Article
Pharmacology & Pharmacy
Yueqi Wang, Changjian Li, Xiaojie Zhang, Xiaoxuan Kang, Yaru Li, Wenyu Zhang, Yan Chen, Yang Liu, Weigang Wang, Maofa Ge, Libo Du
Summary: The study investigated the impact and mechanisms of PM2.5 exposure on PD symptoms using in vitro and in vivo models, revealing that PM2.5 aggravates behavioral abnormalities in PD by increasing oxidative stress, reducing autophagy and mitophagy levels, and inducing mitochondria-mediated neuronal apoptosis.
Article
Biochemistry & Molecular Biology
Ramesh Pariyar, Tonking Bastola, Dae Ho Lee, Jungwon Seo
Summary: The anti-diabetic drug vildagliptin has been found to have protective effects against motor dysfunction caused by Parkinson's disease (PD), potentially through the regulation of PI3k/Akt, ERK, and JNK signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Britney N. Lizama, Charleen T. Chu
Summary: Autophagy is crucial for cells to remove damaged components and is increasingly studied for its role in various diseases. Research on autophagy and mitochondrial quality control is expanding, particularly in relation to conditions like cancer, immune diseases, and neurodegenerative diseases.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nafisa R. Komilova, Plamena R. Angelova, Alexey Berezhnov, Olga A. Stelmashchuk, Ulugbek Z. Mirkhodjaev, Henry Houlden, Alexander Gourine, Noemi Esteras, Andrey Y. Abramov
Summary: The study shows that acidification of the cytosol through compounds like lactate and pyruvate induces activation of mitophagy and autophagy in cells with PD mutations, protecting against cell death. Moreover, applying lactate to brain slices of WT and Pink1 KO mice also leads to a reduction in pH and increased mitophagy levels. This suggests that compounds which induce cytosolic acidification play a key role in activating protective mechanisms against neurodegeneration in PD.
Article
Biochemistry & Molecular Biology
Changlin Lian, Qiongzhen Huang, Xiangyang Zhong, Zhenyan He, Boyang Liu, Huijun Zeng, Ningbo Xu, Zhao Yang, Chenxin Liao, Zhao Fu, Hongbo Guo
Summary: The study found that adipose-derived stem cells can protect dopaminergic neurons from apoptosis and degeneration, showing therapeutic potential in Parkinson's disease models. The importance of Pentraxin 3 (PTX3) was confirmed in both in vivo and in vitro models, and human recombinant PTX3 (rhPTX3) treatment showed significant effects in Parkinson's disease mice.
Review
Biochemistry & Molecular Biology
Marcello Serra, Annalisa Pinna, Giulia Costa, Alessandro Usiello, Massimo Pasqualetti, Luigi Avallone, Micaela Morelli, Francesco Napolitano
Summary: Rhes is a gene regulated by thyroid hormones that modulates dopamine neurotransmission through inhibition of the striatal cAMP/PKA pathway. It is expressed at high levels in the dorsal striatum and is involved in the survival of midbrain dopaminergic neurons, pointing towards a modulation of autophagy and mitophagy processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ifat Alsharif, Loubna Boukhzar, Benjamin Lefranc, David Godefroy, Juliette Aury-Landas, Jean-Luc do Rego, Jean-Claude do Rego, Frederic Naudet, Arnaud Arabo, Abdeslam Chagraoui, David Maltete, Abdelhamid Benazzouz, Catherine Bauge, Jerome Leprince, Abdel G. Elkahloun, Lee E. Eiden, Youssef Anouar
Summary: PSELT, derived from SELENOT, shows promise as a therapeutic candidate for Parkinson's disease by targeting oxidative stress at multiple intracellular levels.
Article
Biochemistry & Molecular Biology
Jia Liu, Jingjing Jiang, Jingru Qiu, Liyan Wang, Jing Zhuo, Baozhu Wang, Deqing Sun, Shuyan Yu, Haiyan Lou
Summary: UA, a gut metabolite produced from ellagic acid-containing foods, shows potential protective effects against PD by promoting mitochondrial biogenesis and preventing neurotoxicity induced by 6-OHDA. This study provides new insights into the role of UA in regulating mitochondrial dysfunction in PD and suggests potential therapeutic applications.
Article
Cell Biology
Yong-Woo Jun, Soojin Lee, Byung-Kwan Ban, Jin-A Lee, Fen-Biao Gao
Summary: Partial knockdown of MYH10 rescues neurodegeneration in both Drosophila and human iPSC-derived cortical neurons expressing mutant CHMP2B, and MYH10 interacts with ESCRT-III to regulate phagophore closure during mitophagy, revealing novel roles of MYH10 in the autophagy pathway and in ESCRT-related FTD pathogenesis.
Article
Immunology
Yue Qin, Jingru Qiu, Ping Wang, Jia Liu, Yong Zhao, Fan Jiang, Haiyan Lou
Summary: The study found that impaired microglial autophagy exacerbates neuroinflammation and dopaminergic neurodegeneration by modulating NLRP3 inflammasome responses. Enhancing microglial autophagy may be a promising new therapeutic strategy for PD.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Livia Interdonato, Ylenia Marino, Rosalia Crupi, Enrico Gugliandolo, Francesco Macri, Davide Di Paola, Alessio Filippo Peritore, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study evaluated the modulation of autophagy, oxidative stress, and apoptosis with Acai Berries in a rat model of endometriosis. The results showed that Acai Berry inhibited the phosphorylation of PI3K, AKT, and ERK1/2, promoting autophagy, and exerted regulatory effects on cell apoptosis and oxidative stress.
Article
Plant Sciences
Qiang-Ming Li, Xiang Li, Shuang-Qiao Su, Yu-Tong Wang, Tong Xu, Xue-Qiang Zha, Li-Hua Pan, Zhen-Zi Shang, Feng-Yun Zhang, Jian-Ping Luo
Summary: Dendrobine has an antiparkinsonian effect by facilitating MANF-mediated ER stress suppression, reducing motor impairments and dopaminergic neuron apoptosis in a PD mouse model.
Article
Biochemistry & Molecular Biology
Ruru Jia, Yanling Liu, Ke Shuai, Cheng Zhou, Lei Chen, Li Zhu, Xiao-Mei Wu
Summary: The pathogenesis of Parkinson's disease (PD) is complex and requires further exploration. Leucine-rich repeat kinase 2 (LRRK2) is associated with both familial and sporadic PD. Abnormal iron accumulation is found in the substantia nigra of PD patients, but its exact effects are not clear. This study shows that iron dextran exacerbates neurological deficits and loss of dopaminergic neurons in rats with 6-OHDA lesions, and iron promotes the activation of LRRK2, which in turn accelerates ferrous iron uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Huiping Qi, Dongfang Shen, Chenggong Jiang, Huan Wang, Mingxiu Chang
Summary: Neuroprotection targeting mitochondrial dysfunction with ursodeoxycholic acid (UDCA) shows potential therapeutic effects for Parkinson's disease (PD). UDCA improves motor dysfunction, protects dopaminergic neurons, and regulates autophagy and apoptosis through activating the AMPK/mTOR and PINK1/Parkin pathways. The study suggests that UDCA may have pharmacological benefits in treating PD by modulating mitochondrial function.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)