Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation

Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene

(2015) Paul D. Ray et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

SUMOylation occurs in acute kidney injury and plays a cytoprotective role

(2015) Chunyuan Guo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression

(2015) Lan Shao et al.   Nature Communications

Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation

(2014) S Peuget et al.   CELL DEATH AND DIFFERENTIATION

Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription

(2014) Bhavana Chhunchha et al.   FEBS Journal

Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome

(2014) Y. Manevich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Small Ubiquitin-like Modifier (SUMO) Protein-specific Protease 1 De-SUMOylates Sharp-1 Protein and Controls Adipocyte Differentiation

(2014) Bingting Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

GPS-SUMO: a tool for the prediction of sumoylation sites and SUMO-interaction motifs

(2014) Qi Zhao et al.   NUCLEIC ACIDS RESEARCH

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Mutations of Asp540 and the domain-connecting residues synergistically enhance Pyrococcus furiosus DNA ligase activity

(2013) Maiko Tanabe et al.   FEBS LETTERS

SUMO: a (Oxidative) Stressed Protein

(2013) Marco Feligioni et al.   NEUROMOLECULAR MEDICINE

SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis

(2012) Markéta Častorálová et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response

(2012) Keiichi Ishihara et al.   FEBS Journal

Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics

(2012) Mark Larance et al.   MOLECULAR & CELLULAR PROTEOMICS

A Redox-Regulated SUMO/Acetylation Switch of HIPK2 Controls the Survival Threshold to Oxidative Stress

(2012) Laureano de la Vega et al.   MOLECULAR CELL

Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis

(2011) Nigar Fatma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Peroxiredoxin 6: A Bifunctional Enzyme with Glutathione Peroxidase and Phospholipase A2 Activities

(2010) Aron B. Fisher   ANTIOXIDANTS & REDOX SIGNALING

SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis

(2010) Luyang Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2activity

(2009) Yongzheng Wu et al.   BIOCHEMICAL JOURNAL

Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance

(2009) Liam T. Loftus et al.   BRAIN RESEARCH

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

(2009) Isao Fukuda et al.   CHEMISTRY & BIOLOGY

Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding

(2009) Shwu-Yuan Wu et al.   EMBO JOURNAL

PRDX6 attenuates oxidative stress- and TGFβ-induced abnormalities of human trabecular meshwork cells

(2009) Nigar Fatma et al.   FREE RADICAL RESEARCH

Sumoylation and human disease pathogenesis

(2009) Kevin D. Sarge et al.   TRENDS IN BIOCHEMICAL SCIENCES

TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity

(2008) Eri Kubo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

SnapShot: p53 Posttranslational Modifications

(2008) Jan-Philipp Kruse et al.   CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY