Systems Approaches Evaluating the Perturbation of Xenobiotic Metabolism in Response to Cigarette Smoke Exposure in Nasal and Bronchial Tissues

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers

(2013) Carole Mathis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Case study: the role of mechanistic network models in systems toxicology

(2013) Julia Hoeng et al.   DRUG DISCOVERY TODAY

Quantitative assessment of biological impact using transcriptomic data and mechanistic network models

(2013) Ty M. Thomson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

(2012) Florian Martin et al.   BMC Systems Biology

Molecular Signature of Smoking in Human Lung Tissues

(2012) Y. Bosse et al.   CANCER RESEARCH

Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals

(2012) Amit Sharma et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Nicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Binding and Access Channel in Human Cytochrome P450 2A6 and 2A13 Enzymes

(2012) Natasha M. DeVore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cigarette Smoke Promotes Drug Resistance and Expansion of Cancer Stem Cell-Like Side Population

(2012) Yi An et al.   PLoS One

Diagnostic flexible bronchoscopy and accessory techniques

(2012) J. Dionísio   Revista Portuguesa de Pneumologia

Construction of a computable cell proliferation network focused on non-diseased lung cells

(2011) Jurjen W Westra et al.   BMC Systems Biology

A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue

(2011) Walter K Schlage et al.   BMC Systems Biology

Smoking-related O4-ethylthymidine formation in human lung tissue and comparisons with bulky DNA adducts

(2011) L. Anna et al.   MUTAGENESIS

Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Nuclear Translocator Expression in Human and Rat Placentas and Transcription Activity in Human Trophoblast Cultures

(2011) Lucie Stejskalova et al.   TOXICOLOGICAL SCIENCES

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

(2010) Alejandro A. Pezzulo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Threshold of Biologic Responses of the Small Airway Epithelium to Low Levels of Tobacco Smoke

(2010) Yael Strulovici-Barel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of Cigarette Smoke on the Human Oral Mucosal Transcriptome

(2010) J. O. Boyle et al.   Cancer Prevention Research

Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s

(2010) Viola Tamási et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung

(2010) J. L. McQualter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xenobiotic Metabolism, Disposition, and Regulation by Receptors: From Biochemical Phenomenon to Predictors of Major Toxicities

(2010) C. J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium

(2009) Xiaoling Zhang et al.   PHYSIOLOGICAL GENOMICS

MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium

(2009) F. Schembri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smoking-induced gene expression changes in the bronchial airway are reflected in nasal and buccal epithelium

(2008) Sriram Sridhar et al.   BMC GENOMICS

The Field of Tissue Injury in the Lung and Airway

(2008) K. Steiling et al.   Cancer Prevention Research

The Oral Cavity as a Molecular Mirror of Lung Carcinogenesis

(2008) David Sidransky   Cancer Prevention Research