Regulating the Suprachiasmatic Nucleus (SCN) Circadian Clockwork: Interplay between Cell-Autonomous and Circuit-Level Mechanisms

Membrane Currents, Gene Expression, and Circadian Clocks

(2017) Charles N. Allen et al.   Cold Spring Harbor Perspectives in Biology

Cellular Timekeeping: It’s Redox o’Clock

(2017) Nikolay B. Milev et al.   Cold Spring Harbor Perspectives in Biology

Design Principles of Phosphorylation-Dependent Timekeeping in Eukaryotic Circadian Clocks

(2017) Koji L. Ode et al.   Cold Spring Harbor Perspectives in Biology

Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking

(2016) Stefania Militi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporally chimeric mice reveal flexibility of circadian period-setting in the suprachiasmatic nucleus

(2016) Nicola J. Smyllie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional network inference of the suprachiasmatic nucleus

(2016) John H. Abel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling

(2016) Mathew D. Edwards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous Drosophila circadian pacemakers display nonsynchronous Ca2+ rhythms in vivo

(2016) X. Liang et al.   SCIENCE

BK channel inactivation gates daytime excitability in the circadian clock

(2016) Joshua P. Whitt et al.   Nature Communications

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis

(2015) Michael J. Parsons et al.   CELL

A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability

(2015) Matthieu Flourakis et al.   CELL

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation

(2015) Jonathan O. Lipton et al.   CELL

Localization and expression of GABA transporters in the suprachiasmatic nucleus

(2015) Michael Moldavan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Circadian Period of PER2 Expression in the Suprachiasmatic Nucleus

(2015) Daniel Granados-Fuentes et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Circadian Rhythmicity of Active GSK3 Isoforms Modulates Molecular Clock Gene Rhythms in the Suprachiasmatic Nucleus

(2015) Rachel C. Besing et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Vasoactive Intestinal Polypeptide (VIP)-Expressing Neurons in the Suprachiasmatic Nucleus Provide Sparse GABAergic Outputs to Local Neurons with Circadian Regulation Occurring Distal to the Opening of Postsynaptic GABAA Ionotropic Receptors

(2015) J. Fan et al.   JOURNAL OF NEUROSCIENCE

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

(2015) Min Zhou et al.   MOLECULAR CELL

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

(2015) Ruifeng Cao et al.   NATURE NEUROSCIENCE

Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior

(2015) Jeff R Jones et al.   NATURE NEUROSCIENCE

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms

(2015) Ivan T. Lee et al.   NEURON

Cellular Clocks in AVP Neurons of the SCN Are Critical for Interneuronal Coupling Regulating Circadian Behavior Rhythm

(2015) Michihiro Mieda et al.   NEURON

GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time

(2015) Jihwan Myung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping

(2015) Daniel DeWoskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Influencing circadian and sleep-wake regulation for prevention and intervention in mood and anxiety disorders: what makes a good homeostat?

(2014) Ellen Frank et al.   Annals of the New York Academy of Sciences

A Novel Mechanism Controlling Resetting Speed of the Circadian Clock to Environmental Stimuli

(2014) Violetta Pilorz et al.   CURRENT BIOLOGY

Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture

(2014) Xiao Yu et al.   CURRENT BIOLOGY

Differential contributions of intra-cellular and inter-cellular mechanisms to the spatial and temporal architecture of the suprachiasmatic nucleus circadian circuitry in wild-type, cryptochrome-null and vasoactive intestinal peptide receptor 2-null mutant

(2014) S. Pauls et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Circadian behavior is light-reprogrammed by plastic DNA methylation

(2014) Abdelhalim Azzi et al.   NATURE NEUROSCIENCE

Light as a central modulator of circadian rhythms, sleep and affect

(2014) Tara A. LeGates et al.   NATURE REVIEWS NEUROSCIENCE

Seasonal induction of GABAergic excitation in the central mammalian clock

(2014) Sahar Farajnia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock

(2014) Peter C. St. John et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing

(2014) F. Fernandez et al.   SCIENCE

Lhx1 Controls Terminal Differentiation and Circadian Function of the Suprachiasmatic Nucleus

(2014) Joseph L. Bedont et al.   Cell Reports

Circadian clocks, brain function, and development

(2013) Ellen Frank et al.   Annals of the New York Academy of Sciences

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock

(2013) Aarti Jagannath et al.   CELL

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks

(2013) C. Saini et al.   GENES & DEVELOPMENT

Clock and Light Regulation of the CREB Coactivator CRTC1 in the Suprachiasmatic Circadian Clock

(2013) K. Sakamoto et al.   JOURNAL OF NEUROSCIENCE

Distinct and Separable Roles for Endogenous CRY1 and CRY2 within the Circadian Molecular Clockwork of the Suprachiasmatic Nucleus, as Revealed by the Fbxl3Afh Mutation

(2013) S. N. Anand et al.   JOURNAL OF NEUROSCIENCE

A Gq-Ca2+ Axis Controls Circuit-Level Encoding of Circadian Time in the Suprachiasmatic Nucleus

(2013) Marco Brancaccio et al.   NEURON

GABA Networks Destabilize Genetic Oscillations in the Circadian Pacemaker

(2013) G. Mark Freeman et al.   NEURON

Dynamic Interactions Mediated by Nonredundant Signaling Mechanisms Couple Circadian Clock Neurons

(2013) Jennifer A. Evans et al.   NEURON

Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling

(2013) Ruifeng Cao et al.   NEURON

Analysis of core circadian feedback loop in suprachiasmatic nucleus ofmCry1-luctransgenic reporter mouse

(2013) Elizabeth S. Maywood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A neuropeptide speeds circadian entrainment by reducing intercellular synchrony

(2013) S. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag

(2013) Yoshiaki Yamaguchi et al.   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus

(2013) Daisuke Ono et al.   Nature Communications

Genetic basis of human circadian rhythm disorders

(2012) Christopher R. Jones et al.   EXPERIMENTAL NEUROLOGY

IA Channels Encoded by Kv1.4 and Kv4.2 Regulate Neuronal Firing in the Suprachiasmatic Nucleus and Circadian Rhythms in Locomotor Activity

(2012) D. Granados-Fuentes et al.   JOURNAL OF NEUROSCIENCE

Period Coding of Bmal1 Oscillators in the Suprachiasmatic Nucleus

(2012) J. Myung et al.   JOURNAL OF NEUROSCIENCE

Peroxiredoxins are conserved markers of circadian rhythms

(2012) Rachel S. Edgar et al.   NATURE

Subcortical Visual Shell Nuclei Targeted by ipRGCs Develop from a Sox14+-GABAergic Progenitor and Require Sox14 to Regulate Daily Activity Rhythms

(2012) Alessio Delogu et al.   NEURON

Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus

(2012) R. Enoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of  -Amyloid in Mice with Alzheimer's Disease Pathology

(2012) J. H. Roh et al.   Science Translational Medicine

Weakly Circadian Cells Improve Resynchrony

(2012) Alexis B. Webb et al.   PLoS Computational Biology

Effect of Network Architecture on Synchronization and Entrainment Properties of the Circadian Oscillations in the Suprachiasmatic Nucleus

(2012) Marc Hafner et al.   PLoS Computational Biology

Modeling the Seasonal Adaptation of Circadian Clocks by Changes in the Network Structure of the Suprachiasmatic Nucleus

(2012) Christian Bodenstein et al.   PLoS Computational Biology

Multicellular Model for Intercellular Synchronization in Circadian Neural Networks

(2011) Christina Vasalou et al.   BIOPHYSICAL JOURNAL

Wavelet Measurement Suggests Cause of Period Instability in Mammalian Circadian Neurons

(2011) Kirsten Meeker et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Cyclic AMP Signaling Control of Action Potential Firing Rate and Molecular Circadian Pacemaking in the Suprachiasmatic Nucleus

(2011) Susan E. Atkinson et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Vasoactive intestinal polypeptide requires parallel changes in adenylate cyclase and phospholipase C to entrain circadian rhythms to a predictable phase

(2011) Sungwon An et al.   JOURNAL OF NEUROPHYSIOLOGY

Tuning the Period of the Mammalian Circadian Clock: Additive and Independent Effects of CK1 Tau and Fbxl3Afh Mutations on Mouse Circadian Behavior and Molecular Pacemaking

(2011) E. S. Maywood et al.   JOURNAL OF NEUROSCIENCE

Linking neural activity and molecular oscillations in the SCN

(2011) Christopher S. Colwell   NATURE REVIEWS NEUROSCIENCE

Development of melanopsin-based irradiance detecting circuitry

(2011) David S McNeill et al.   Neural Development

AMPK Regulates Circadian Rhythms in a Tissue- and Isoform-Specific Manner

(2011) Jee-Hyun Um et al.   PLoS One

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

(2011) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits

(2011) E. S. Maywood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1

(2011) H.-m. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus

(2011) Masao Doi et al.   Nature Communications

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Dual-Color Luciferase Mouse Directly Demonstrates Coupled Expression of Two Clock Genes

(2010) Takako Noguchi et al.   BIOCHEMISTRY

Rhythm-Promoting Actions of Exercise in Mice with Deficient Neuropeptide Signaling

(2010) A. Power et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Casein Kinase 1 Delta (CK1δ) Regulates Period Length of the Mouse Suprachiasmatic Circadian Clock In Vitro

(2010) Jean-Pierre Etchegaray et al.   PLoS One

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

(2010) Q.-J. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

(2010) E. D. Buhr et al.   SCIENCE

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

(2010) Tsuyoshi Hirota et al.   PLOS BIOLOGY

Emergence of Noise-Induced Oscillations in the Central Circadian Pacemaker

(2010) Caroline H. Ko et al.   PLOS BIOLOGY

Proteomic Analysis Reveals the Role of Synaptic Vesicle Cycling in Sustaining the Suprachiasmatic Circadian Clock

(2009) Michael J. Deery et al.   CURRENT BIOLOGY

Selective Inhibition of Casein Kinase 1  Minimally Alters Circadian Clock Period

(2009) K. M. Walton et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neurons

(2009) A. B. Webb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A model of the cell-autonomous mammalian circadian clock

(2009) H. P. Mirsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Quantification of Circadian Rhythms in Single Cells

(2009) Pål O. Westermark et al.   PLoS Computational Biology

Global parameter search reveals design principles of the mammalian circadian clock

(2008) James CW Locke et al.   BMC Systems Biology

The Meter of Metabolism

(2008) Carla B. Green et al.   CELL

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

(2008) Qing-Jun Meng et al.   NEURON

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3 

(2008) T. Hirota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA