Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

(2017) Divya Prakash Gnanadhas et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models

(2017) Chaoran Yin et al.   MOLECULAR THERAPY

Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes

(2017) Myosotys Rodriguez et al.   Viruses-Basel

Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

(2017) Myosotys Rodriguez et al.   Scientific Reports

Epigenetic and transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   Autophagy

Advancements in nano-enabled therapeutics for neuroHIV management

(2016) Ajeet Kaushik et al.   International Journal of Nanomedicine

Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro

(2016) Myosotys Rodriguez et al.   Journal of Neuroimmune Pharmacology

The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy

(2016) Gang Zhang et al.   Nanomedicine-Nanotechnology Biology and Medicine

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

The role of autophagy in modulation of neuroinflammation in microglia

(2016) P. Su et al.   NEUROSCIENCE

Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics

(2016) Ankit Shah et al.   NEUROTOXICITY RESEARCH

Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport

(2016) Pablo Mardones et al.   Science Signaling

Methamphetamine potentiates HIV-1 gp120-mediated autophagy via Beclin-1 and Atg5/7 as a pro-survival response in astrocytes

(2016) Lu Cao et al.   Cell Death & Disease

Accelerated oral nanomedicine discovery from miniaturized screening to clinical production exemplified by paediatric HIV nanotherapies

(2016) Marco Giardiello et al.   Nature Communications

Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport

(2016) Pablo Mardones et al.   Science Signaling

Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity

(2016) Aram Nikolai Andersen et al.   Frontiers in Immunology

Targeting the Brain Reservoirs: Toward an HIV Cure

(2016) Céline Marban et al.   Frontiers in Immunology

HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy

(2015) Sophie Borel et al.   AIDS

HIV-1 Nef blocks autophagy in human astrocytes

(2015) Luca Sardo et al.   CELL CYCLE

Dysregulation of autophagy by HIV-1 Nef in human astrocytes

(2015) A Sami Saribas et al.   CELL CYCLE

Central Nervous System Penetration of Antiretroviral Drugs: Pharmacokinetic, Pharmacodynamic and Pharmacogenomic Considerations

(2015) Eric H. Decloedt et al.   CLINICAL PHARMACOKINETICS

Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA

(2015) Gavin C. Sampey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 differentially modulates autophagy in neurons and astrocytes

(2015) Rajeev Mehla et al.   JOURNAL OF NEUROIMMUNOLOGY

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

HIV reservoirs: what, where and how to target them

(2015) Melissa J. Churchill et al.   NATURE REVIEWS MICROBIOLOGY

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

(2015) Alonso Heredia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in Huntington disease and huntingtin in autophagy

(2015) Dale D.O. Martin et al.   TRENDS IN NEUROSCIENCES

Viruses and the autophagy pathway

(2015) William T. Jackson   VIROLOGY

The Tat Inhibitor Didehydro-Cortistatin A Prevents HIV-1 Reactivation from Latency

(2015) Guillaume Mousseau et al.   mBio

About-face on the metabolic side effects of rapamycin

(2015) Adam B. Salmon   Oncotarget

Autophagy restricts HIV-1 infection

(2015) Coralie F. Daussy et al.   Oncotarget

RNA interference approaches for treatment of HIV-1 infection

(2015) Maggie L Bobbin et al.   Genome Medicine

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

(2015) Grant R. Campbell et al.   PLoS Pathogens

HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission

(2015) Mykola Pinkevych et al.   PLoS Pathogens

Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure

(2015) Seth M. Dever et al.   Frontiers in Microbiology

HIV-1 gp41 fusogenic function triggers autophagy in uninfected cells

(2014) Mélanie Denizot et al.   Autophagy

Decreased neuronal autophagy in HIV dementia: A mechanism of indirect neurotoxicity

(2014) Mehrdad Alirezaei et al.   Autophagy

Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation

(2014) Bo Liu et al.   Autophagy

Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients

(2014) Roberta Nardacci et al.   Autophagy

HIV-1 Tat protein induces glial cell autophagy through enhancement of BAG3 protein levels

(2014) Anna Paola Bruno et al.   CELL CYCLE

Phosphoprotein of Human Parainfluenza Virus Type 3 Blocks Autophagosome-Lysosome Fusion to Increase Virus Production

(2014) Binbin Ding et al.   Cell Host & Microbe

A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability

(2014) Rupert Beale et al.   Cell Host & Microbe

Brain Inflammation is a Common Feature of HIV-Infected Patients without HIV Encephalitis or Productive Brain Infection

(2014) Eleonora Tavazzi et al.   CURRENT HIV RESEARCH

Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia

(2014) N. Yuan et al.   HAEMATOLOGICA

Roles of autophagy in HIV infection

(2014) Christina Dinkins et al.   IMMUNOLOGY AND CELL BIOLOGY

Targeting γ-Herpesvirus 68 Bcl-2-mediated Down-regulation of Autophagy

(2014) Minfei Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Induction by Histone Deacetylase Inhibitors Inhibits HIV Type 1

(2014) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epstein-Barr Virus Blocks the Autophagic Flux and Appropriates the Autophagic Machinery To Enhance Viral Replication

(2014) M. Granato et al.   JOURNAL OF VIROLOGY

Autophagy Restricts HIV-1 Infection by Selectively Degrading Tat in CD4+T Lymphocytes

(2014) Sophie Sagnier et al.   JOURNAL OF VIROLOGY

HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse

(2014) Nazira El-Hage et al.   JOURNAL OF VIROLOGY

Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via the Extracellular Signal-Regulated Kinase Pathway

(2014) C.-H. Hung et al.   JOURNAL OF VIROLOGY

Novel HIV-1 MiRNAs Stimulate TNFα Release in Human Macrophages via TLR8 Signaling Pathway

(2014) Mark A. Bernard et al.   PLoS One

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human Immunodeficiency Virus-1 (HIV-1)-Mediated Apoptosis: New Therapeutic Targets

(2014) Zukile Mbita et al.   Viruses-Basel

Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness

(2014) Francesc Baixauli et al.   Frontiers in Immunology

Application and interpretation of current autophagy inhibitors and activators

(2013) Ya-ping Yang et al.   ACTA PHARMACOLOGICA SINICA

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Inhibition of human immunodeficiency virus type-1 through autophagy

(2013) Grant R Campbell et al.   CURRENT OPINION IN MICROBIOLOGY

Inflammatory Bowel Disease: Dysfunction of Autophagy?

(2013) Michael Scharl et al.   DIGESTIVE DISEASES

Exosomes Derived from HIV-1-infected Cells Contain Trans-activation Response Element RNA

(2013) Aarthi Narayanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The New Small-Molecule Mixed-Lineage Kinase 3 Inhibitor URMC-099 Is Neuroprotective and Anti-Inflammatory in Models of Human Immunodeficiency Virus-Associated Neurocognitive Disorders

(2013) D. F. Marker et al.   JOURNAL OF NEUROSCIENCE

Hepatitis B virus x protein induces autophagyviaactivating death-associated protein kinase

(2013) H.-T Zhang et al.   JOURNAL OF VIRAL HEPATITIS

Equivalent Benefit of Rapamycin and a Potent mTOR ATP-Competitive Inhibitor, MLN0128 (INK128), in a Mouse Model of Tuberous Sclerosis

(2013) Yanan Guo et al.   MOLECULAR CANCER RESEARCH

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada

(2013) Hasina Samji et al.   PLoS One

Reactivation of latent HIV by histone deacetylase inhibitors

(2013) Kotaro Shirakawa et al.   TRENDS IN MICROBIOLOGY

Divergent Roles of Autophagy in Virus Infection

(2013) Abhilash Chiramel et al.   Cells

Autophagy in astrocytes

(2012) Chiara Di Malta et al.   Autophagy

Autophagy induction by vitamin D inhibits bothMycobacterium tuberculosisand human immunodeficiency virus type 1

(2012) Grant R. Campbell et al.   Autophagy

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sequences within RNA coding for HIV-1 Gag p17 are efficiently targeted to exosomes

(2012) Sandra Columba Cabezas et al.   CELLULAR MICROBIOLOGY

HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells

(2012) Xue Wang et al.   CELLULAR SIGNALLING

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN

(2012) Partab Rai et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The Herpes Simplex Virus 1 Us11 Protein Inhibits Autophagy through Its Interaction with the Protein Kinase PKR

(2012) M. Lussignol et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling

(2012) Shubham Shrivastava et al.   JOURNAL OF VIROLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Chloroquine-Mediated Lysosomal Dysfunction Enhances the Anticancer Effect of Nutrient Deprivation

(2012) Ljubica Harhaji-Trajkovic et al.   PHARMACEUTICAL RESEARCH

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors

(2012) Julia JM Eekels et al.   Virology Journal

Vitamin D Inhibits Human Immunodeficiency Virus Type 1 and Mycobacterium tuberculosis Infection in Macrophages through the Induction of Autophagy

(2012) Grant R. Campbell et al.   PLoS Pathogens

Brain Cell Reservoirs of Latent Virus in Presymptomatic HIV-Infected Individuals

(2011) Katherine A. Thompson et al.   AMERICAN JOURNAL OF PATHOLOGY

Autophagy promotes the replication of encephalomyocarditis virus in host cells

(2011) Yongning Zhang et al.   Autophagy

Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway

(2011) Yi Mao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Low Vitamin D among HIV-Infected Adults: Prevalence of and Risk Factors for Low Vitamin D Levels in a Cohort of HIV-Infected Adults and Comparison to Prevalence among Adults in the US General Population

(2011) C. N. Dao et al.   CLINICAL INFECTIOUS DISEASES

Hormonally Active Vitamin D3 (1α,25-Dihydroxycholecalciferol) Triggers Autophagy in Human Macrophages That Inhibits HIV-1 Infection

(2011) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

(2011) Jamie M. Ireland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy Is Increased in Postmortem Brains of Persons With HIV-1-Associated Encephalitis

(2011) Dejiang Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy

(2011) W.-C. Su et al.   JOURNAL OF VIROLOGY

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Complex Inhibitory Effects of Nitric Oxide on Autophagy

(2011) Sovan Sarkar et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study

(2011) S Shen et al.   ONCOGENE

An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice

(2011) C. P. Neff et al.   Science Translational Medicine

Chikungunya triggers an autophagic process which promotes viral replication

(2011) Pascale Krejbich-Trotot et al.   Virology Journal

Beclin-1 Targeting for Viral Immune Escape

(2011) Christian Münz   Viruses-Basel

HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction

(2010) James CB Li et al.   AIDS

HIV Type 1 Nef Is Released from Infected Cells in CD45+ Microvesicles and Is Present in the Plasma of HIV-Infected Individuals

(2010) A.D. Raymond et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

TSG101: A Novel Anti-HIV-1 Drug Target

(2010) Hongfei Chen et al.   CURRENT MEDICINAL CHEMISTRY

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

HIV-1 Inhibits Autophagy in Bystander Macrophage/Monocytic Cells through Src-Akt and STAT3

(2010) Jennifer Van Grol et al.   PLoS One

Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection

(2010) Carl Guévin et al.   VIROLOGY

Introduction: challenges to finding a cure for HIV infection

(2010) Douglas D Richman   Current Opinion in HIV and AIDS

Histone deacetylase inhibitors and HIV latency

(2010) David M Margolis   Current Opinion in HIV and AIDS

Human immunodeficiency virus type-1 infection inhibits autophagy

(2009) Dejiang Zhou et al.   AIDS

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

(2009) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Novel HIV-1 therapeutics through targeting altered host cell pathways

(2009) William Coley et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

HIV uses autophagy for its own means

(2009) Nicole LeBrasseur   JOURNAL OF CELL BIOLOGY

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Simian Virus 40 Small T Antigen Activates AMPK and Triggers Autophagy To Protect Cancer Cells from Nutrient Deprivation

(2009) S. H. Kumar et al.   JOURNAL OF VIROLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Differential Role of Autophagy in CD4 T Cells and Macrophages during X4 and R5 HIV-1 Infection

(2009) Lucile Espert et al.   PLoS One

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway

(2008) N. Izquierdo-Useros et al.   BLOOD

Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression

(2008) Hong Tang et al.   HEPATOLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration

(2008) Mehrdad Alirezaei et al.   PLoS One

Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

(2008) Bonsu Ku et al.   PLoS Pathogens

Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1

(2008) A. Heredia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy Is Essential for Preimplantation Development of Mouse Embryos

(2008) S. Tsukamoto et al.   SCIENCE