CDK5-dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons

Cytoplasmic Dynein Transports Axonal Microtubules in a Polarity-Sorting Manner

(2017) Anand N. Rao et al.   Cell Reports

The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1

(2016) Alison E. Twelvetrees et al.   NEURON

Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment

(2016) Marijn Kuijpers et al.   NEURON

Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon

(2016) Xiaoli Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin I and p35 determine the subcellular distribution of Cdk5

(2015) Henning Hagmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Centrosome nucleates numerous ephemeral microtubules and only few of them participate in the radial array

(2015) Irina B. Alieva et al.   CELL BIOLOGY INTERNATIONAL

Control of the Initiation and Termination of Kinesin-1-Driven Transport by Myosin-Ic and Nonmuscle Tropomyosin

(2015) Betsy B. McIntosh et al.   CURRENT BIOLOGY

Dendrite arborization requires the dynein cofactor NudE

(2015) A. L. Arthur et al.   JOURNAL OF CELL SCIENCE

Control of microtubule organization and dynamics: two ends in the limelight

(2015) Anna Akhmanova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays

(2015) Sam F.B. van Beuningen et al.   NEURON

Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons

(2015) Miguel Veas-Pérez de Tudela et al.   Scientific Reports

Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein

(2015) Eva Klinman et al.   Cell Reports

Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone

(2015) Ginny G. Farías et al.   Cell Reports

STED Nanoscopy Reveals the Ubiquity of Subcortical Cytoskeleton Periodicity in Living Neurons

(2015) Elisa D’Este et al.   Cell Reports

The axonal cytoskeleton: from organization to function

(2015) Josta T. Kevenaar et al.   Frontiers in Molecular Neuroscience

Nucleation and Dynamics of Golgi-derived Microtubules

(2015) Anna A. W. M. Sanders et al.   Frontiers in Neuroscience

Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases

(2015) Joanna Lipka et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

GM130 Is Required for Compartmental Organization of Dendritic Golgi Outposts

(2014) Wei Zhou et al.   CURRENT BIOLOGY

Axon and dendritic trafficking

(2014) Celine I Maeder et al.   CURRENT OPINION IN NEUROBIOLOGY

The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches

(2014) Rajiv Sainath et al.   Developmental Neurobiology

Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments

(2014) Steven L. Jones et al.   JOURNAL OF CELL BIOLOGY

Selective Microtubule-Based Transport of Dendritic Membrane Proteins Arises in Concert with Axon Specification

(2014) J. D. Petersen et al.   JOURNAL OF NEUROSCIENCE

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Selective filtering defect at the axon initial segment in Alzheimer’s disease mouse models

(2014) Xiaqin Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

(2014) Katerina Toropova et al.   eLife

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

(2013) A. J. Moughamian et al.   JOURNAL OF NEUROSCIENCE

Lis1 Acts as a “Clutch” between the ATPase and Microtubule-Binding Domains of the Dynein Motor

(2012) Julie Huang et al.   CELL

Lis1 is an initiation factor for dynein-driven organelle transport

(2012) Martin J. Egan et al.   JOURNAL OF CELL BIOLOGY

Cyclin-Dependent Kinase 5 Regulates the Polarized Trafficking of Neuropeptide-Containing Dense-Core Vesicles in Caenorhabditis elegans Motor Neurons

(2012) P. R. Goodwin et al.   JOURNAL OF NEUROSCIENCE

Cyclin-dependent kinase 5 is required for normal cerebellar development

(2012) A. Kumazawa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Golgi Outposts Shape Dendrite Morphology by Functioning as Sites of Acentrosomal Microtubule Nucleation in Neurons

(2012) Kassandra M. Ori-McKenney et al.   NEURON

Actin, Spectrin, and Associated Proteins Form a Periodic Cytoskeletal Structure in Axons

(2012) K. Xu et al.   SCIENCE

Networks of Polarized Actin Filaments in the Axon Initial Segment Provide a Mechanism for Sorting Axonal and Dendritic Proteins

(2012) Kaori Watanabe et al.   Cell Reports

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

The axon initial segment in nervous system disease and injury

(2011) Shelly A. Buffington et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein

(2011) Eliza Żyłkiewicz et al.   JOURNAL OF CELL BIOLOGY

High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport

(2011) Julie Y. Yi et al.   JOURNAL OF CELL BIOLOGY

Cdk5 Regulates the Size of an Axon Initial Segment-Like Compartment in Mushroom Body Neurons of the Drosophila Central Brain

(2011) S. Trunova et al.   JOURNAL OF NEUROSCIENCE

A Cdk5-Dependent Switch Regulates Lis1/Ndel1/Dynein-Driven Organelle Transport in Adult Axons

(2011) J. P. Pandey et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of polarized membrane trafficking in neurons — Focusing in on endosomes

(2011) Zofia M. Lasiecka et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Two Cyclin-Dependent Kinase Pathways Are Essential for Polarized Trafficking of Presynaptic Components

(2010) Chan-Yen Ou et al.   CELL

Building and maintaining the axon initial segment

(2010) Matthew S Grubb et al.   CURRENT OPINION IN NEUROBIOLOGY

The axon initial segment and the maintenance of neuronal polarity

(2010) Matthew N. Rasband   NATURE REVIEWS NEUROSCIENCE

A Selective Filter for Cytoplasmic Transport at the Axon Initial Segment

(2009) Ai-hong Song et al.   CELL

Specificity of Cytoplasmic Dynein Subunits in Discrete Membrane-trafficking Steps

(2009) Krysten J. Palmer et al.   MOLECULAR BIOLOGY OF THE CELL

Nudel Promotes Axonal Lysosome Clearance and Endo-lysosome Formation via Dynein-Mediated Transport

(2009) Qiangge Zhang et al.   TRAFFIC

An Unusual Member of the Cdk Family: Cdk5

(2008) Fatema A. Dhariwala et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

(2008) Carolina Maestre et al.   EMBO JOURNAL

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity

(2008) Kristian L. Hedstrom et al.   JOURNAL OF CELL BIOLOGY

Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells

(2008) Sachin Hebbar et al.   JOURNAL OF CELL BIOLOGY

Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons

(2008) Yi Zheng et al.   NATURE CELL BIOLOGY

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE