Light-controlled modulation of gene expression by chemical optoepigenetic probes

Photoswitchable fatty acids enable optical control of TRPV1

(2015) James Allen Frank et al.   Nature Communications

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

(2014) Johannes Gräff et al.   CELL

Epigenetic control and the circadian clock: Linking metabolism to neuronal responses

(2014) R. Orozco-Solis et al.   NEUROSCIENCE

The Potential of HDAC Inhibitors as Cognitive Enhancers

(2013) Johannes Gräff et al.   Annual Review of Pharmacology and Toxicology

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

(2013) Benjamin E. L. Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polypharmacology – Foe or Friend?

(2013) Jens-Uwe Peters   JOURNAL OF MEDICINAL CHEMISTRY

Optical control of mammalian endogenous transcription and epigenetic states

(2013) Silvana Konermann et al.   NATURE

Optogenetic pharmacology for control of native neuronal signaling proteins

(2013) Richard H Kramer et al.   NATURE NEUROSCIENCE

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

(2013) Frederick A. Schroeder et al.   PLoS One

Light-Controlled Tools

(2012) Clara Brieke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Optochemical Genetics

(2011) Timm Fehrentz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

Azobenzene photoswitches for biomolecules

(2011) Andrew A. Beharry et al.   CHEMICAL SOCIETY REVIEWS

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity

(2011) Stephen J. Haggarty et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

GeneMANIA Cytoscape plugin: fast gene function predictions on the desktop

(2010) J. Montojo et al.   BIOINFORMATICS

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Kinetico-Mechanistic Study of the Thermal Cis-to-Trans Isomerization of 4,4′-Dialkoxyazoderivatives in Nematic Liquid Crystals

(2010) Jaume Garcia-Amorós et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Chemical phylogenetics of histone deacetylases

(2010) James E Bradner et al.   Nature Chemical Biology

Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions

(2009) Aleksandr V. Marenich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors

(2008) David M. Andrews et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS