P. Arumugam et al.   Hematology-American Society of Hematology Education Program

The XmnI Gγ polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 β-thalassemia intermedia patients

(2010) Thi Khanh Tien Nguyen et al.   BLOOD CELLS MOLECULES AND DISEASES

Update on fetal hemoglobin gene regulation in hemoglobinopathies

(2010) Daniel E Bauer et al.   CURRENT OPINION IN PEDIATRICS

Transcriptional silencing of  -globin by BCL11A involves long-range interactions and cooperation with SOX6

(2010) J. Xu et al.   GENES & DEVELOPMENT

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

(2010) Marina Cavazzana-Calvo et al.   NATURE

Beta-thalassemia

(2010) Renzo Galanello et al.   Orphanet Journal of Rare Diseases

Molecular Analysis of γ-Globin Promoters, HS-111 and 3′HS1, in β-thalassemia Intermedia Patients Associated with High Levels of Hb F

(2009) Mohammad Hamid et al.   HEMOGLOBIN

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

(2009) S. L. Thein et al.   HUMAN MOLECULAR GENETICS

Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation

(2009) Reinhard Brunmeir et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Hemoglobin research and the origins of molecular medicine

(2008) A. N. Schechter   BLOOD

BP1 motif in the human β-globin promoter affects β-globin expression during embryonic/fetal erythropoiesis in transgenic mice bearing the human β-globin gene

(2008) Olga P. Zoueva et al.   BLOOD CELLS MOLECULES AND DISEASES

Silencing of A -Globin Gene Expression during Adult Definitive Erythropoiesis Mediated by GATA-1-FOG-1-Mi2 Complex Binding at the -566 GATA Site

(2008) S. Harju-Baker et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of transcriptional activator GATA-1 at human  -globin HS2

(2008) Y. Cho et al.   NUCLEIC ACIDS RESEARCH

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of  -thalassemia

(2008) M. Uda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A GATA-1-regulated microRNA locus essential for erythropoiesis

(2008) L. C. Dore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Genetic Association to Genetic Switch

(2008) Alan M. Michelson   SCIENCE

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A

(2008) Vijay G. Sankaran et al.   SCIENCE