Synthesis, structure–activity relationship and binding mode analysis of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

(2016) David B. Sykes et al.   CELL

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

(2016) Sreekanth Kokkonda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

(2015) Hélène Munier-Lehmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase

(2015) Junsheng Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

(2015) Marianne Lucas-Hourani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity

(2015) Shiliang Li et al.   Scientific Reports

Teriflunomide for the Treatment of Relapsing Multiple Sclerosis

(2014) Luigi Brunetti et al.   ANNALS OF PHARMACOTHERAPY

Teriflunomide and Its Mechanism of Action in Multiple Sclerosis

(2014) Amit Bar-Or et al.   DRUGS

4-Thiazolidinones: The advances continue…

(2013) Avinash C. Tripathi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Safety evaluation of leflunomide in rheumatoid arthritis

(2013) Helen I Keen et al.   Expert Opinion On Drug Safety

On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses

(2013) Hélène Munier-Lehmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study

(2012) K.R. Herrlinger et al.   Journal of Crohns & Colitis

5-Arylidene-4-Thiazolidinone Derivatives Active as Antidegenerative Agents on Human Chondrocyte Cultures

(2012) Annamaria Panico et al.   Medicinal Chemistry

The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells

(2012) Edmond F. O’Donnell et al.   PLoS One

Fragment-based design, docking, synthesis, biological evaluation and structure–activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors

(2011) Phaedra Eleftheriou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors

(2011) V. K. Vyas et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Leflunomide for cytomegalovirus: bench to bedside

(2011) B. Chacko et al.   Transplant Infectious Disease

HRCT-proven leflunomide pneumonitis in a patient with psoriatic arthritis and normal lung function tests and chest radiography

(2010) M. A. Lee et al.   RHEUMATOLOGY

The Structures of Human Dihydroorotate Dehydrogenase with and without Inhibitor Reveal Conformational Flexibility in the Inhibitor and Substrate Binding Sites†

(2008) Björn Walse et al.   BIOCHEMISTRY

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-Thiazolidinone – A biologically active scaffold

(2007) Amit Verma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY