Cell biology in China: Focusing on the lysosome

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Metformin Activates AMPK through the Lysosomal Pathway

(2016) Chen-Song Zhang et al.   Cell Metabolism

Programmed cell death and clearance of cell corpses in Caenorhabditis elegans

(2016) Xiaochen Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Kinesin 1 Drives Autolysosome Tubulation

(2016) Wanqing Du et al.   DEVELOPMENTAL CELL

Intracellular TRPA1 mediates Ca 2+ release from lysosomes in dorsal root ganglion neurons

(2016) Shujiang Shang et al.   JOURNAL OF CELL BIOLOGY

Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion

(2016) Kai Liu et al.   JOURNAL OF CELL BIOLOGY

The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity

(2016) Yuan Li et al.   JOURNAL OF CELL BIOLOGY

Turn up the lysosome

(2016) Paul Saftig et al.   NATURE CELL BIOLOGY

Protein kinase C controls lysosome biogenesis independently of mTORC1

(2016) Yang Li et al.   NATURE CELL BIOLOGY

BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development

(2016) Wenwen Zhou et al.   eLife

Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

(2015) Bei-Bei Chu et al.   CELL

PtdIns(4,5)P2and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance

(2015) Shiya Cheng et al.   JOURNAL OF CELL BIOLOGY

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

(2015) Jennifer Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Lysosomal membrane permeabilization in cell death: Concepts and challenges

(2014) Urška Repnik et al.   MITOCHONDRION

The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans

(2014) Meng Xu et al.   MOLECULAR BIOLOGY OF THE CELL

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin

(2014) Qianqian Chen et al.   Protein & Cell

Aggrephagy: lessons fromC. elegans

(2013) Qun Lu et al.   BIOCHEMICAL JOURNAL

You are what you eat: multifaceted functions of autophagy during C. elegans development

(2013) Peiguo Yang et al.   CELL RESEARCH

The key role of growth hormone–insulin–IGF-1 signaling in aging and cancer

(2013) Vladimir N. Anisimov et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans

(2013) Peipei Zhang et al.   EMBO REPORTS

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy

(2013) Santosh Chauhan et al.   MOLECULAR CELL

Lysosomal integral membrane protein-2: A new player in lysosome-related pathology

(2013) Ashley Gonzalez et al.   MOLECULAR GENETICS AND METABOLISM

Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

(2013) Dante Neculai et al.   NATURE

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Cleaning up the mess: cell corpse clearance in Caenorhabditis elegans

(2012) Sérgio Morgado Pinto et al.   CURRENT OPINION IN CELL BIOLOGY

Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance

(2012) J. Huang et al.   DEVELOPMENT

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Lysosomal pathways to cell death and their therapeutic applications

(2012) Maruša Hafner Česen et al.   EXPERIMENTAL CELL RESEARCH

Apoptotic regulators promote cytokinetic midbody degradation inC. elegans

(2012) Yongping Chai et al.   JOURNAL OF CELL BIOLOGY

Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis

(2012) Kai Zhao et al.   JOURNAL OF LIPID RESEARCH

Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

(2012) Derrick Gibbings et al.   NATURE CELL BIOLOGY

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation

(2012) Yueguang Rong et al.   NATURE CELL BIOLOGY

Cancer-associated lysosomal changes: friends or foes?

(2012) T Kallunki et al.   ONCOGENE

Degradation of the antiviral component ARGONAUTE1 by the autophagy pathway

(2012) B. Derrien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis

(2012) B. Liu et al.   SCIENCE

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans

(2011) Qinghua Zhou et al.   CELL RESEARCH

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

Lysosomal membrane proteins: life between acid and neutral conditions: Figure 1

(2010) Paul Saftig et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Combating apoptosis and multidrug resistant cancers by targeting lysosomes

(2010) Line Groth-Pedersen et al.   CANCER LETTERS

C. elegans Screen Identifies Autophagy Genes Specific to Multicellular Organisms

(2010) Ye Tian et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

(2010) Kai Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation

(2010) P. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance

(2010) Samantha J. Orenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans

(2009) Yuxia Zhang et al.   CELL

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2

(2008) N. Fehrenbacher et al.   CANCER RESEARCH

C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells

(2008) Q. Lu et al.   DEVELOPMENT

Chymotrypsin B Cached in Rat Liver Lysosomes and Involved in Apoptotic Regulation through a Mitochondrial Pathway

(2008) Qi Miao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The small GTPase Rab2 functions in the removal of apoptotic cells inCaenorhabditis elegans

(2008) Paolo M. Mangahas et al.   JOURNAL OF CELL BIOLOGY

Lysosome Biogenesis Mediated by vps-18 Affects Apoptotic Cell Degradation in Caenorhabditis elegans

(2008) Hui Xiao et al.   MOLECULAR BIOLOGY OF THE CELL

A pathway for phagosome maturation during engulfment of apoptotic cells

(2008) Jason M. Kinchen et al.   NATURE CELL BIOLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Phagocytic Receptor CED-1 Initiates a Signaling Pathway for Degrading Engulfed Apoptotic Cells

(2008) Xiaomeng Yu et al.   PLOS BIOLOGY