Controlled inhibition of methyltransferases using photoswitchable peptidomimetics: towards an epigenetic regulation of leukemia

Emerging Targets in Photopharmacology

(2016) Michael M. Lerch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Azobenzene photocontrol of peptides and proteins

(2016) Robert J. Mart et al.   CHEMICAL COMMUNICATIONS

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes

(2016) Nilda L. Alicea-Velázquez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light-controlled modulation of gene expression by chemical optoepigenetic probes

(2016) Surya A Reis et al.   Nature Chemical Biology

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia

(2016) Y Hu et al.   ONCOGENE

MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program

(2016) Jing Xu et al.   Cell Discovery

Red-Shifting Azobenzene Photoswitches for in Vivo Use

(2015) Mingxin Dong et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Roadmap to Success in Photopharmacology

(2015) Johannes Broichhagen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Reading the Combinatorial Histone Language

(2015) Zhangli Su et al.   ACS Chemical Biology

Optical Control of Insulin Secretion Using an Incretin Switch

(2015) Johannes Broichhagen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulating protein–protein interactions: the potential of peptides

(2015) Laura Nevola et al.   CHEMICAL COMMUNICATIONS

Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy

(2015) Wiktor Szymanski et al.   CHEMISTRY-A EUROPEAN JOURNAL

Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond

(2015) Chun-Wei Chen et al.   EXPERIMENTAL HEMATOLOGY

A systematic description of MLL fusion gene formation

(2014) Rebecca L. Wright et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia

(2014) Bin E. Li et al.   EXPERIMENTAL HEMATOLOGY

Photopharmacology: Beyond Proof of Principle

(2014) Willem A. Velema et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia

(2014) Fang Cao et al.   MOLECULAR CELL

Illuminating cell signalling with optogenetic tools

(2014) Doug Tischer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Azobenzenes in a New Light-Switching In Vivo

(2012) Hermann A. Wegner   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lighting up with azobenzenes

(2012) G. Andrew Woolley   Nature Chemistry

Fluorescence Imaging of Azobenzene Photoswitching In Vivo

(2011) Andrew A. Beharry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Azobenzene: An Optical Switch for in vivo Experiments

(2011) Josef Wachtveitl et al.   CHEMBIOCHEM

Photoisomerization in different classes of azobenzene

(2011) H. M. Dhammika Bandara et al.   CHEMICAL SOCIETY REVIEWS

The Language of Histone Crosstalk

(2010) Jung-Shin Lee et al.   CELL

Mixed lineage leukemia: a structure-function perspective of the MLL1 protein

(2010) Michael S. Cosgrove et al.   FEBS Journal

Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1−WDR5 Interaction

(2010) Hacer Karatas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

Controlling the Brain with Light

(2010) Karl Deisseroth   SCIENTIFIC AMERICAN

Corrigendum to “Azobenzenes—synthesis and carbohydrate applications” [Tetrahedron 65 (49) (2008) 10105–10123]

(2010) Florian Hamon et al.   TETRAHEDRON

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

(2009) Daniel A. Lim et al.   NATURE

Structure of WDR5 Bound to Mixed Lineage Leukemia Protein-1 Peptide

(2008) Anamika Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket

(2008) Ji-Joon Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY