Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway

The PI3K/AKT Pathway as a Target for Cancer Treatment

(2016) Ingrid A. Mayer et al.   Annual Review of Medicine

Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy

(2016) Dahong Yao et al.   APOPTOSIS

Necroptosis: A new way of dying?

(2016) Britt Hanson   CANCER BIOLOGY & THERAPY

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(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

APPL1-mediated activation of STAT3 contributes to inhibitory effect of adiponectin on hepatic gluconeogenesis

(2016) Youming Ding et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation

(2016) Feng Guan et al.   PLoS One

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

(2015) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

PI3K and AKT: Unfaithful Partners in Cancer

(2015) Seraina Faes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis

(2015) Saroj Nepal et al.   Oncotarget

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells

(2014) Bérangère Lucotte et al.   MOLECULAR NEUROBIOLOGY

Simultaneous activation of mitophagy and autophagy by staurosporine protects against dopaminergic neuronal cell death

(2014) Ji-Young Ha et al.   NEUROSCIENCE LETTERS

Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level

(2014) ZONGQUAN XU et al.   ONCOLOGY REPORTS

Activation of the PI3K/mTOR/AKT Pathway and Survival in Solid Tumors: Systematic Review and Meta-Analysis

(2014) Alberto Ocana et al.   PLoS One

Staurosporine analogs promote distinct patterns of process outgrowth and polyploidy in small cell lung carcinoma cells

(2014) Hichem Gallala et al.   TUMOR BIOLOGY

Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways

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The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

Staurosporine is chemoprotective by inducing G 1 arrest in a Chk1- and pRb-dependent manner

(2013) Mollianne McGahren Murray et al.   CARCINOGENESIS

MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability

(2013) XIN LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in human hepatocarcinoma cell lines

(2013) Chao Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells

(2012) Cuihong Zhou et al.   Autophagy

Central roles of apoptotic proteins in mitochondrial function

(2012) S M Kilbride et al.   ONCOGENE

Staurosporine Induces Necroptotic Cell Death under Caspase-Compromised Conditions in U937 Cells

(2012) Zsuzsanna A. Dunai et al.   PLoS One

Staurosporine induces megakaryocytic differentiation through the upregulation of JAK/Stat3 signaling pathway

(2011) Hsuan-Yu Peng et al.   ANNALS OF HEMATOLOGY

Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3β/Tyr216, resulting in glycogen synthase kinase 3β activation in SH-SY5Y human neuroblastoma cell lines

(2011) Anastasia Noël et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases

(2010) B Li et al.   CELL DEATH AND DIFFERENTIATION

The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology

(2010) Alberto M. Martelli et al.   Cancers

Glycogen Synthase Kinase-3 and Omi/HtrA2 Induce Annexin A2 Cleavage followed by Cell Cycle Inhibition and Apoptosis

(2009) Chi-Yun Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION