Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics

The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease

(2017) Christopher G. Bunick et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanosensing and Mechanotransduction at Cell–Cell Junctions

(2017) Alpha S. Yap et al.   Cold Spring Harbor Perspectives in Biology

Cross talk between the cytoplasm and nucleus during development and disease

(2016) Lori L Wallrath et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Integrin signalling regulates YAP and TAZ to control skin homeostasis

(2016) Ahmed Elbediwy et al.   DEVELOPMENT

Keratins Are Going Nuclear

(2016) Ryan P. Hobbs et al.   DEVELOPMENTAL CELL

E-cadherin-mediated force transduction signals regulate global cell mechanics

(2016) Ismaeel Muhamed et al.   JOURNAL OF CELL SCIENCE

Keratins K2 and K10 are essential for the epidermal integrity of plantar skin

(2016) Heinz Fischer et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo

(2016) Katrin Rietscher et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Yes-Associated Protein Contributes to the Development of Human Cutaneous Squamous Cell Carcinoma via Activation of RAS

(2016) Jinjing Jia et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interplay between Solo and keratin filaments is crucial for mechanical force–induced stress fiber reinforcement

(2016) Sachiko Fujiwara et al.   MOLECULAR BIOLOGY OF THE CELL

Arrhythmogenic cardiomyopathy

(2016) Kalliopi Pilichou et al.   Orphanet Journal of Rare Diseases

Structural basis of adhesive binding by desmocollins and desmogleins

(2016) Oliver J. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keratin network modifications lead to the mechanical stiffening of the hair follicle fiber

(2016) Thomas Bornschlögl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intermediate Filaments: Structure and Assembly

(2016) Harald Herrmann et al.   Cold Spring Harbor Perspectives in Biology

Tead and AP1 Coordinate Transcription and Motility

(2016) Xiangfan Liu et al.   Cell Reports

Structure of the Intermediate Filament-Binding Region of Desmoplakin

(2016) Hyunook Kang et al.   PLoS One

Effects of Plectin Depletion on Keratin Network Dynamics and Organization

(2016) Marcin Moch et al.   PLoS One

FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes

(2016) Takahisa Kuga et al.   Scientific Reports

Hepatocyte Growth Factor Activator Inhibitor Type 1 Maintains the Assembly of Keratin into Desmosomes in Keratinocytes by Regulating Protease-Activated Receptor 2–Dependent p38 Signaling

(2015) Makiko Kawaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

The S100 proteins in epidermis: Topology and function

(2015) Wiesława Leśniak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Desmosomes in acquired disease

(2015) Sara N. Stahley et al.   CELL AND TISSUE RESEARCH

An updated review of mechanotransduction in skin disorders: transcriptional regulators, ion channels, and microRNAs

(2015) Jing Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Remodeling of keratin-coupled cell adhesion complexes

(2015) Naël Osmani et al.   CURRENT OPINION IN CELL BIOLOGY

Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks

(2015) Sarah Köster et al.   CURRENT OPINION IN CELL BIOLOGY

PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding

(2015) Raymond Kwan et al.   HEPATOLOGY

The mechanotransduction machinery at work at adherens junctions

(2015) B. Ladoux et al.   Integrative Biology

Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin

(2015) Maeve A. McAleer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

GSK3- and PRMT-1–dependent modifications of desmoplakin control desmoplakin–cytoskeleton dynamics

(2015) Lauren V. Albrecht et al.   JOURNAL OF CELL BIOLOGY

A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes

(2015) Xia Feng et al.   JOURNAL OF CELL BIOLOGY

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

(2015) Vinod Kumar et al.   JOURNAL OF CELL BIOLOGY

The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes

(2015) F. V. Almeida et al.   JOURNAL OF CELL SCIENCE

p120-catenin controls contractility along the vertical axis of epithelial lateral membranes

(2015) Huapeng H. Yu et al.   JOURNAL OF CELL SCIENCE

14-3-3σ Regulates Keratinocyte Proliferation and Differentiation by Modulating Yap1 Cellular Localization

(2015) Sumitha A.T. Sambandam et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Distinct Impact of Two Keratin Mutations Causing Epidermolysis Bullosa Simplex on Keratinocyte Adhesion and Stiffness

(2015) Melanie Homberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Drosophila Model of Epidermolysis Bullosa Simplex

(2015) Jens Bohnekamp et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Yap/Taz gets under your skin

(2015) Eric O'Neill   Pigment Cell & Melanoma Research

Cadherin flexibility provides a key difference between desmosomes and adherens junctions

(2015) Humera Tariq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissection of keratin network formation, turnover and reorganization in living murine embryos

(2015) Nicole Schwarz et al.   Scientific Reports

Nucleocytoplasmic shuttling: a common theme in mechanotransduction

(2014) Amir S. Sharili et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanics of Individual Keratin Bundles in Living Cells

(2014) Jens-Friedrich Nolting et al.   BIOPHYSICAL JOURNAL

Loss of desmoglein 1 associated with palmoplantar keratoderma, dermatitis and multiple allergies

(2014) C. Has et al.   BRITISH JOURNAL OF DERMATOLOGY

Arrhythmogenic cardiomyopathy: a disease of intercalated discs

(2014) Martina Calore et al.   CELL AND TISSUE RESEARCH

Desmosomes in the Heart: A Review of Clinical and Mechanistic Analyses

(2014) Dipal M. Patel et al.   CELL COMMUNICATION AND ADHESION

Directed Expression of a Chimeric Type II Keratin Partially Rescues Keratin 5-null Mice

(2014) David M. Alvarado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different roles of cadherins in the assembly and structural integrity of the desmosome complex

(2014) Molly Lowndes et al.   JOURNAL OF CELL SCIENCE

Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers

(2014) A. R. Harris et al.   JOURNAL OF CELL SCIENCE

Loss of Keratin K2 Expression Causes Aberrant Aggregation of K10, Hyperkeratosis, and Inflammation

(2014) Heinz Fischer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interaction of Plectin with Keratins 5 and 14: Dependence on Several Plectin Domains and Keratin Quaternary Structure

(2014) Jamal-Eddine Bouameur et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Towards an accurate understanding of UHMWPE visco-dynamic behaviour for numerical modelling of implants

(2014) Federico Quinci et al.   Journal of the Mechanical Behavior of Biomedical Materials

Plakophilin 3 mediates Rap1-dependent desmosome assembly and adherens junction maturation

(2014) Viktor Todorovic´ et al.   MOLECULAR BIOLOGY OF THE CELL

Post-translational modifications of intermediate filament proteins: mechanisms and functions

(2014) Natasha T. Snider et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Desmosomes and the sodium channel complex: Implications for arrhythmogenic cardiomyopathy and Brugada syndrome

(2014) Marina Cerrone et al.   TRENDS IN CARDIOVASCULAR MEDICINE

A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes

(2014) Svitlana Kurinna et al.   Nature Communications

Force-dependent conformational switch of α-catenin controls vinculin binding

(2014) Mingxi Yao et al.   Nature Communications

The Small Heat Shock Protein Hsp27 Affects Assembly Dynamics and Structure of Keratin Intermediate Filament Networks

(2013) Jona Kayser et al.   BIOPHYSICAL JOURNAL

Regulation of cardiovascular connexins by mechanical forces and junctions

(2013) Merlijn J. Meens et al.   CARDIOVASCULAR RESEARCH

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

(2013) Suet Nee Chen et al.   CIRCULATION RESEARCH

The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development

(2013) Evan R Barry et al.   CURRENT OPINION IN CELL BIOLOGY

From tissue mechanics to transcription factors

(2013) Paul A. Janmey et al.   DIFFERENTIATION

Keratins control intercellular adhesion involving PKC-α–mediated desmoplakin phosphorylation

(2013) Cornelia Kröger et al.   JOURNAL OF CELL BIOLOGY

The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1

(2013) Adi D. Dubash et al.   JOURNAL OF CELL BIOLOGY

A novel mechanism of keratin cytoskeleton organization through casein kinase I  and FAM83H in colorectal cancer

(2013) T. Kuga et al.   JOURNAL OF CELL SCIENCE

Mechanosensitive systems at the cadherin-F-actin interface

(2013) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation

(2013) Robert M. Harmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Keratin 9 Is Required for the Structural Integrity and Terminal Differentiation of the Palmoplantar Epidermis

(2013) Dun Jack Fu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

YAP and TAZ Regulate Skin Wound Healing

(2013) Min-Jung Lee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin Fragility and Impaired Desmosomal Adhesion in Mice Lacking All Keratins

(2013) Janina Bär et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plakophilin-1 Protects Keratinocytes from Pemphigus Vulgaris IgG by Forming Calcium-Independent Desmosomes

(2013) Dana K. Tucker et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanistic Basis of Desmosome-Targeted Diseases

(2013) Caezar Al-Jassar et al.   JOURNAL OF MOLECULAR BIOLOGY

Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting

(2013) Liat Samuelov et al.   NATURE GENETICS

Keratins as the main component for the mechanical integrity of keratinocytes

(2013) L. Ramms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keratins significantly contribute to cell stiffness and impact invasive behavior

(2013) K. Seltmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Home sweet home: skin stem cell niches

(2012) Jill Goldstein et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration

(2012) Tomomi E. Kimura et al.   DEVELOPMENTAL BIOLOGY

Nrf2 links epidermal barrier function with antioxidant defense

(2012) Matthias Schäfer et al.   EMBO Molecular Medicine

Effects of keratin phosphorylation on the mechanical properties of keratin filaments in living cells

(2012) Giorgio Fois et al.   FASEB JOURNAL

Lack of Plakoglobin in Epidermis Leads to Keratoderma

(2012) Deqiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins

(2012) Laura Leitner et al.   JOURNAL OF CELL SCIENCE

Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity

(2012) L. Wallace et al.   JOURNAL OF CELL SCIENCE

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18

(2012) Wera Roth et al.   JOURNAL OF CELL SCIENCE

Keratin 16–Null Mice Develop Palmoplantar Keratoderma, a Hallmark Feature of Pachyonychia Congenita and Related Disorders

(2012) Juliane C. Lessard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Defining Keratin Protein Function in Skin Epithelia: Epidermolysis Bullosa Simplex and Its Aftermath

(2012) Pierre A. Coulombe et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Keratin Intracellular Concentration Revisited: Implications for Keratin Function in Surface Epithelia

(2012) Xia Feng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Direct evidence that PKCα positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness

(2012) Helen A Thomason et al.   JOURNAL OF PATHOLOGY

Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium

(2012) Kaelyn D. Sumigray et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis for heteromeric assembly and perinuclear organization of keratin filaments

(2012) Chang-Hun Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration

(2011) Mei Yang et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

A Mechanoresponsive Cadherin-Keratin Complex Directs Polarized Protrusive Behavior and Collective Cell Migration

(2011) Gregory F. Weber et al.   DEVELOPMENTAL CELL

Lack of plakoglobin leads to lethal congenital epidermolysis bullosa: a novel clinico-genetic entity

(2011) Manuela Pigors et al.   HUMAN MOLECULAR GENETICS

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia

(2011) Reinhard Windoffer et al.   JOURNAL OF CELL BIOLOGY

Desmoglein as a Target in Skin Disease and Beyond

(2011) Masayuki Amagai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Desmoplakin Regulates Desmosome Hyperadhesion

(2011) Ryan P. Hobbs et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Crystal Structure of a Rigid Four-Spectrin-Repeat Fragment of the Human Desmoplakin Plakin Domain

(2011) Hee-Jung Choi et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

(2011) Cory L. Simpson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Desmosomes: adhesive strength and signalling in health and disease

(2010) Helen A. Thomason et al.   BIOCHEMICAL JOURNAL

Induction of p38, tumour necrosis factor-α and RANTES by mechanical stretching of keratinocytes expressing mutant keratin 10R156H

(2010) M. Obarzanek-Fojt et al.   BRITISH JOURNAL OF DERMATOLOGY

E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly

(2010) Prajakta Gosavi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The hippo pathway in biological control and cancer development

(2010) Siew Wee Chan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Desmosome Disassembly in Response to Pemphigus Vulgaris IgG Occurs in Distinct Phases and Can Be Reversed by Expression of Exogenous Dsg3

(2010) Jean M. Jennings et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plakophilin 2 Couples Actomyosin Remodeling to Desmosomal Plaque Assembly via RhoA

(2010) Lisa M. Godsel et al.   MOLECULAR BIOLOGY OF THE CELL

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Autoimmune and infectious skin diseases that target desmogleins

(2010) Masayuki AMAGAI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Single cell mechanics of keratinocyte cells

(2010) Valentin Lulevich et al.   ULTRAMICROSCOPY

Ectodermal Dysplasia-Skin Fragility Syndrome

(2009) John A. McGrath et al.   DERMATOLOGIC CLINICS

Insights into the mechanical properties of epithelial cells: the effects of shear stress on the assembly and remodeling of keratin intermediate filaments

(2009) Eric W. Flitney et al.   FASEB JOURNAL

Self-organization of keratin intermediate filaments into cross-linked networks

(2009) Chang-Hun Lee et al.   JOURNAL OF CELL BIOLOGY

Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor

(2009) Preethi Vijayaraj et al.   JOURNAL OF CELL BIOLOGY

Wound repair at a glance

(2009) T. J. Shaw et al.   JOURNAL OF CELL SCIENCE

Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice

(2009) Heidi Koegel et al.   JOURNAL OF CLINICAL INVESTIGATION

Intermediate filaments: primary determinants of cell architecture and plasticity

(2009) Harald Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Shear Stress Induced Reorganization of the Keratin Intermediate Filament Network Requires Phosphorylation by Protein Kinase C ζ

(2009) Sivaraj Sivaramakrishnan et al.   MOLECULAR BIOLOGY OF THE CELL

Intercellular Junction Assembly, Dynamics, and Homeostasis

(2009) K. J. Green et al.   Cold Spring Harbor Perspectives in Biology

The Elastic Properties of the Structurally Characterized Myosin II S2 Subdomain: A Molecular Dynamics and Normal Mode Analysis

(2008) Ivana Adamovic et al.   BIOPHYSICAL JOURNAL

The human keratins: biology and pathology

(2008) Roland Moll et al.   HISTOCHEMISTRY AND CELL BIOLOGY

p120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+medium but not when disassembled in low-Ca2+medium in DJM-1 cells

(2008) Miho KANNO et al.   JOURNAL OF DERMATOLOGY

Plakoglobin Is Required for Effective Intermediate Filament Anchorage to Desmosomes

(2008) Devrim Acehan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Desmosome structure, composition and function

(2007) David Garrod et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Vibrissa hair bulge houses two populations of skin epithelial stem cells distinct by their keratin profile

(2007) Danielle Larouche et al.   FASEB JOURNAL

The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases

(2007) Ildiko Szeverenyi et al.   HUMAN MUTATION

Plakophilin-3-Deficient Mice Develop Hair Coat Abnormalities and Are Prone to Cutaneous Inflammation

(2007) Tatyana Sklyarova et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY